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- Loreclezole abstract "Loreclezole is a sedative and an anticonvulsant which acts as a GABAA receptor positive allosteric modulator. The binding site of loreclezole has been shown experimentally to be shared by valerenic acid, an extract of the root of the valerian plant. Structurally, loreclezole is a triazole derivative. In animal seizure models, loreclezole is protective against pentylenetetrazol seizures but is less active in the maximal electroshock test. In addition, at low, nontoxic doses, the drug has anti-absence activity in a genetic model of generalized absence epilepsy. Consequently, loreclezole has a profile of activity similar to that of benzodiazepines. A potential benzodiazepine-like interaction with GABA receptors is suggested by the observation that the anticonvulsant effects of loreclezole can be reversed by benzodiazepine receptor inverse agonists. The benzodiazepine antagonist flumazenil, however, fails to alter the anticonvulsant activity of loreclezole, indicating that loreclezole is not a benzodiazepine receptor agonist. Using native rat and cloned human GABA-A receptors, loreclezole strongly potentiated GABA-activated chloride current. However, activity of the drug did not require the presence of the γ-subunit and was not blocked by flumazenil, confirming that loreclezole does not interact with the benzodiazepine recognition site.".
- Loreclezole atcPrefix "none".
- Loreclezole casNumber "117857-45-1".
- Loreclezole fdaUniiCode "6DJ32STZ5W".
- Loreclezole iupacName "1-[(Z)-2-chloro-2-(2,4-dichlorophenyl)vinyl]-1H-1,2,4-triazole".
- Loreclezole pubchem "3034012".
- Loreclezole thumbnail Loreclezole.svg?width=300.
- Loreclezole wikiPageID "14475850".
- Loreclezole wikiPageLength "4691".
- Loreclezole wikiPageOutDegree "12".
- Loreclezole wikiPageRevisionID "679031228".
- Loreclezole wikiPageWikiLink Allosteric_modulator.
- Loreclezole wikiPageWikiLink Anticonvulsant.
- Loreclezole wikiPageWikiLink Benzodiazepine.
- Loreclezole wikiPageWikiLink Benzodiazepines.
- Loreclezole wikiPageWikiLink Category:GABAA-rho_receptor_negative_allosteric_modulators.
- Loreclezole wikiPageWikiLink Category:GABAA_receptor_positive_allosteric_modulators.
- Loreclezole wikiPageWikiLink Category:Organochlorides.
- Loreclezole wikiPageWikiLink Category:Sedatives.
- Loreclezole wikiPageWikiLink Category:Triazoles.
- Loreclezole wikiPageWikiLink GABAA_receptor.
- Loreclezole wikiPageWikiLink Positive_allosteric_modulator.
- Loreclezole wikiPageWikiLink Sedative.
- Loreclezole wikiPageWikiLink Valerenic_acid.
- Loreclezole wikiPageWikiLink Valerian_(herb).
- Loreclezole wikiPageWikiLinkText "Loreclezole".
- Loreclezole wikiPageWikiLinkText "loreclezole".
- Loreclezole atcPrefix "none".
- Loreclezole c "10".
- Loreclezole casNumber "117857".
- Loreclezole chemspiderid "2298566".
- Loreclezole cl "3".
- Loreclezole h "6".
- Loreclezole hasPhotoCollection Loreclezole.
- Loreclezole iupacName "1".
- Loreclezole iupharLigand "5466".
- Loreclezole kegg "D04780".
- Loreclezole molecularWeight "274.534".
- Loreclezole n "3".
- Loreclezole pubchem "3034012".
- Loreclezole stdinchi "1".
- Loreclezole stdinchikey "XGLHZTBDUXXHOM-WMZJFQQLSA-N".
- Loreclezole unii "6".
- Loreclezole verifiedrevid "448039092".
- Loreclezole width "180".
- Loreclezole wikiPageUsesTemplate Template:Drugbox.
- Loreclezole wikiPageUsesTemplate Template:GABAAR_PAMs.
- Loreclezole wikiPageUsesTemplate Template:GABAergics.
- Loreclezole wikiPageUsesTemplate Template:Hypnotics_and_sedatives.
- Loreclezole wikiPageUsesTemplate Template:Reflist.
- Loreclezole wikiPageUsesTemplate Template:Sedative-stub.
- Loreclezole subject Category:GABAA-rho_receptor_negative_allosteric_modulators.
- Loreclezole subject Category:GABAA_receptor_positive_allosteric_modulators.
- Loreclezole subject Category:Organochlorides.
- Loreclezole subject Category:Sedatives.
- Loreclezole subject Category:Triazoles.
- Loreclezole hypernym Sedative.
- Loreclezole type ChemicalSubstance.
- Loreclezole type Drug.
- Loreclezole type Agonist.
- Loreclezole type Azole.
- Loreclezole type Drug.
- Loreclezole type Organohalide.
- Loreclezole type Organohalide.
- Loreclezole type ChemicalObject.
- Loreclezole type Thing.
- Loreclezole type Q8386.
- Loreclezole comment "Loreclezole is a sedative and an anticonvulsant which acts as a GABAA receptor positive allosteric modulator. The binding site of loreclezole has been shown experimentally to be shared by valerenic acid, an extract of the root of the valerian plant. Structurally, loreclezole is a triazole derivative. In animal seizure models, loreclezole is protective against pentylenetetrazol seizures but is less active in the maximal electroshock test.".
- Loreclezole label "Loreclezole".
- Loreclezole sameAs m.03d4rh1.
- Loreclezole sameAs Loreklezol.
- Loreclezole sameAs Loreklezol.
- Loreclezole sameAs Q6680282.
- Loreclezole sameAs Q6680282.
- Loreclezole wasDerivedFrom Loreclezole?oldid=679031228.
- Loreclezole depiction Loreclezole.svg.
- Loreclezole isPrimaryTopicOf Loreclezole.