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- MamL-1_domain abstract "In molecular biology there are a number of neurogenic proteins referred to as mastermind-like proteins (MAMLs) of which this domain is the N-terminal region. Mastermind-like proteins act as critical transcriptional co-activators for Notch signaling.The N-terminal domain of MAML proteins, MAML1, MAML2, MAML3, is a polypeptide of up to 70 residues, numbers 15-67 of which adopt an elongated kinked helix that wraps around ANK and CSL forming one of the complexes in the build-up of the Notch transcriptional complex for recruiting general transcription factors. This N-terminal domain is responsible for its interaction with the ankyrin repeat region of the Notch proteins NOTCH1, NOTCH2, NOTCH3 and NOTCH4. It forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1, and also binds CREBBP/CBP and CDK8. The C-terminal region is required for transcriptional activation.Notch receptors are cleaved upon ligand engagement and the intracellular domain of Notch shuttles to the nucleus. MAMLs form a functional DNA-binding complex with the cleaved Notch receptor and the transcription factor CSL, thereby regulating transcriptional events that are specific to the Notch pathway. MAML proteins may also play roles as key transcriptional co-activators in other signal transduction pathways as well, including: muscle differentiation and myopathies (MEF2C), tumour suppressor pathway (p53) and colon carcinoma survival (beta-catenin). MAML proteins could mediate cross-talk among the various signaling pathways and the diverse activities of the MAML proteins converge to impact normal biological processes and human diseases, including cancers.".
- MamL-1_domain symbol "MamL-1".
- MamL-1_domain wikiPageID "32115582".
- MamL-1_domain wikiPageLength "7185".
- MamL-1_domain wikiPageOutDegree "36".
- MamL-1_domain wikiPageRevisionID "592349263".
- MamL-1_domain wikiPageWikiLink Ankyrin_repeat.
- MamL-1_domain wikiPageWikiLink Apoptosis.
- MamL-1_domain wikiPageWikiLink Biology.
- MamL-1_domain wikiPageWikiLink Cancer.
- MamL-1_domain wikiPageWikiLink Carcinoma.
- MamL-1_domain wikiPageWikiLink Category:Protein_domains.
- MamL-1_domain wikiPageWikiLink Cell_nucleus.
- MamL-1_domain wikiPageWikiLink Cellular_differentiation.
- MamL-1_domain wikiPageWikiLink Colon_cancer.
- MamL-1_domain wikiPageWikiLink Colorectal_cancer.
- MamL-1_domain wikiPageWikiLink Complex_(chemistry).
- MamL-1_domain wikiPageWikiLink Coordination_complex.
- MamL-1_domain wikiPageWikiLink Differentiation_(cellular).
- MamL-1_domain wikiPageWikiLink Domain_(biology).
- MamL-1_domain wikiPageWikiLink Helix.
- MamL-1_domain wikiPageWikiLink Homo_sapiens.
- MamL-1_domain wikiPageWikiLink Intracellular.
- MamL-1_domain wikiPageWikiLink Ligand_(biochemistry).
- MamL-1_domain wikiPageWikiLink MAML1.
- MamL-1_domain wikiPageWikiLink MAML2.
- MamL-1_domain wikiPageWikiLink Molecular_binding.
- MamL-1_domain wikiPageWikiLink Multiprotein_complex.
- MamL-1_domain wikiPageWikiLink Muscle.
- MamL-1_domain wikiPageWikiLink Nervous_system.
- MamL-1_domain wikiPageWikiLink Neurogenic.
- MamL-1_domain wikiPageWikiLink Notch_signaling.
- MamL-1_domain wikiPageWikiLink Notch_signaling_pathway.
- MamL-1_domain wikiPageWikiLink Protein.
- MamL-1_domain wikiPageWikiLink Protein_complex.
- MamL-1_domain wikiPageWikiLink Proteins.
- MamL-1_domain wikiPageWikiLink Receptor_(biochemistry).
- MamL-1_domain wikiPageWikiLink Signal_transduction.
- MamL-1_domain wikiPageWikiLink Signal_transduction_pathways.
- MamL-1_domain wikiPageWikiLink Transcription_(genetics).
- MamL-1_domain wikiPageWikiLink Transcription_factor.
- MamL-1_domain wikiPageWikiLink Tumor_suppressor_gene.
- MamL-1_domain wikiPageWikiLinkText "MamL-1 domain".
- MamL-1_domain wikiPageWikiLinkText "MamL-1".
- MamL-1_domain hasPhotoCollection MamL-1_domain.
- MamL-1_domain interpro "IPR019082".
- MamL-1_domain name "MamL-1".
- MamL-1_domain pfam "PF09596".
- MamL-1_domain symbol "MamL-1".
- MamL-1_domain wikiPageUsesTemplate Template:Infobox_protein_family.
- MamL-1_domain wikiPageUsesTemplate Template:InterPro_content.
- MamL-1_domain wikiPageUsesTemplate Template:Reflist.
- MamL-1_domain subject Category:Protein_domains.
- MamL-1_domain hypernym Number.
- MamL-1_domain type Article.
- MamL-1_domain type Biomolecule.
- MamL-1_domain type Protein.
- MamL-1_domain type Article.
- MamL-1_domain type Domain.
- MamL-1_domain type Thing.
- MamL-1_domain type Q206229.
- MamL-1_domain type Q8054.
- MamL-1_domain comment "In molecular biology there are a number of neurogenic proteins referred to as mastermind-like proteins (MAMLs) of which this domain is the N-terminal region.".
- MamL-1_domain label "MamL-1 domain".
- MamL-1_domain sameAs m.0gx052q.
- MamL-1_domain sameAs Q6745223.
- MamL-1_domain sameAs Q6745223.
- MamL-1_domain wasDerivedFrom MamL-1_domain?oldid=592349263.
- MamL-1_domain isPrimaryTopicOf MamL-1_domain.