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- LNCaP abstract "LNCaP cells are a cell line of human cells commonly used in the field of oncology. LNCaP cells are androgen-sensitive human prostate adenocarcinoma cells derived from the left supraclavicular lymph node metastasis from a 50-year-old caucasian male in 1977. They are adherent epithelial cells growing in aggregates and as single cells.One major obstacle to the conducting the most clinically relevant prostate cancer (PCa) research has been the lack of cell lines that closely mimic human disease progression. Two hallmarks of metastatic human prostate cancer include the shift of aggressive PCa from androgen-sensitivity to an Androgen Insensitive (AI) state, and the propensity of PCa to metastasize to bone. Although the generation of AI cell lines has been quite successful as demonstrated in the “classic” cell lines DU145 and PC3, the behavior of these cells in bone does not fully mimic clinical human disease. It is well established that human PCa bone metastasis form osteoblastic lesions rather than osteolytic lesions seen in other cancers like breast cancer. Similarly, PC-3 and DU145 cells form osteolytic tumors. To develop an AI-PCa cell model that more closely mimics clinical disease, LNCaP sublines have been generated to provide the most clinically relevant tissue culture tools to date.".
- LNCaP thumbnail Comparison_of_cancer_cell_lines.png?width=300.
- LNCaP wikiPageExternalLink Cell-Lines_3599.html.
- LNCaP wikiPageID "2214623".
- LNCaP wikiPageLength "10779".
- LNCaP wikiPageOutDegree "39".
- LNCaP wikiPageRevisionID "627411500".
- LNCaP wikiPageWikiLink Adenocarcinoma.
- LNCaP wikiPageWikiLink Alkaline_phosphatase.
- LNCaP wikiPageWikiLink Androgen.
- LNCaP wikiPageWikiLink Androgen_receptor.
- LNCaP wikiPageWikiLink Ascorbic_acid.
- LNCaP wikiPageWikiLink BMP7.
- LNCaP wikiPageWikiLink Bone_metastasis.
- LNCaP wikiPageWikiLink Bone_morphogenetic_protein_7.
- LNCaP wikiPageWikiLink Bone_sialoprotein.
- LNCaP wikiPageWikiLink Category:Cancer_research.
- LNCaP wikiPageWikiLink Category:Cell_lines.
- LNCaP wikiPageWikiLink Category:Prostate_cancer.
- LNCaP wikiPageWikiLink Cbfa1.
- LNCaP wikiPageWikiLink Cell_culture.
- LNCaP wikiPageWikiLink Cell_line.
- LNCaP wikiPageWikiLink Chromosome.
- LNCaP wikiPageWikiLink Cytokeratin_8.
- LNCaP wikiPageWikiLink DU145.
- LNCaP wikiPageWikiLink Dihydrotestosterone.
- LNCaP wikiPageWikiLink Estrogen.
- LNCaP wikiPageWikiLink Hormone.
- LNCaP wikiPageWikiLink Hydroxyapatite.
- LNCaP wikiPageWikiLink Hydroxylapatite.
- LNCaP wikiPageWikiLink Interferon.
- LNCaP wikiPageWikiLink Karyotype.
- LNCaP wikiPageWikiLink Keratin_8.
- LNCaP wikiPageWikiLink Metastasis.
- LNCaP wikiPageWikiLink Oncology.
- LNCaP wikiPageWikiLink Ornithine_decarboxylase.
- LNCaP wikiPageWikiLink Osteoblast.
- LNCaP wikiPageWikiLink Osteoblasts.
- LNCaP wikiPageWikiLink Osteocalcin.
- LNCaP wikiPageWikiLink Osteonectin.
- LNCaP wikiPageWikiLink Osteoprotegerin.
- LNCaP wikiPageWikiLink PC3.
- LNCaP wikiPageWikiLink Prostate.
- LNCaP wikiPageWikiLink Prostate-specific_antigen.
- LNCaP wikiPageWikiLink Prostate_Specific_Antigen.
- LNCaP wikiPageWikiLink Prostate_cancer.
- LNCaP wikiPageWikiLink RANKL.
- LNCaP wikiPageWikiLink RUNX2.
- LNCaP wikiPageWikiLink Y_chromosome.
- LNCaP wikiPageWikiLink File:Comparison_of_cancer_cell_lines.png.
- LNCaP wikiPageWikiLinkText "LNCaP".
- LNCaP wikiPageWikiLinkText "LNCap".
- LNCaP wikiPageWikiLinkText "Lncap".
- LNCaP hasPhotoCollection LNCaP.
- LNCaP wikiPageUsesTemplate Template:Cite_journal.
- LNCaP wikiPageUsesTemplate Template:Refbegin.
- LNCaP wikiPageUsesTemplate Template:Refend.
- LNCaP wikiPageUsesTemplate Template:Refimprove.
- LNCaP wikiPageUsesTemplate Template:Reflist.
- LNCaP subject Category:Cancer_research.
- LNCaP subject Category:Cell_lines.
- LNCaP subject Category:Prostate_cancer.
- LNCaP hypernym Line.
- LNCaP type Article.
- LNCaP type Article.
- LNCaP type Line.
- LNCaP comment "LNCaP cells are a cell line of human cells commonly used in the field of oncology. LNCaP cells are androgen-sensitive human prostate adenocarcinoma cells derived from the left supraclavicular lymph node metastasis from a 50-year-old caucasian male in 1977.".
- LNCaP label "LNCaP".
- LNCaP sameAs m.06whvb.
- LNCaP sameAs Q6459234.
- LNCaP sameAs Q6459234.
- LNCaP wasDerivedFrom LNCaP?oldid=627411500.
- LNCaP depiction Comparison_of_cancer_cell_lines.png.
- LNCaP isPrimaryTopicOf LNCaP.