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- MSCRAMM abstract "MSCRAMM (acronym for "microbial surface components recognizing adhesive matrix molecules") adhesin proteins mediate the initial attachment of bacteria to host tissue, providing a critical step to establish infection. Examples include protein A, clumping factor A (ClfA), fibronectin binding protein A (FnbpA) from Staphylococcus aureus, SdrG from Staphylococcus epidermidis, M protein from Streptococcus pyogenes, and protein G in other Streptococcus species. All of these MSCRAMMs bind to fibrinogen except protein A, that binds IgG, but also other targets for MSCRAMMs are known, such as fibronectin. Protein M binds to the Fc region of certain antibodies.The MSCRAMMs have mainly been studied in Gram positive pathogens and are promising drug targets. The monoclonal antibody tefibazumab targets ClfA and has been tested in a phase II trial.Staphylococcus aureusAn example for MSCRAMMs is S. aureus. On its surface, protein A is expressed, which binds to the Fc region of IgG antibodies (the default antibody type, dealing with bacterial and viral infections). This has an antiphagocytic effect, i.e. macrophages cannot "see" these bacteria as easily as if they were correctly opsonised by antigen. Also, S. aureus expresses fibronectin-binding proteins, which promote binding to mucosal cells and tissue matrices. This protein is also referred to as clumping factor.".
- MSCRAMM wikiPageID "10081505".
- MSCRAMM wikiPageLength "1614".
- MSCRAMM wikiPageOutDegree "15".
- MSCRAMM wikiPageRevisionID "609777470".
- MSCRAMM wikiPageWikiLink Antibodies.
- MSCRAMM wikiPageWikiLink Antibody.
- MSCRAMM wikiPageWikiLink Category:Bacterial_proteins.
- MSCRAMM wikiPageWikiLink Clinical_trial.
- MSCRAMM wikiPageWikiLink Clumping_factor_A.
- MSCRAMM wikiPageWikiLink Fibronectin_binding_protein_A.
- MSCRAMM wikiPageWikiLink Gram-positive_bacteria.
- MSCRAMM wikiPageWikiLink Gram_positive.
- MSCRAMM wikiPageWikiLink IgG.
- MSCRAMM wikiPageWikiLink Immunoglobulin_G.
- MSCRAMM wikiPageWikiLink M_protein_(Streptococcus).
- MSCRAMM wikiPageWikiLink Protein_A.
- MSCRAMM wikiPageWikiLink Protein_G.
- MSCRAMM wikiPageWikiLink SdrG.
- MSCRAMM wikiPageWikiLink Staphylococcus_aureus.
- MSCRAMM wikiPageWikiLink Staphylococcus_epidermidis.
- MSCRAMM wikiPageWikiLink Streptococcus_pyogenes.
- MSCRAMM wikiPageWikiLink Tefibazumab.
- MSCRAMM wikiPageWikiLinkText "MSCRAMM".
- MSCRAMM hasPhotoCollection MSCRAMM.
- MSCRAMM wikiPageUsesTemplate Template:Protein-stub.
- MSCRAMM wikiPageUsesTemplate Template:Unreferenced.
- MSCRAMM subject Category:Bacterial_proteins.
- MSCRAMM type Article.
- MSCRAMM type Article.
- MSCRAMM comment "MSCRAMM (acronym for "microbial surface components recognizing adhesive matrix molecules") adhesin proteins mediate the initial attachment of bacteria to host tissue, providing a critical step to establish infection. Examples include protein A, clumping factor A (ClfA), fibronectin binding protein A (FnbpA) from Staphylococcus aureus, SdrG from Staphylococcus epidermidis, M protein from Streptococcus pyogenes, and protein G in other Streptococcus species.".
- MSCRAMM label "MSCRAMM".
- MSCRAMM sameAs m.02q15qs.
- MSCRAMM sameAs Q6717708.
- MSCRAMM sameAs Q6717708.
- MSCRAMM wasDerivedFrom MSCRAMM?oldid=609777470.
- MSCRAMM isPrimaryTopicOf MSCRAMM.