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- LY-341,495 abstract "LY-341,495 is a research drug developed by the pharmaceutical company Eli Lilly, which acts as a potent and selective orthosteric antagonist for the group II metabotropic glutamate receptors (mGluR2/3).It is used in scientific research in several different areas, showing antidepressant effects in animal models, increasing the behavioural effects of hallucinogenic drugs in animal tests, and increasing the analgesic effects of μ-opioid agonists, as well as modulating dopamine receptor function.The 1-fluorocyclopropane analog has a superior pharmacokinetic profile and similar mGluR2/3 affinity, and making a prodrug from this with the heptyl ester increases bioavailability still further.".
- LY-341,495 casNumber "201943-63-7".
- LY-341,495 iupacName "2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-(D)-alanine".
- LY-341,495 thumbnail LY-341,495.svg?width=300.
- LY-341,495 wikiPageID "17070978".
- LY-341,495 wikiPageLength "8329".
- LY-341,495 wikiPageOutDegree "14".
- LY-341,495 wikiPageRevisionID "678942658".
- LY-341,495 wikiPageWikiLink Agonist.
- LY-341,495 wikiPageWikiLink Analgesic.
- LY-341,495 wikiPageWikiLink Antidepressant.
- LY-341,495 wikiPageWikiLink CECXG.
- LY-341,495 wikiPageWikiLink Category:Eli_Lilly_and_Company.
- LY-341,495 wikiPageWikiLink Category:MGlu2_receptor_antagonists.
- LY-341,495 wikiPageWikiLink Category:MGlu3_receptor_antagonists.
- LY-341,495 wikiPageWikiLink Dopamine_receptor.
- LY-341,495 wikiPageWikiLink Eli_Lilly_and_Company.
- LY-341,495 wikiPageWikiLink Metabotropic_glutamate_receptor.
- LY-341,495 wikiPageWikiLink Mu_opioid_receptor.
- LY-341,495 wikiPageWikiLink Pharmacokinetic.
- LY-341,495 wikiPageWikiLink Pharmacokinetics.
- LY-341,495 wikiPageWikiLink Prodrug.
- LY-341,495 wikiPageWikiLink Μ-opioid_receptor.
- LY-341,495 wikiPageWikiLink File:LY-341,495_prodrug.svg.
- LY-341,495 wikiPageWikiLinkText "LY-341,495".
- LY-341,495 c "20".
- LY-341,495 casNumber "201943".
- LY-341,495 chemspiderid "7995676".
- LY-341,495 h "19".
- LY-341,495 hasPhotoCollection LY-341,495.
- LY-341,495 inchi "1".
- LY-341,495 inchikey "VLZBRVJVCCNPRJ-KPHUOKFYBL".
- LY-341,495 iupacName "2".
- LY-341,495 molecularWeight "353.37".
- LY-341,495 n "1".
- LY-341,495 o "5".
- LY-341,495 smiles "C1[C@@H]CO".
- LY-341,495 stdinchi "1".
- LY-341,495 stdinchikey "VLZBRVJVCCNPRJ-KPHUOKFYSA-N".
- LY-341,495 synonyms "(-2-Amino-2-[-2-carboxycycloprop-1-yl]-3-propanoic acid)".
- LY-341,495 verifiedfields "changed".
- LY-341,495 verifiedrevid "424772766".
- LY-341,495 watchedfields "changed".
- LY-341,495 width "200".
- LY-341,495 wikiPageUsesTemplate Template:Drugbox.
- LY-341,495 wikiPageUsesTemplate Template:Glutamatergics.
- LY-341,495 wikiPageUsesTemplate Template:Reflist.
- LY-341,495 subject Category:Eli_Lilly_and_Company.
- LY-341,495 subject Category:MGlu2_receptor_antagonists.
- LY-341,495 subject Category:MGlu3_receptor_antagonists.
- LY-341,495 hypernym Drug.
- LY-341,495 type ChemicalSubstance.
- LY-341,495 type Drug.
- LY-341,495 type ChemicalObject.
- LY-341,495 type Thing.
- LY-341,495 type Q8386.
- LY-341,495 comment "LY-341,495 is a research drug developed by the pharmaceutical company Eli Lilly, which acts as a potent and selective orthosteric antagonist for the group II metabotropic glutamate receptors (mGluR2/3).It is used in scientific research in several different areas, showing antidepressant effects in animal models, increasing the behavioural effects of hallucinogenic drugs in animal tests, and increasing the analgesic effects of μ-opioid agonists, as well as modulating dopamine receptor function.The 1-fluorocyclopropane analog has a superior pharmacokinetic profile and similar mGluR2/3 affinity, and making a prodrug from this with the heptyl ester increases bioavailability still further.".
- LY-341,495 label "LY-341,495".
- LY-341,495 sameAs m.0417cbw.
- LY-341,495 sameAs LY-341,495.
- LY-341,495 sameAs LY-341,495.
- LY-341,495 sameAs Q6460424.
- LY-341,495 sameAs Q6460424.
- LY-341,495 wasDerivedFrom LY-341,495?oldid=678942658.
- LY-341,495 depiction LY-341,495.svg.
- LY-341,495 isPrimaryTopicOf LY-341,495.