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- MTEP abstract "3-((2-Methyl-4-thiazolyl)ethynyl)pyridine (MTEP) is a research drug that was developed by Merck & Co. as a selective allosteric antagonist of the metabotropic glutamate receptor subtype mGluR5. Identified through structure-activity relationship studies on an older mGluR5 antagonist MPEP, MTEP has subsequently itself acted as a lead compound for newer and even more improved drugs.MTEP is both more potent and more selective than MPEP as a mGluR5 antagonist, and produces similar neuroprotective, antidepressant, analgesic, and anxiolytic effects but with either similar or higher efficacy depending on the test used.MTEP also has similar efficacy to MPEP in reducing the symptoms of morphine withdrawal, and has anti-addictive effects in a variety of animal models, both reducing ethanol self-administration, and also decreasing the addictive effects of nicotine, cocaine and methamphetamine.".
- MTEP casNumber "329205-68-7".
- MTEP iupacName "3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine".
- MTEP pubchem "9794218".
- MTEP thumbnail Mtep.png?width=300.
- MTEP wikiPageID "20245287".
- MTEP wikiPageLength "15649".
- MTEP wikiPageOutDegree "24".
- MTEP wikiPageRevisionID "682070965".
- MTEP wikiPageWikiLink 2-Methyl-6-(phenylethynyl)pyridine.
- MTEP wikiPageWikiLink Allosteric.
- MTEP wikiPageWikiLink Allosteric_regulation.
- MTEP wikiPageWikiLink Analgesic.
- MTEP wikiPageWikiLink Antagonist_(pharmacology).
- MTEP wikiPageWikiLink Antidepressant.
- MTEP wikiPageWikiLink Anxiolytic.
- MTEP wikiPageWikiLink Category:Alkynes.
- MTEP wikiPageWikiLink Category:MGlu5_receptor_antagonists.
- MTEP wikiPageWikiLink Category:Pyridines.
- MTEP wikiPageWikiLink Category:Thiazoles.
- MTEP wikiPageWikiLink Cocaine.
- MTEP wikiPageWikiLink Drug_withdrawal.
- MTEP wikiPageWikiLink Efficacy.
- MTEP wikiPageWikiLink Functional_selectivity.
- MTEP wikiPageWikiLink Lead_compound.
- MTEP wikiPageWikiLink Merck_&_Co..
- MTEP wikiPageWikiLink Metabotropic_glutamate_receptor.
- MTEP wikiPageWikiLink Metabotropic_glutamate_receptor_5.
- MTEP wikiPageWikiLink Methamphetamine.
- MTEP wikiPageWikiLink Morphine.
- MTEP wikiPageWikiLink Neuroprotection.
- MTEP wikiPageWikiLink Neuroprotective.
- MTEP wikiPageWikiLink Nicotine.
- MTEP wikiPageWikiLink Potency_(pharmacology).
- MTEP wikiPageWikiLink Receptor_antagonist.
- MTEP wikiPageWikiLink Structure-activity_relationship.
- MTEP wikiPageWikiLink Structure–activity_relationship.
- MTEP wikiPageWikiLinkText "MTEP".
- MTEP alt "Skeletal formula".
- MTEP alt "Space-filling model".
- MTEP c "11".
- MTEP casNumber "329205".
- MTEP chemspiderid "7969985".
- MTEP h "8".
- MTEP hasPhotoCollection MTEP.
- MTEP image "MTEP-3D-spacefill.png".
- MTEP inchi "1".
- MTEP inchikey "NRBNGHCYDWUVLC-UHFFFAOYAD".
- MTEP iupacName "3".
- MTEP iupharLigand "3336".
- MTEP molecularWeight "200.26".
- MTEP n "2".
- MTEP pubchem "9794218".
- MTEP s "1".
- MTEP smiles "CC1=NCC#CC2=CN=CC=C2".
- MTEP stdinchi "1".
- MTEP stdinchikey "NRBNGHCYDWUVLC-UHFFFAOYSA-N".
- MTEP verifiedfields "changed".
- MTEP verifiedrevid "424696647".
- MTEP watchedfields "changed".
- MTEP width "200".
- MTEP wikiPageUsesTemplate Template:Drugbox.
- MTEP wikiPageUsesTemplate Template:Glutamatergics.
- MTEP wikiPageUsesTemplate Template:Reflist.
- MTEP subject Category:Alkynes.
- MTEP subject Category:MGlu5_receptor_antagonists.
- MTEP subject Category:Pyridines.
- MTEP subject Category:Thiazoles.
- MTEP hypernym Drug.
- MTEP type Article.
- MTEP type ChemicalSubstance.
- MTEP type Drug.
- MTEP type Alkyne.
- MTEP type Antagonist.
- MTEP type Article.
- MTEP type Azole.
- MTEP type Chemical.
- MTEP type Drug.
- MTEP type Heterocycle.
- MTEP type Hydrocarbon.
- MTEP type ChemicalObject.
- MTEP type Thing.
- MTEP type Q8386.
- MTEP comment "3-((2-Methyl-4-thiazolyl)ethynyl)pyridine (MTEP) is a research drug that was developed by Merck & Co. as a selective allosteric antagonist of the metabotropic glutamate receptor subtype mGluR5.".
- MTEP label "MTEP".
- MTEP sameAs m.04zzpbb.
- MTEP sameAs MTEP.
- MTEP sameAs MTEP.
- MTEP sameAs Q13566097.
- MTEP sameAs Q13566097.
- MTEP wasDerivedFrom MTEP?oldid=682070965.
- MTEP depiction Mtep.png.
- MTEP isPrimaryTopicOf MTEP.