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- LY294002 abstract "LY294002 is a morpholine-containing chemical compound that is a potent inhibitor of numerous proteins, and a strong inhibitor of phosphoinositide 3-kinases (PI3Ks). It is generally considered a non-selective research tool, and should not be used for experiments aiming to target PI3K uniquely. Two of these are the proto-oncogene serine/threonine-protein kinase (PIM1) and the phosphatidylinositol-4,5-bisphosphate 3-kinase P110 gamma|catalytic subunit gamma isoform. With an IC50 of 1.4 µM it is somewhat less potent than wortmannin, another well-known PI3 kinase inhibitor. However, LY294002 is a reversible inhibitor of PI3K whereas wortmannin acts irreversibly. Application of LY294002 causes a substantial acceleration of MEPP frequency (150 μM) at the frog neuromuscular junction through a mechanism that is independent of intraterminal calcium. LY294002 causes the release of MEPPs through a perturbation of synaptotagmin function.LY294002 is also a BET inhibitor.".
- LY294002 iupacName "2-Morpholin-4-yl-8-phenylchromen-4-one".
- LY294002 thumbnail Ly294002.png?width=300.
- LY294002 wikiPageID "16620488".
- LY294002 wikiPageLength "5365".
- LY294002 wikiPageOutDegree "14".
- LY294002 wikiPageRevisionID "678942678".
- LY294002 wikiPageWikiLink BET_inhibitor.
- LY294002 wikiPageWikiLink Category:Chromones.
- LY294002 wikiPageWikiLink Category:Morpholines.
- LY294002 wikiPageWikiLink Category:Phosphoinositide_3-kinase_inhibitors.
- LY294002 wikiPageWikiLink End-plate_potential.
- LY294002 wikiPageWikiLink Hepatitis_C_virus.
- LY294002 wikiPageWikiLink IC50.
- LY294002 wikiPageWikiLink MEPP.
- LY294002 wikiPageWikiLink Morpholine.
- LY294002 wikiPageWikiLink PI3_kinase_inhibitor.
- LY294002 wikiPageWikiLink PIM1.
- LY294002 wikiPageWikiLink Phosphatidylinositol-4,5-bisphosphate_3-kinase.
- LY294002 wikiPageWikiLink Phosphoinositide_3-kinase.
- LY294002 wikiPageWikiLink Phosphoinositide_3-kinase_inhibitor.
- LY294002 wikiPageWikiLink Quercetin.
- LY294002 wikiPageWikiLink Wortmannin.
- LY294002 wikiPageWikiLinkText "LY294002".
- LY294002 hasPhotoCollection LY294002.
- LY294002 imagefile "Ly294002.png".
- LY294002 iupacname "2".
- LY294002 othernames "2".
- LY294002 verifiedfields "changed".
- LY294002 verifiedrevid "443344935".
- LY294002 watchedfields "changed".
- LY294002 wikiPageUsesTemplate Template:Biochemistry-stub.
- LY294002 wikiPageUsesTemplate Template:Chembox.
- LY294002 subject Category:Chromones.
- LY294002 subject Category:Morpholines.
- LY294002 subject Category:Phosphoinositide_3-kinase_inhibitors.
- LY294002 hypernym Compound.
- LY294002 type Article.
- LY294002 type ChemicalCompound.
- LY294002 type ChemicalSubstance.
- LY294002 type Article.
- LY294002 type Chemical.
- LY294002 type Chromene.
- LY294002 type Ether.
- LY294002 type Heterocycle.
- LY294002 type Inhibitor.
- LY294002 type Ketone.
- LY294002 type ChemicalObject.
- LY294002 type Thing.
- LY294002 type Q11173.
- LY294002 comment "LY294002 is a morpholine-containing chemical compound that is a potent inhibitor of numerous proteins, and a strong inhibitor of phosphoinositide 3-kinases (PI3Ks). It is generally considered a non-selective research tool, and should not be used for experiments aiming to target PI3K uniquely. Two of these are the proto-oncogene serine/threonine-protein kinase (PIM1) and the phosphatidylinositol-4,5-bisphosphate 3-kinase P110 gamma|catalytic subunit gamma isoform.".
- LY294002 label "LY294002".
- LY294002 sameAs الوای۲۹۴۰۰۲.
- LY294002 sameAs m.03yfg60.
- LY294002 sameAs LY294002.
- LY294002 sameAs LY294002.
- LY294002 sameAs LY294002.
- LY294002 sameAs Q4042503.
- LY294002 sameAs Q4042503.
- LY294002 wasDerivedFrom LY294002?oldid=678942678.
- LY294002 depiction Ly294002.png.
- LY294002 isPrimaryTopicOf LY294002.