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- Lim_kinase abstract "LIM kinase-1 (LIMK1) and LIM kinase-2 (LIMK2) are actin-binding kinases that phosphorylate members of the ADF/cofilin family of actin binding and filament severing proteins. ADF/cofilin are the only substrates yet identified for the LIM kinases. LIM kinases directly phosphorylate and inactivate members of the cofilin family, resulting in stabilization of filamentous (F)-actin. Lim kinases are activated by signaling through small GTPases of the Rho family. Upstream, LIMK1 is regulated by Pak1, and LIMK2 by the Rho-dependent kinase ROCK. Lim Kinases are activated by PAK (p21-activated kinase). Recent work indicates that LIMK activity is also modulated by HIV-1 viral proteins.There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is likely to be a component of an intracellular signaling pathway and may be involved in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome.".
- Lim_kinase wikiPageID "7725415".
- Lim_kinase wikiPageLength "1930".
- Lim_kinase wikiPageOutDegree "16".
- Lim_kinase wikiPageRevisionID "547998857".
- Lim_kinase wikiPageWikiLink Actin.
- Lim_kinase wikiPageWikiLink Category:EC_2.7.1.
- Lim_kinase wikiPageWikiLink Cofilin.
- Lim_kinase wikiPageWikiLink DNA.
- Lim_kinase wikiPageWikiLink Kinase.
- Lim_kinase wikiPageWikiLink LIMK1.
- Lim_kinase wikiPageWikiLink LIMK2.
- Lim_kinase wikiPageWikiLink LIM_kinase.
- Lim_kinase wikiPageWikiLink Protein.
- Lim_kinase wikiPageWikiLink RNA.
- Lim_kinase wikiPageWikiLink Structural_motif.
- Lim_kinase wikiPageWikiLink Substrate_(biochemistry).
- Lim_kinase wikiPageWikiLink Substrate_(chemistry).
- Lim_kinase wikiPageWikiLink Williams_syndrome.
- Lim_kinase wikiPageWikiLink Zinc.
- Lim_kinase wikiPageWikiLinkText "Lim kinase".
- Lim_kinase hasPhotoCollection Lim_kinase.
- Lim_kinase wikiPageUsesTemplate Template:MeshName.
- Lim_kinase wikiPageUsesTemplate Template:Reflist.
- Lim_kinase subject Category:EC_2.7.1.
- Lim_kinase hypernym Kinases.
- Lim_kinase type Protein.
- Lim_kinase comment "LIM kinase-1 (LIMK1) and LIM kinase-2 (LIMK2) are actin-binding kinases that phosphorylate members of the ADF/cofilin family of actin binding and filament severing proteins. ADF/cofilin are the only substrates yet identified for the LIM kinases. LIM kinases directly phosphorylate and inactivate members of the cofilin family, resulting in stabilization of filamentous (F)-actin. Lim kinases are activated by signaling through small GTPases of the Rho family.".
- Lim_kinase label "Lim kinase".
- Lim_kinase sameAs m.026b0w4.
- Lim_kinase sameAs Q17121083.
- Lim_kinase sameAs Q17121083.
- Lim_kinase wasDerivedFrom Lim_kinase?oldid=547998857.
- Lim_kinase isPrimaryTopicOf Lim_kinase.