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- Macitentan abstract "Macitentan (trade name Opsumit) is an endothelin receptor antagonist (ERA) approved for the treatment of pulmonary arterial hypertension (PAH). The other two ERAs marketed as of 2014 are bosentan and ambrisentan. Macitentan is a dual ERA, meaning that it acts as an antagonist of two endothelin (ET) receptor subtypes, ETA and ETB. However, macitentan has a 50-fold increased selectivity for the ETA subtype compared to the ETB subtype. The drug received approval from the U.S. Food and Drug Administration (FDA) on October 13, 2013.".
- Macitentan atcPrefix "C02".
- Macitentan atcSuffix "KX04".
- Macitentan casNumber "441798-33-0".
- Macitentan chEBI "76607".
- Macitentan iupacName "N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide".
- Macitentan pubchem "16004692".
- Macitentan thumbnail Macitentan_skeletal.svg?width=300.
- Macitentan wikiPageExternalLink www.actelion.nl.
- Macitentan wikiPageID "36797118".
- Macitentan wikiPageLength "8002".
- Macitentan wikiPageOutDegree "17".
- Macitentan wikiPageRevisionID "679804750".
- Macitentan wikiPageWikiLink Ambrisentan.
- Macitentan wikiPageWikiLink Area_under_the_curve.
- Macitentan wikiPageWikiLink Bosentan.
- Macitentan wikiPageWikiLink CYP3A4.
- Macitentan wikiPageWikiLink Category:Endothelin_receptor_antagonists.
- Macitentan wikiPageWikiLink Ciclosporin.
- Macitentan wikiPageWikiLink Endothelin.
- Macitentan wikiPageWikiLink Endothelin_receptor_antagonist.
- Macitentan wikiPageWikiLink Endothelin_receptor_type_A.
- Macitentan wikiPageWikiLink Endothelin_receptor_type_B.
- Macitentan wikiPageWikiLink Food_and_Drug_Administration.
- Macitentan wikiPageWikiLink Gq_alpha_subunit.
- Macitentan wikiPageWikiLink Gαq.
- Macitentan wikiPageWikiLink Integral.
- Macitentan wikiPageWikiLink Ketoconazole.
- Macitentan wikiPageWikiLink Pulmonary_arterial_hypertension.
- Macitentan wikiPageWikiLink Pulmonary_hypertension.
- Macitentan wikiPageWikiLink Rifampicin.
- Macitentan wikiPageWikiLink File:ACT-132577_skeletal.svg.
- Macitentan wikiPageWikiLinkText "Macitentan".
- Macitentan wikiPageWikiLinkText "macitentan".
- Macitentan atcPrefix "2.0".
- Macitentan atcSuffix "KX04".
- Macitentan br "2".
- Macitentan c "19".
- Macitentan casNumber "441798".
- Macitentan chebi "76607".
- Macitentan chemspiderid "13134960".
- Macitentan excretion "2".
- Macitentan h "20".
- Macitentan hasPhotoCollection Macitentan.
- Macitentan iupacName "N-[5--6-[2-[oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide".
- Macitentan legalStatus "FDA approved drug".
- Macitentan legalUs "Rx-only".
- Macitentan metabolism "Hydrolysis, oxidation".
- Macitentan molecularWeight "588.273".
- Macitentan n "6".
- Macitentan o "4".
- Macitentan pregnancyUs "X".
- Macitentan pubchem "16004692".
- Macitentan routesOfAdministration "Oral".
- Macitentan s "1".
- Macitentan smiles "Brc1cccc3cNSNCCC".
- Macitentan stdinchi "1".
- Macitentan stdinchikey "JGCMEBMXRHSZKX-UHFFFAOYSA-N".
- Macitentan synonyms "ACT-064992".
- Macitentan tradename "Opsumit".
- Macitentan wikiPageUsesTemplate Template:Clear-left.
- Macitentan wikiPageUsesTemplate Template:Drugbox.
- Macitentan wikiPageUsesTemplate Template:PAH_rx.
- Macitentan wikiPageUsesTemplate Template:Peptidergics.
- Macitentan wikiPageUsesTemplate Template:Reflist.
- Macitentan wikiPageUsesTemplate Template:Technical.
- Macitentan subject Category:Endothelin_receptor_antagonists.
- Macitentan hypernym Antagonist.
- Macitentan type Article.
- Macitentan type ChemicalSubstance.
- Macitentan type Drug.
- Macitentan type Antagonist.
- Macitentan type Article.
- Macitentan type Drug.
- Macitentan type ChemicalObject.
- Macitentan type Thing.
- Macitentan type Q8386.
- Macitentan comment "Macitentan (trade name Opsumit) is an endothelin receptor antagonist (ERA) approved for the treatment of pulmonary arterial hypertension (PAH). The other two ERAs marketed as of 2014 are bosentan and ambrisentan. Macitentan is a dual ERA, meaning that it acts as an antagonist of two endothelin (ET) receptor subtypes, ETA and ETB. However, macitentan has a 50-fold increased selectivity for the ETA subtype compared to the ETB subtype. The drug received approval from the U.S.".
- Macitentan label "Macitentan".
- Macitentan sameAs Macitentan.
- Macitentan sameAs Macitentan.
- Macitentan sameAs マシテンタン.
- Macitentan sameAs Macitentan.
- Macitentan sameAs m.0ll0nkk.
- Macitentan sameAs Macitentan.
- Macitentan sameAs Macitentan.
- Macitentan sameAs Q6724151.
- Macitentan sameAs Q6724151.
- Macitentan wasDerivedFrom Macitentan?oldid=679804750.
- Macitentan depiction Macitentan_skeletal.svg.
- Macitentan isPrimaryTopicOf Macitentan.