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- MAP3K4 abstract "Mitogen-activated protein kinase kinase kinase 4 is an enzyme that in humans is encoded by the MAP3K4 gene.The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 (p38α) and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 (p38α) and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 (MKK6) and SERK1 (MKK4), MAPKKs that activate CSBP2 (p38α) and JNK, respectively but cannot phosphorylate PRKMK1 (MKK1), an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the p38 MAPK pathway, and a minor mediator of the JNK pathway. Two alternatively spliced transcripts encoding distinct isoforms have been described.".
- MAP3K4 entrezgene "4216".
- MAP3K4 wikiPageExternalLink nature377_3.pdf.
- MAP3K4 wikiPageID "14795209".
- MAP3K4 wikiPageLength "10632".
- MAP3K4 wikiPageOutDegree "6".
- MAP3K4 wikiPageRevisionID "673298875".
- MAP3K4 wikiPageWikiLink Enzyme.
- MAP3K4 wikiPageWikiLink GADD45A.
- MAP3K4 wikiPageWikiLink GADD45B.
- MAP3K4 wikiPageWikiLink GADD45G.
- MAP3K4 wikiPageWikiLink Gene.
- MAP3K4 wikiPageWikiLink Protein-protein_interaction.
- MAP3K4 wikiPageWikiLink Protein–protein_interaction.
- MAP3K4 wikiPageWikiLinkText "MAP3K4".
- MAP3K4 wikiPageWikiLinkText "MEKK4".
- MAP3K4 wikiPageWikiLinkText "MTK1/MEKK4".
- MAP3K4 hasPhotoCollection MAP3K4.
- MAP3K4 requireManualInspection "no".
- MAP3K4 summaryText "The central core of each mitogen-activated protein kinase pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase phosphorylates and activates a specific MAPK kinase , which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1 , MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1 , an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the p38 MAPK pathway, and a minor mediator of the JNK pathway. Two alternatively spliced transcripts encoding distinct isoforms have been described.".
- MAP3K4 updateCitations "yes".
- MAP3K4 updatePage "yes".
- MAP3K4 updateProteinBox "yes".
- MAP3K4 updateSummary "yes".
- MAP3K4 wikiPageUsesTemplate Template:Gene-6-stub.
- MAP3K4 wikiPageUsesTemplate Template:PBB.
- MAP3K4 wikiPageUsesTemplate Template:PBB_Controls.
- MAP3K4 wikiPageUsesTemplate Template:PBB_Further_reading.
- MAP3K4 wikiPageUsesTemplate Template:PBB_Summary.
- MAP3K4 wikiPageUsesTemplate Template:Refbegin.
- MAP3K4 wikiPageUsesTemplate Template:Refend.
- MAP3K4 wikiPageUsesTemplate Template:Reflist.
- MAP3K4 hypernym Enzyme.
- MAP3K4 type Biomolecule.
- MAP3K4 type Protein.
- MAP3K4 type Thing.
- MAP3K4 type Q206229.
- MAP3K4 type Q8054.
- MAP3K4 comment "Mitogen-activated protein kinase kinase kinase 4 is an enzyme that in humans is encoded by the MAP3K4 gene.The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK.".
- MAP3K4 label "MAP3K4".
- MAP3K4 sameAs m.03gy5kv.
- MAP3K4 sameAs Q6714369.
- MAP3K4 sameAs Q6714369.
- MAP3K4 wasDerivedFrom MAP3K4?oldid=673298875.
- MAP3K4 isPrimaryTopicOf MAP3K4.