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- Losmapimod abstract "Losmapimod (GW856553X) is a drug developed by GlaxoSmithKline which acts as a selective inhibitor of the enzyme family known as p38 mitogen-activated protein kinases.p38 mitogen-activated protein kinases are mediators of inflammation. A Phase II human clinical trial for the treatment of COPD (chronic obstructive pulmonary disease) is underway. Inhibiting these enzymes has been shown to produce antidepressant and antipsychotic effects in animal studies, with the mechanism thought to involve increased neurogenesis probably related to BDNF release. Losmapimod has completed Phase II human clinical trials for the treatment of depression although its safety and efficacy have yet to be proven in further trials.Losmapimod is also being studied for cardiovascular disease. A Phase II trial to study its effects in myocardial infarction (heart attack) is ongoing.".
- Losmapimod casNumber "585543-15-3".
- Losmapimod fdaUniiCode "F2DQF16BXE".
- Losmapimod iupacName "6-[5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide".
- Losmapimod pubchem "11552706".
- Losmapimod thumbnail Losmapimod.svg?width=300.
- Losmapimod wikiPageID "24932026".
- Losmapimod wikiPageLength "4707".
- Losmapimod wikiPageOutDegree "15".
- Losmapimod wikiPageRevisionID "667246630".
- Losmapimod wikiPageWikiLink Antidepressant.
- Losmapimod wikiPageWikiLink Antipsychotic.
- Losmapimod wikiPageWikiLink BDNF.
- Losmapimod wikiPageWikiLink Brain-derived_neurotrophic_factor.
- Losmapimod wikiPageWikiLink COPD.
- Losmapimod wikiPageWikiLink Category:Protein_kinase_inhibitors.
- Losmapimod wikiPageWikiLink Chronic_obstructive_pulmonary_disease.
- Losmapimod wikiPageWikiLink Clinical_trial.
- Losmapimod wikiPageWikiLink Clinical_trials.
- Losmapimod wikiPageWikiLink Depression_(mood).
- Losmapimod wikiPageWikiLink Enzyme.
- Losmapimod wikiPageWikiLink GlaxoSmithKline.
- Losmapimod wikiPageWikiLink Inflammation.
- Losmapimod wikiPageWikiLink Myocardial_infarction.
- Losmapimod wikiPageWikiLink Neurogenesis.
- Losmapimod wikiPageWikiLink P38_mitogen-activated_protein_kinases.
- Losmapimod wikiPageWikiLinkText "losmapimod".
- Losmapimod c "22".
- Losmapimod casNumber "585543".
- Losmapimod chembl "1088752".
- Losmapimod chemspiderid "9727484".
- Losmapimod f "1".
- Losmapimod h "26".
- Losmapimod hasPhotoCollection Losmapimod.
- Losmapimod inchi "1".
- Losmapimod inchikey "KKYABQBFGDZVNQ-UHFFFAOYAE".
- Losmapimod iupacName "6".
- Losmapimod iupharLigand "7835".
- Losmapimod kegg "D09639".
- Losmapimod legalStatus "investigational new drug".
- Losmapimod molecularWeight "383.458".
- Losmapimod n "3".
- Losmapimod o "2".
- Losmapimod pubchem "11552706".
- Losmapimod smiles "C3CC3NCccc1-cncc2CNCCC".
- Losmapimod stdinchi "1".
- Losmapimod stdinchikey "KKYABQBFGDZVNQ-UHFFFAOYSA-N".
- Losmapimod unii "F2DQF16BXE".
- Losmapimod verifiedfields "changed".
- Losmapimod verifiedrevid "444926440".
- Losmapimod watchedfields "changed".
- Losmapimod wikiPageUsesTemplate Template:Drugbox.
- Losmapimod wikiPageUsesTemplate Template:Reflist.
- Losmapimod subject Category:Protein_kinase_inhibitors.
- Losmapimod hypernym Drug.
- Losmapimod type Article.
- Losmapimod type ChemicalSubstance.
- Losmapimod type Drug.
- Losmapimod type Article.
- Losmapimod type Chemical.
- Losmapimod type Inhibitor.
- Losmapimod type ChemicalObject.
- Losmapimod type Thing.
- Losmapimod type Q8386.
- Losmapimod comment "Losmapimod (GW856553X) is a drug developed by GlaxoSmithKline which acts as a selective inhibitor of the enzyme family known as p38 mitogen-activated protein kinases.p38 mitogen-activated protein kinases are mediators of inflammation. A Phase II human clinical trial for the treatment of COPD (chronic obstructive pulmonary disease) is underway.".
- Losmapimod label "Losmapimod".
- Losmapimod sameAs m.09ggpbg.
- Losmapimod sameAs Losmapimod.
- Losmapimod sameAs Losmapimod.
- Losmapimod sameAs Q6683687.
- Losmapimod sameAs Q6683687.
- Losmapimod wasDerivedFrom Losmapimod?oldid=667246630.
- Losmapimod depiction Losmapimod.svg.
- Losmapimod isPrimaryTopicOf Losmapimod.