Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Levofenfluramine> ?p ?o }
- Levofenfluramine abstract "Levofenfluramine (INN), or (−)-3-trifluoromethyl-N-ethylamphetamine, also known as (−)-fenfluramine or (R)-fenfluramine, is a drug of the amphetamine family that, itself (i.e., in enantiopure form), was never marketed. It is the levorotatory enantiomer of fenfluramine, the racemic form of the compound, whereas the dextrorotatory enantiomer is dexfenfluramine. Both fenfluramine and dexfenfluramine are anorectic agents that have been used clinically in the treatment of obesity (and hence, levofenfluramine has been as well since it is a component of fenfluramine). However, they have since been discontinued due to reports of causing cardiovascular conditions such as valvular heart disease and pulmonary hypertension, adverse effects that are likely to be caused by excessive stimulation of 5-HT2B receptors expressed on heart valves.Dexfenfluramine is believed to be solely responsible for the appetite suppressant properties of fenfluramine, of which it has been demonstrated to mediate predominantly via activation of postsynaptic 5-HT1B and 5-HT2C receptors through a combination of indirect serotonin releasing agent and direct serotonin receptor agonist activities (the latter of which are mediated fully by its active metabolite dexnorfenfluramine). Contrarily, levofenfluramine is thought to contribute only to unwanted side effects. Paradoxically, however, it has been shown that levofenfluramine too acts as a relatively potent releaser of serotonin, though with approximately 1/3rd of the efficacy of dexfenfluramine, As such, it would be expected to possess some degree of appetite suppressant properties as well, yet it does not. A potential explanation as to why levofenfluramine is not similarly an effective anorectic is that it has also been found to behave as a dopamine receptor antagonist, which, as dopamine antagonists like atypical antipsychotics are associated with causing increased appetite and weight gain—effects that their actions on dopamine receptors have been implicated in playing a role in the development of, is an action that could in theory cancel out the hypothetical serotonergically-mediated appetite suppressant effects of the compound. Of course, this is merely speculation and has not been proven.Levonorfenfluramine, an active metabolite of levofenfluramine, is also a fairly potent serotonin releasing agent (with a potency of approximately 1/2 that of norfenfluramine and 1/6th that of dexfenfluramine) and, similarly to dexnorfenfluramine, 5-HT2B and 5-HT2C receptor agonist, as well as a somewhat less potent norepinephrine reuptake inhibitor (about 1/2 that of its efficacy as a serotonin releaser). As such, likely contributes significantly to the biological activity—though not necessarily appetite suppressant effects—of not only levofenfluramine but of racemic fenfluramine as well. In contrast to levonorfenfluramine, levofenfluramine is virtually inactive as a reuptake inhibitor or releaser of norepinephrine, and neither compound has any effect on dopamine reuptake or release.".
- Levofenfluramine atcPrefix "None".
- Levofenfluramine casNumber "37577-24-5".
- Levofenfluramine casSupplemental "5220-89-3 (HCl)".
- Levofenfluramine iupacName "(2R)-N-ethyl-1-[3-(trifluoromethyl)phenyl]-2-propanamine".
- Levofenfluramine pubchem "65801".
- Levofenfluramine thumbnail Levofenfluramine.svg?width=300.
- Levofenfluramine wikiPageID "35804370".
- Levofenfluramine wikiPageLength "10284".
- Levofenfluramine wikiPageOutDegree "52".
- Levofenfluramine wikiPageRevisionID "678946136".
- Levofenfluramine wikiPageWikiLink 5-HT1B_receptor.
- Levofenfluramine wikiPageWikiLink 5-HT2B_receptor.
- Levofenfluramine wikiPageWikiLink 5-HT2C_receptor.
- Levofenfluramine wikiPageWikiLink 5-HT_receptor.
- Levofenfluramine wikiPageWikiLink Active_metabolite.
- Levofenfluramine wikiPageWikiLink Adverse_effect.
- Levofenfluramine wikiPageWikiLink Agonist.
- Levofenfluramine wikiPageWikiLink Anorectic.
- Levofenfluramine wikiPageWikiLink Appetite_suppressant.
- Levofenfluramine wikiPageWikiLink Atypical_antipsychotic.
- Levofenfluramine wikiPageWikiLink Biological_activity.
- Levofenfluramine wikiPageWikiLink Cardiovascular_disease.
- Levofenfluramine wikiPageWikiLink Category:Dopamine_antagonists.
- Levofenfluramine wikiPageWikiLink Category:Enantiopure_drugs.
- Levofenfluramine wikiPageWikiLink Category:Organofluorides.
- Levofenfluramine wikiPageWikiLink Category:Serotonin_receptor_agonists.
- Levofenfluramine wikiPageWikiLink Category:Serotonin_releasing_agents.
- Levofenfluramine wikiPageWikiLink Category:Substituted_amphetamines.
- Levofenfluramine wikiPageWikiLink Category:Withdrawn_drugs.
- Levofenfluramine wikiPageWikiLink Chemical_synapse.
- Levofenfluramine wikiPageWikiLink Dexfenfluramine.
- Levofenfluramine wikiPageWikiLink Dexnorfenfluramine.
- Levofenfluramine wikiPageWikiLink Dextrorotation_and_levorotation.
- Levofenfluramine wikiPageWikiLink Dextrorotatory.
- Levofenfluramine wikiPageWikiLink Dopamine.
- Levofenfluramine wikiPageWikiLink Dopamine_receptor.
- Levofenfluramine wikiPageWikiLink Dosage_form.
- Levofenfluramine wikiPageWikiLink Drug.
- Levofenfluramine wikiPageWikiLink Drug_form.
- Levofenfluramine wikiPageWikiLink Enantiomer.
- Levofenfluramine wikiPageWikiLink Enantiopure.
- Levofenfluramine wikiPageWikiLink Fenfluramine.
- Levofenfluramine wikiPageWikiLink Heart_valve.
- Levofenfluramine wikiPageWikiLink Hydrochloride.
- Levofenfluramine wikiPageWikiLink Hyperphagia.
- Levofenfluramine wikiPageWikiLink International_Nonproprietary_Name.
- Levofenfluramine wikiPageWikiLink Levonorfenfluramine.
- Levofenfluramine wikiPageWikiLink Levorotatory.
- Levofenfluramine wikiPageWikiLink Norepinephrine.
- Levofenfluramine wikiPageWikiLink Norepinephrine_reuptake_inhibitor.
- Levofenfluramine wikiPageWikiLink Norfenfluramine.
- Levofenfluramine wikiPageWikiLink Obesity.
- Levofenfluramine wikiPageWikiLink Polyphagia.
- Levofenfluramine wikiPageWikiLink Postsynaptic.
- Levofenfluramine wikiPageWikiLink Potency_(pharmacology).
- Levofenfluramine wikiPageWikiLink Pulmonary_hypertension.
- Levofenfluramine wikiPageWikiLink Racemic.
- Levofenfluramine wikiPageWikiLink Racemic_mixture.
- Levofenfluramine wikiPageWikiLink Receptor_antagonist.
- Levofenfluramine wikiPageWikiLink Serotonin.
- Levofenfluramine wikiPageWikiLink Serotonin_receptor.
- Levofenfluramine wikiPageWikiLink Serotonin_releasing_agent.
- Levofenfluramine wikiPageWikiLink Side_effect.
- Levofenfluramine wikiPageWikiLink Substituted_amphetamine.
- Levofenfluramine wikiPageWikiLink Valvular_heart_disease.
- Levofenfluramine wikiPageWikiLink Weight_gain.
- Levofenfluramine wikiPageWikiLinkText "Levofenfluramine".
- Levofenfluramine wikiPageWikiLinkText "levofenfluramine".
- Levofenfluramine atcPrefix "None".
- Levofenfluramine c "12".
- Levofenfluramine casNumber "37577".
- Levofenfluramine casSupplemental "5220".
- Levofenfluramine chemspiderid "59217".
- Levofenfluramine f "3".
- Levofenfluramine h "16".
- Levofenfluramine hasPhotoCollection Levofenfluramine.
- Levofenfluramine inchi "1".
- Levofenfluramine inchikey "DBGIVFWFUFKIQN-SECBINFHBR".
- Levofenfluramine iupacName "-N-ethyl-1-[3-phenyl]-2-propanamine".
- Levofenfluramine molecularWeight "231.257".
- Levofenfluramine n "1".
- Levofenfluramine pubchem "65801".
- Levofenfluramine smiles "FCc1ccccC[C@H]C".
- Levofenfluramine stdinchi "1".
- Levofenfluramine stdinchikey "DBGIVFWFUFKIQN-SECBINFHSA-N".
- Levofenfluramine wikiPageUsesTemplate Template:Drugbox.
- Levofenfluramine wikiPageUsesTemplate Template:Phenethylamines.
- Levofenfluramine wikiPageUsesTemplate Template:Reflist.
- Levofenfluramine wikiPageUsesTemplate Template:Serotonergics.
- Levofenfluramine subject Category:Dopamine_antagonists.
- Levofenfluramine subject Category:Enantiopure_drugs.
- Levofenfluramine subject Category:Organofluorides.
- Levofenfluramine subject Category:Serotonin_receptor_agonists.
- Levofenfluramine subject Category:Serotonin_releasing_agents.
- Levofenfluramine subject Category:Substituted_amphetamines.
- Levofenfluramine subject Category:Withdrawn_drugs.
- Levofenfluramine hypernym Drug.
- Levofenfluramine type Article.
- Levofenfluramine type ChemicalSubstance.