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- Mannose_6-phosphate abstract "Mannose-6-phosphate (M6P) is a molecule bound by lectin in the immune system. M6P is converted to fructose 6-phosphate by mannose phosphate isomerase.M6P is a key targeting signal for acid hydrolase precursor proteins that are destined for transport to lysosomes. The M6P tag is added to such proteins in the cis-Golgi apparatus. Specifically, in a reaction involving uridine diphosphate (UDP) and N-acetylglucosamine, the enzyme N-acetylglucosamine-1-phosphate transferase catalyzes the N-linked glycosylation of asparagine residues with M6P. Once appropriately marked with the M6P targeting signal, these proteins are moved to the trans-Golgi network. There, the M6P moiety is recognized and bound by mannose 6-phosphate receptor (MPR) proteins at pH 6.5-6.7.The M6P-tagged lysosomal enzymes are shipped to the late endosomes via vesicular transport. Enzyme replacement therapy (ERT) for several lysosomal storage diseases relies on this pathway to efficiently direct synthetic enzymes to the lysosome where each can metabolize its particular substrate. The pH in the late endosome can reach 6.0, which causes dissociation of M6P from its receptor. Upon release, the enzymes are ferried to their final destination in the lysosomes. The MPRs are packed into vesicles that bud off the late endosome and return to the "trans"-Golgi network. In this way, the MPRs can be recycled.".
- Mannose_6-phosphate thumbnail Mannose-6-phosphate.svg?width=300.
- Mannose_6-phosphate wikiPageExternalLink movie-flash.htm.
- Mannose_6-phosphate wikiPageID "10971813".
- Mannose_6-phosphate wikiPageLength "3965".
- Mannose_6-phosphate wikiPageOutDegree "24".
- Mannose_6-phosphate wikiPageRevisionID "678958671".
- Mannose_6-phosphate wikiPageWikiLink Acid_hydrolase.
- Mannose_6-phosphate wikiPageWikiLink Asparagine.
- Mannose_6-phosphate wikiPageWikiLink Category:Monosaccharide_derivatives.
- Mannose_6-phosphate wikiPageWikiLink Category:Organophosphates.
- Mannose_6-phosphate wikiPageWikiLink Endosome.
- Mannose_6-phosphate wikiPageWikiLink Endosomes.
- Mannose_6-phosphate wikiPageWikiLink Enzyme_replacement_therapy.
- Mannose_6-phosphate wikiPageWikiLink Fructose_6-phosphate.
- Mannose_6-phosphate wikiPageWikiLink Glycosylation.
- Mannose_6-phosphate wikiPageWikiLink Golgi_apparatus.
- Mannose_6-phosphate wikiPageWikiLink I-cell_disease.
- Mannose_6-phosphate wikiPageWikiLink Immune_system.
- Mannose_6-phosphate wikiPageWikiLink Insulin-like_growth_factor_2_receptor.
- Mannose_6-phosphate wikiPageWikiLink Lectin.
- Mannose_6-phosphate wikiPageWikiLink Lysosomal_storage_disease.
- Mannose_6-phosphate wikiPageWikiLink Lysosomal_storage_diseases.
- Mannose_6-phosphate wikiPageWikiLink Lysosome.
- Mannose_6-phosphate wikiPageWikiLink Mannose.
- Mannose_6-phosphate wikiPageWikiLink Mannose_1-phosphate.
- Mannose_6-phosphate wikiPageWikiLink Mannose_6-phosphate_receptor.
- Mannose_6-phosphate wikiPageWikiLink Mannose_phosphate_isomerase.
- Mannose_6-phosphate wikiPageWikiLink Moiety_(chemistry).
- Mannose_6-phosphate wikiPageWikiLink N-Acetylglucosamine.
- Mannose_6-phosphate wikiPageWikiLink N-acetylglucosamine.
- Mannose_6-phosphate wikiPageWikiLink N-acetylglucosamine-1-phosphate_transferase.
- Mannose_6-phosphate wikiPageWikiLink Protein_precursor.
- Mannose_6-phosphate wikiPageWikiLink Uridine_diphosphate.
- Mannose_6-phosphate wikiPageWikiLinkText "Man-6-phosphate".
- Mannose_6-phosphate wikiPageWikiLinkText "Mannose 6-phosphate".
- Mannose_6-phosphate wikiPageWikiLinkText "mannose 6-phosphate".
- Mannose_6-phosphate hasPhotoCollection Mannose_6-phosphate.
- Mannose_6-phosphate imagefile "Mannose-6-phosphate.svg".
- Mannose_6-phosphate verifiedrevid "450950432".
- Mannose_6-phosphate watchedfields "changed".
- Mannose_6-phosphate wikiPageUsesTemplate Template:Biochem-stub.
- Mannose_6-phosphate wikiPageUsesTemplate Template:Chembox.
- Mannose_6-phosphate wikiPageUsesTemplate Template:Fructose_and_galactose_metabolic_intermediates.
- Mannose_6-phosphate wikiPageUsesTemplate Template:MeshName.
- Mannose_6-phosphate subject Category:Monosaccharide_derivatives.
- Mannose_6-phosphate subject Category:Organophosphates.
- Mannose_6-phosphate hypernym Molecule.
- Mannose_6-phosphate type ChemicalCompound.
- Mannose_6-phosphate type ChemicalSubstance.
- Mannose_6-phosphate type Ester.
- Mannose_6-phosphate type Monosaccharide.
- Mannose_6-phosphate type Organophosphate.
- Mannose_6-phosphate type Organophosphoru.
- Mannose_6-phosphate type Organophosphate.
- Mannose_6-phosphate type Organophosphoru.
- Mannose_6-phosphate type ChemicalObject.
- Mannose_6-phosphate type Thing.
- Mannose_6-phosphate type Q11173.
- Mannose_6-phosphate comment "Mannose-6-phosphate (M6P) is a molecule bound by lectin in the immune system. M6P is converted to fructose 6-phosphate by mannose phosphate isomerase.M6P is a key targeting signal for acid hydrolase precursor proteins that are destined for transport to lysosomes. The M6P tag is added to such proteins in the cis-Golgi apparatus.".
- Mannose_6-phosphate label "Mannose 6-phosphate".
- Mannose_6-phosphate sameAs Manosa-6-fosfat.
- Mannose_6-phosphate sameAs Manóza-6-fosfát.
- Mannose_6-phosphate sameAs Mannose-6-phosphat.
- Mannose_6-phosphate sameAs Manosa-6-fosfato.
- Mannose_6-phosphate sameAs مانوز_۶-فسفات.
- Mannose_6-phosphate sameAs Mannoosi-6-fosfaatti.
- Mannose_6-phosphate sameAs Mannose-6-phosphate.
- Mannose_6-phosphate sameAs Manosa_6-fosfato.
- Mannose_6-phosphate sameAs m.02kdb5f.
- Mannose_6-phosphate sameAs Manoza-6-fosfat.
- Mannose_6-phosphate sameAs Manoza-6-fosfat.
- Mannose_6-phosphate sameAs Q259546.
- Mannose_6-phosphate sameAs Q259546.
- Mannose_6-phosphate sameAs 甘露糖-6-磷酸.
- Mannose_6-phosphate wasDerivedFrom Mannose_6-phosphate?oldid=678958671.
- Mannose_6-phosphate depiction Mannose-6-phosphate.svg.
- Mannose_6-phosphate isPrimaryTopicOf Mannose_6-phosphate.