Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/MDA5> ?p ?o }
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- MDA5 abstract "MDA5 (Melanoma Differentiation-Associated protein 5) is a RIG-I-like receptor dsRNA helicase enzyme that in humans is encoded by the IFIH1 gene. MDA5 is part of the RIG-I-like receptor (RLR) family, which also includes RIG-I and LGP2, and functions as a pattern recognition receptor (recognizing dsRNA) that is a sensor for viruses. MDA5 typically recognizes dsRNA that is over 2000nts in length. For many viruses, effective MDA5-mediated antiviral responses are dependent on functionally active LGP2. The signaling cascades in MDA5 is initiated via CARD domain.DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon (IFNB) and a protein kinase C-activating compound, mezerein (MEZ). Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation.".
- MDA5 entrezgene "64135".
- MDA5 wikiPageID "14818992".
- MDA5 wikiPageLength "15002".
- MDA5 wikiPageOutDegree "14".
- MDA5 wikiPageRevisionID "678196877".
- MDA5 wikiPageWikiLink Aicardi–Goutières_syndrome.
- MDA5 wikiPageWikiLink Category:Intracellular_receptors.
- MDA5 wikiPageWikiLink Category:RIG-I-like_receptors.
- MDA5 wikiPageWikiLink Dermatomyositis.
- MDA5 wikiPageWikiLink DsRNA.
- MDA5 wikiPageWikiLink Enzyme.
- MDA5 wikiPageWikiLink Gene.
- MDA5 wikiPageWikiLink Helicase.
- MDA5 wikiPageWikiLink Interstitial_lung_disease.
- MDA5 wikiPageWikiLink LGP2.
- MDA5 wikiPageWikiLink Pattern_recognition_receptor.
- MDA5 wikiPageWikiLink RIG-I.
- MDA5 wikiPageWikiLink RIG-I-like_receptor.
- MDA5 wikiPageWikiLink RNA.
- MDA5 wikiPageWikiLink Virus.
- MDA5 wikiPageWikiLinkText "MDA-5".
- MDA5 wikiPageWikiLinkText "MDA5".
- MDA5 wikiPageWikiLinkText "melanoma differentiation-associated protein 5 (MDA5)".
- MDA5 hasPhotoCollection MDA5.
- MDA5 label "Singleton-Merten Syndrome".
- MDA5 requireManualInspection "no".
- MDA5 summaryText "DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp , are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon and a protein kinase C-activating compound, mezerein . Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation.".
- MDA5 target "Singleton Merten Syndrome".
- MDA5 type "mutations_associated_to".
- MDA5 updateCitations "yes".
- MDA5 updatePage "yes".
- MDA5 updateProteinBox "yes".
- MDA5 updateSummary "yes".
- MDA5 wikiPageUsesTemplate Template:Gene-2-stub.
- MDA5 wikiPageUsesTemplate Template:PBB.
- MDA5 wikiPageUsesTemplate Template:PBB_Controls.
- MDA5 wikiPageUsesTemplate Template:PBB_Further_reading.
- MDA5 wikiPageUsesTemplate Template:PBB_Summary.
- MDA5 wikiPageUsesTemplate Template:Pattern_recognition_receptors.
- MDA5 wikiPageUsesTemplate Template:Refbegin.
- MDA5 wikiPageUsesTemplate Template:Refend.
- MDA5 wikiPageUsesTemplate Template:Reflist.
- MDA5 wikiPageUsesTemplate Template:SWL.
- MDA5 subject Category:Intracellular_receptors.
- MDA5 subject Category:RIG-I-like_receptors.
- MDA5 hypernym Enzyme.
- MDA5 type Biomolecule.
- MDA5 type Protein.
- MDA5 type Thing.
- MDA5 type Q206229.
- MDA5 type Q8054.
- MDA5 comment "MDA5 (Melanoma Differentiation-Associated protein 5) is a RIG-I-like receptor dsRNA helicase enzyme that in humans is encoded by the IFIH1 gene. MDA5 is part of the RIG-I-like receptor (RLR) family, which also includes RIG-I and LGP2, and functions as a pattern recognition receptor (recognizing dsRNA) that is a sensor for viruses. MDA5 typically recognizes dsRNA that is over 2000nts in length.".
- MDA5 label "MDA5".
- MDA5 sameAs MDA5.
- MDA5 sameAs m.03gz0__.
- MDA5 sameAs MDA5.
- MDA5 sameAs Q6715117.
- MDA5 sameAs Q6715117.
- MDA5 wasDerivedFrom MDA5?oldid=678196877.
- MDA5 isPrimaryTopicOf MDA5.