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- MATH_domain abstract "The MATH domain, in molecular biology, is a binding domain that was defined originally by a region of homology between otherwise functionally unrelated domains, the intracellular TRAF-C domains of TRAF proteins and a C-terminal region of extracellular meprins A and B.Although apparently functionally unrelated, intracellular TRAFs and extracellular meprins share a conserved region of about 180 residues, the meprin and TRAF homology (MATH) |domain. Meprins are mammalian tissue-specific metalloendopeptidases of the astacin family implicated in developmental, normal and pathological processes by hydrolysing a variety of proteins. Various growth factors, cytokines, and extracellular matrix proteins are substrates for meprins. They are composed of five structural domains: an N-terminal endopeptidase domain, a MAM domain, a MATH domain, an EGF-like domain and a C-terminal transmembrane region. Meprin A and B form membrane bound homo-tetramers whereas homo-oligomers of meprin A are secreted. A proteolytic site adjacent to the MATH domain, only present in meprin A, allows the release of the protein from the membrane.TRAF proteins were first isolated through their ability to interact with TNF receptors. They promote cell survival by the activation of downstream protein kinases and, untimately, transcription factors of the NF-κB and AP-1 family. The TRAF proteins are composed of 3 structural domains: a RING finger in the N-terminal part of the protein, one to seven TRAF zinc fingers in the middle and the MATH domain in the C-terminal part. The MATH domain is necessary and sufficient for self-association and receptor interaction. Through structural analysis, two consensus sequences recognised by the TRAF domain have been defined: a major one, [PSAT]x[QE]E and a minor one, PxQxxD.The structure of the TRAF2 protein reveals a trimeric self-association of the MATH domain. The domain forms a new, light-stranded antiparallel beta sandwich structure. A coiled-coil region adjacent to the MATH domain is also important for the trimerisation. The oligomerisation is essential for establishing appropriate connections to form signalling complexes with TNF receptor-1. The ligand binding surface of TRAF proteins is located in beta-strands 6 and 7.MATH domains are found in a large number of Arabidopsis thaliana sequences, where they often lie alongside s, a structural domain that also promotes oligomerisation.".
- MATH_domain symbol "MATH".
- MATH_domain thumbnail PDB_2cr2_EBI.jpg?width=300.
- MATH_domain wikiPageExternalLink PDOC00021.
- MATH_domain wikiPageID "32712224".
- MATH_domain wikiPageLength "6099".
- MATH_domain wikiPageOutDegree "47".
- MATH_domain wikiPageRevisionID "607209601".
- MATH_domain wikiPageWikiLink Antiparallel_(biochemistry).
- MATH_domain wikiPageWikiLink Apoptosis.
- MATH_domain wikiPageWikiLink Arabidopsis_thaliana.
- MATH_domain wikiPageWikiLink Astacin.
- MATH_domain wikiPageWikiLink POZ_domain.
- MATH_domain wikiPageWikiLink Binding_domain.
- MATH_domain wikiPageWikiLink Biological_membrane.
- MATH_domain wikiPageWikiLink Biomolecular_structure.
- MATH_domain wikiPageWikiLink Category:Protein_domains.
- MATH_domain wikiPageWikiLink Cell_(biology).
- MATH_domain wikiPageWikiLink Cell_growth.
- MATH_domain wikiPageWikiLink Cell_membrane.
- MATH_domain wikiPageWikiLink Cell_signaling.
- MATH_domain wikiPageWikiLink Cell_signalling.
- MATH_domain wikiPageWikiLink Cis-Regulatory_element.
- MATH_domain wikiPageWikiLink Cis-regulatory_element.
- MATH_domain wikiPageWikiLink Coiled_coil.
- MATH_domain wikiPageWikiLink Consensus_sequence.
- MATH_domain wikiPageWikiLink Conserved_sequence.
- MATH_domain wikiPageWikiLink Endopeptidase.
- MATH_domain wikiPageWikiLink Extracellular.
- MATH_domain wikiPageWikiLink Extracellular_matrix.
- MATH_domain wikiPageWikiLink Gene_activation.
- MATH_domain wikiPageWikiLink Homology_(biology).
- MATH_domain wikiPageWikiLink Intracellular.
- MATH_domain wikiPageWikiLink Ligand_(biochemistry).
- MATH_domain wikiPageWikiLink Ligand_binding.
- MATH_domain wikiPageWikiLink MATH.
- MATH_domain wikiPageWikiLink MEP1B.
- MATH_domain wikiPageWikiLink Mammal.
- MATH_domain wikiPageWikiLink Mammalia.
- MATH_domain wikiPageWikiLink Mathematics.
- MATH_domain wikiPageWikiLink Meprin_A.
- MATH_domain wikiPageWikiLink Molecular_biology.
- MATH_domain wikiPageWikiLink Nuclear_receptor.
- MATH_domain wikiPageWikiLink Pathology.
- MATH_domain wikiPageWikiLink Protein.
- MATH_domain wikiPageWikiLink Protein-protein_interaction.
- MATH_domain wikiPageWikiLink Protein_kinase.
- MATH_domain wikiPageWikiLink Proteins.
- MATH_domain wikiPageWikiLink Protein–protein_interaction.
- MATH_domain wikiPageWikiLink Proteolysis.
- MATH_domain wikiPageWikiLink Receptor_(biochemistry).
- MATH_domain wikiPageWikiLink Regulation_of_gene_expression.
- MATH_domain wikiPageWikiLink Secondary_structure.
- MATH_domain wikiPageWikiLink Secreted.
- MATH_domain wikiPageWikiLink Secretion.
- MATH_domain wikiPageWikiLink Substrate_(biochemistry).
- MATH_domain wikiPageWikiLink Substrate_(chemistry).
- MATH_domain wikiPageWikiLink TNF_receptor_associated_factor.
- MATH_domain wikiPageWikiLink Transcription_factor.
- MATH_domain wikiPageWikiLink Upstream_and_downstream_(DNA).
- MATH_domain wikiPageWikiLink Zinc_finger.
- MATH_domain wikiPageWikiLinkText "MATH".
- MATH_domain caption "solution structure of n-terminal domain of speckle-type poz protein".
- MATH_domain cdd "cd00121".
- MATH_domain hasPhotoCollection MATH_domain.
- MATH_domain interpro "IPR002083".
- MATH_domain name "MATH".
- MATH_domain pfam "PF00917".
- MATH_domain pfamClan "CL0389".
- MATH_domain scop "1".
- MATH_domain symbol "MATH".
- MATH_domain wikiPageUsesTemplate Template:Infobox_protein_family.
- MATH_domain wikiPageUsesTemplate Template:InterPro_content.
- MATH_domain wikiPageUsesTemplate Template:Reflist.
- MATH_domain subject Category:Protein_domains.
- MATH_domain hypernym Domain.
- MATH_domain type Biomolecule.
- MATH_domain type Protein.
- MATH_domain type Chemical.
- MATH_domain type Domain.
- MATH_domain type Thing.
- MATH_domain type Q206229.
- MATH_domain type Q8054.
- MATH_domain comment "The MATH domain, in molecular biology, is a binding domain that was defined originally by a region of homology between otherwise functionally unrelated domains, the intracellular TRAF-C domains of TRAF proteins and a C-terminal region of extracellular meprins A and B.Although apparently functionally unrelated, intracellular TRAFs and extracellular meprins share a conserved region of about 180 residues, the meprin and TRAF homology (MATH) |domain.".
- MATH_domain label "MATH domain".
- MATH_domain sameAs m.0h3mzbb.
- MATH_domain sameAs Q6714555.
- MATH_domain sameAs Q6714555.
- MATH_domain wasDerivedFrom MATH_domain?oldid=607209601.
- MATH_domain depiction PDB_2cr2_EBI.jpg.
- MATH_domain isPrimaryTopicOf MATH_domain.