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- Mangafodipir abstract "Mangafodipir (sold under the brand name Teslascan as mangafodipir trisodium) is a contrast agent delivered intravenously to enhance contrast in magnetic resonance imaging (MRI) of the liver. It has two parts, paramagnetic manganese (II) ions and the chelating agent fodipir (dipyridoxyl diphosphate, DPDP). Normal liver tissue absorbs the manganese more than abnormal or cancerous tissue. The manganese shortens the longitudinal relaxation time (T1), making the normal tissue appear brighter in MRIs. This enhanced contrast allows lesions to be more easily identified.Teslascan was withdrawn from the US market in 2003 and the European market in 2012.Reactive oxygen species (ROS) and reactive nitrogen species (RNS) participate in pathological tissue damage. Mitochondrial manganese superoxide dismutase (MnSOD) normally keeps ROS and RNS in check. During development of mangafodipir as an MRI contrast agent, it was discovered that it possessed MnSOD mimetic activity. Mangafodipir has been tested as a chemotherapy adjunct in cancer patients and as an adjunct to percutaneous coronary intervention in patients with myocardial infarctions, with promising results. Whereas MRI contrast depends on release of Mn2+, the MnSOD mimetic activity depends on Mn2+ that remains bound to DPDP. Calmangafodipir [Ca4Mn(DPDP)5] (brand name PledOx) is stabilized with respect to Mn2+ and has improved therapeutic activity. Calmangafodipir is being explored as a chemotherapy adjunct in cancer patients.".
- Mangafodipir atcPrefix "V08".
- Mangafodipir atcSuffix "CA05".
- Mangafodipir casNumber "119797-12-5".
- Mangafodipir fdaUniiCode "N02W67RKJS".
- Mangafodipir pubchem "3086672".
- Mangafodipir thumbnail Mangafodipir_3D_sticks.png?width=300.
- Mangafodipir wikiPageExternalLink Teslascaninj.htm.
- Mangafodipir wikiPageExternalLink 203456.html.
- Mangafodipir wikiPageExternalLink www.teslascan.com.
- Mangafodipir wikiPageID "5438189".
- Mangafodipir wikiPageLength "5164".
- Mangafodipir wikiPageOutDegree "10".
- Mangafodipir wikiPageRevisionID "679843814".
- Mangafodipir wikiPageWikiLink Category:MRI_contrast_agents.
- Mangafodipir wikiPageWikiLink Category:Manganese_compounds.
- Mangafodipir wikiPageWikiLink Chelation.
- Mangafodipir wikiPageWikiLink Contrast_agent.
- Mangafodipir wikiPageWikiLink Contrast_medium.
- Mangafodipir wikiPageWikiLink Intravenous.
- Mangafodipir wikiPageWikiLink Intravenous_therapy.
- Mangafodipir wikiPageWikiLink Kidney.
- Mangafodipir wikiPageWikiLink Magnetic_resonance_imaging.
- Mangafodipir wikiPageWikiLink Paramagnetism.
- Mangafodipir wikiPageWikiLink Relaxation_(NMR).
- Mangafodipir wikiPageWikiLinkText "Mangafodipir".
- Mangafodipir wikiPageWikiLinkText "mangafodipir".
- Mangafodipir atcPrefix "V08".
- Mangafodipir atcSuffix "CA05".
- Mangafodipir bioavailability "NA".
- Mangafodipir c "22".
- Mangafodipir casNumber "119797".
- Mangafodipir chembl "1628235".
- Mangafodipir chemspiderid "2343239".
- Mangafodipir eliminationHalfLife "1200.0".
- Mangafodipir eliminationHalfLife "3000.0".
- Mangafodipir excretion "Renal and fecal".
- Mangafodipir excretion "Renal".
- Mangafodipir h "28".
- Mangafodipir hasPhotoCollection Mangafodipir.
- Mangafodipir image "mangafodipir.png".
- Mangafodipir inchi "1".
- Mangafodipir inchikey "QDQFSBKXQQZVTB-UHFFFAOYAF".
- Mangafodipir mn "1".
- Mangafodipir molecularWeight "689.362".
- Mangafodipir n "4".
- Mangafodipir o "14".
- Mangafodipir p "2".
- Mangafodipir pregnancyCategory "Not to be used".
- Mangafodipir proteinBound "27.0".
- Mangafodipir proteinBound "Negligible".
- Mangafodipir pubchem "3086672".
- Mangafodipir routesOfAdministration Intravenous_therapy.
- Mangafodipir smiles "[Mn+2].O=POCc1cncC".
- Mangafodipir stdinchi "1".
- Mangafodipir stdinchikey "QDQFSBKXQQZVTB-UHFFFAOYSA-N".
- Mangafodipir unii "N02W67RKJS".
- Mangafodipir verifiedfields "changed".
- Mangafodipir verifiedrevid "462099595".
- Mangafodipir wikiPageUsesTemplate Template:Contrast_media.
- Mangafodipir wikiPageUsesTemplate Template:Drug-stub.
- Mangafodipir wikiPageUsesTemplate Template:Drugbox.
- Mangafodipir wikiPageUsesTemplate Template:Reflist.
- Mangafodipir subject Category:MRI_contrast_agents.
- Mangafodipir subject Category:Manganese_compounds.
- Mangafodipir hypernym Agent.
- Mangafodipir type Agent.
- Mangafodipir type ChemicalSubstance.
- Mangafodipir type Drug.
- Mangafodipir type Agent.
- Mangafodipir type Chemical.
- Mangafodipir type ChemicalObject.
- Mangafodipir type Thing.
- Mangafodipir type Q8386.
- Mangafodipir comment "Mangafodipir (sold under the brand name Teslascan as mangafodipir trisodium) is a contrast agent delivered intravenously to enhance contrast in magnetic resonance imaging (MRI) of the liver. It has two parts, paramagnetic manganese (II) ions and the chelating agent fodipir (dipyridoxyl diphosphate, DPDP). Normal liver tissue absorbs the manganese more than abnormal or cancerous tissue.".
- Mangafodipir label "Mangafodipir".
- Mangafodipir sameAs Mangafodipir.
- Mangafodipir sameAs m.0dlxb8.
- Mangafodipir sameAs Мангафодипир.
- Mangafodipir sameAs Mangafodipir.
- Mangafodipir sameAs Mangafodipir.
- Mangafodipir sameAs Q423624.
- Mangafodipir sameAs Q423624.
- Mangafodipir wasDerivedFrom Mangafodipir?oldid=679843814.
- Mangafodipir depiction Mangafodipir_3D_sticks.png.
- Mangafodipir isPrimaryTopicOf Mangafodipir.