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- Lapaquistat abstract "Lapaquistat (TAK-475) is a cholesterol-lowering drug. Unlike statins, which inhibit HMG-CoA reductase, lapaquistat metabolites inhibit squalene synthase, which is further downstream in the synthesis of cholesterol. It is hoped that side effects can be reduced by not disturbing the mevalonate pathway, which is important for other biochemical molecules besides cholesterol.However, there is increasing evidence that statins (which inhibit the mevalonate pathway) may be clinically useful because they affect these other molecules (including protein prenylation).On March 28, 2008, Takeda halted further development of lapaquistat. While effective at lowering low-density lipoprotein cholesterol in a dose-dependent manner, development of the drug was ceased over potential hepatic safety issues.".
- Lapaquistat atcPrefix "none".
- Lapaquistat casNumber "189059-71-0".
- Lapaquistat fdaUniiCode "PEZ79BV72X".
- Lapaquistat iupacName "(1-{[(3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl}piperidin-4-yl)acetic acid".
- Lapaquistat pubchem "9960389".
- Lapaquistat thumbnail Lapaquistat.svg?width=300.
- Lapaquistat wikiPageID "14387852".
- Lapaquistat wikiPageLength "3731".
- Lapaquistat wikiPageOutDegree "11".
- Lapaquistat wikiPageRevisionID "678943970".
- Lapaquistat wikiPageWikiLink Category:Amides.
- Lapaquistat wikiPageWikiLink Category:Benzoxazepines.
- Lapaquistat wikiPageWikiLink Category:Chloroarenes.
- Lapaquistat wikiPageWikiLink Category:Hypolipidemic_agents.
- Lapaquistat wikiPageWikiLink Category:Phenol_ethers.
- Lapaquistat wikiPageWikiLink Category:Piperidines.
- Lapaquistat wikiPageWikiLink Cholesterol.
- Lapaquistat wikiPageWikiLink Farnesyl-diphosphate_farnesyltransferase.
- Lapaquistat wikiPageWikiLink HMG-CoA_reductase.
- Lapaquistat wikiPageWikiLink Mevalonate_pathway.
- Lapaquistat wikiPageWikiLink Squalene_synthase.
- Lapaquistat wikiPageWikiLink Statin.
- Lapaquistat wikiPageWikiLinkText "Lapaquistat".
- Lapaquistat wikiPageWikiLinkText "TAK-475".
- Lapaquistat atcPrefix "none".
- Lapaquistat c "31".
- Lapaquistat casNumber "189059".
- Lapaquistat chembl "341976".
- Lapaquistat chemspiderid "8135996".
- Lapaquistat cl "1".
- Lapaquistat h "39".
- Lapaquistat hasPhotoCollection Lapaquistat.
- Lapaquistat inchi "1".
- Lapaquistat inchikey "HDGUKVZPMPJBFK-LEAFIULHBZ".
- Lapaquistat iupacName "acetic acid".
- Lapaquistat molecularWeight "603.103".
- Lapaquistat n "2".
- Lapaquistat o "8".
- Lapaquistat pubchem "9960389".
- Lapaquistat smiles "O=CCC4CCNCC4".
- Lapaquistat stdinchi "1".
- Lapaquistat stdinchikey "HDGUKVZPMPJBFK-LEAFIULHSA-N".
- Lapaquistat unii "PEZ79BV72X".
- Lapaquistat verifiedfields "changed".
- Lapaquistat verifiedrevid "462088993".
- Lapaquistat wikiPageUsesTemplate Template:Cardiovascular-drug-stub.
- Lapaquistat wikiPageUsesTemplate Template:Cite_journal.
- Lapaquistat wikiPageUsesTemplate Template:Drugbox.
- Lapaquistat wikiPageUsesTemplate Template:Lipid_modifying_agents.
- Lapaquistat wikiPageUsesTemplate Template:Reflist.
- Lapaquistat subject Category:Amides.
- Lapaquistat subject Category:Benzoxazepines.
- Lapaquistat subject Category:Chloroarenes.
- Lapaquistat subject Category:Hypolipidemic_agents.
- Lapaquistat subject Category:Phenol_ethers.
- Lapaquistat subject Category:Piperidines.
- Lapaquistat hypernym Drug.
- Lapaquistat type Agent.
- Lapaquistat type ChemicalSubstance.
- Lapaquistat type Drug.
- Lapaquistat type Group.
- Lapaquistat type Agent.
- Lapaquistat type Amide.
- Lapaquistat type Chemical.
- Lapaquistat type Drug.
- Lapaquistat type Ether.
- Lapaquistat type Group.
- Lapaquistat type Heterocycle.
- Lapaquistat type Organohalide.
- Lapaquistat type Organohalide.
- Lapaquistat type ChemicalObject.
- Lapaquistat type Thing.
- Lapaquistat type Q8386.
- Lapaquistat comment "Lapaquistat (TAK-475) is a cholesterol-lowering drug. Unlike statins, which inhibit HMG-CoA reductase, lapaquistat metabolites inhibit squalene synthase, which is further downstream in the synthesis of cholesterol.".
- Lapaquistat label "Lapaquistat".
- Lapaquistat sameAs ラパキスタット.
- Lapaquistat sameAs m.03d2785.
- Lapaquistat sameAs Lapakvistat.
- Lapaquistat sameAs Lapakvistat.
- Lapaquistat sameAs Q6488102.
- Lapaquistat sameAs Q6488102.
- Lapaquistat wasDerivedFrom Lapaquistat?oldid=678943970.
- Lapaquistat depiction Lapaquistat.svg.
- Lapaquistat isPrimaryTopicOf Lapaquistat.