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- LCCL_domain abstract "In molecular biology, the LCCL domain is a protein domain which has been named after several well-characterised proteins that were found to contain it, namely Limulus clotting factor C, Coch-5b2 (Cochlin) and Lgl1. It is an about 100 amino acids domain whose C-terminal part contains a highly conserved histidine in a conserved motif YxxxSxxCxAAVHxGVI. The LCCL module is thought to be an autonomously folding domain that has been used for the construction of various modular proteins through exon-shuffling. It has been found in various metazoan proteins in association with complement B-type domains, C-type lectin domains, von Willebrand type A domains, CUB domains, discoidin lectin domains or CAP domains. It has been proposed that the LCCL domain could be involved in lipopolysaccharide (LPS) binding. Secondary structure prediction suggests that the LCCL domain contains six beta strands and two alpha helices.Some proteins known to contain a LCCL domain include Limulus factor C, an LPS endotoxin-sensitive trypsin type serine protease which serves to protect the organism from bacterial infection; vertebrate cochlear protein cochlin or coch-5b2 (Cochlin is probably a secreted protein, mutations affecting the LCCL domain of coch-5b2 cause the deafness disorder DFNA9 in humans); and mammalian late gestation lung protein Lgl1, contains two tandem copies of the LCCL domain.".
- LCCL_domain symbol "LCCL".
- LCCL_domain wikiPageID "34577796".
- LCCL_domain wikiPageLength "3173".
- LCCL_domain wikiPageOutDegree "36".
- LCCL_domain wikiPageRevisionID "592161662".
- LCCL_domain wikiPageWikiLink Alpha_helix.
- LCCL_domain wikiPageWikiLink Amino_acid.
- LCCL_domain wikiPageWikiLink Animal.
- LCCL_domain wikiPageWikiLink Autonomous.
- LCCL_domain wikiPageWikiLink Autonomy.
- LCCL_domain wikiPageWikiLink Bacteria.
- LCCL_domain wikiPageWikiLink Beta_sheet.
- LCCL_domain wikiPageWikiLink Beta_strand.
- LCCL_domain wikiPageWikiLink Binding_(molecular).
- LCCL_domain wikiPageWikiLink Biomolecular_structure.
- LCCL_domain wikiPageWikiLink C-terminal.
- LCCL_domain wikiPageWikiLink C-terminus.
- LCCL_domain wikiPageWikiLink C-type_lectin.
- LCCL_domain wikiPageWikiLink C-type_lectin_domain.
- LCCL_domain wikiPageWikiLink CAP_protein_family.
- LCCL_domain wikiPageWikiLink COCH.
- LCCL_domain wikiPageWikiLink CUB_domain.
- LCCL_domain wikiPageWikiLink Category:Protein_domains.
- LCCL_domain wikiPageWikiLink Cochlea.
- LCCL_domain wikiPageWikiLink Complement_B-type_domain.
- LCCL_domain wikiPageWikiLink Conserved_sequence.
- LCCL_domain wikiPageWikiLink Discoidin_lectin_domain.
- LCCL_domain wikiPageWikiLink Exon_shuffling.
- LCCL_domain wikiPageWikiLink Gestation.
- LCCL_domain wikiPageWikiLink Histidine.
- LCCL_domain wikiPageWikiLink Lipopolysaccharide.
- LCCL_domain wikiPageWikiLink Lung.
- LCCL_domain wikiPageWikiLink Mammal.
- LCCL_domain wikiPageWikiLink Mammalia.
- LCCL_domain wikiPageWikiLink Metazoan.
- LCCL_domain wikiPageWikiLink Molecular_binding.
- LCCL_domain wikiPageWikiLink Organism.
- LCCL_domain wikiPageWikiLink Protein.
- LCCL_domain wikiPageWikiLink Protein_domain.
- LCCL_domain wikiPageWikiLink Protein_folding.
- LCCL_domain wikiPageWikiLink Protein_motif.
- LCCL_domain wikiPageWikiLink Proteins.
- LCCL_domain wikiPageWikiLink Secondary_structure.
- LCCL_domain wikiPageWikiLink Secreted.
- LCCL_domain wikiPageWikiLink Secretion.
- LCCL_domain wikiPageWikiLink Serine_protease.
- LCCL_domain wikiPageWikiLink Structural_motif.
- LCCL_domain wikiPageWikiLink Trypsin.
- LCCL_domain wikiPageWikiLink Vertebrate.
- LCCL_domain wikiPageWikiLink Von_Willebrand_type_A_domain.
- LCCL_domain wikiPageWikiLinkText "LCCL domain".
- LCCL_domain hasPhotoCollection LCCL_domain.
- LCCL_domain interpro "IPR004043".
- LCCL_domain name "LCCL".
- LCCL_domain pfam "PF03815".
- LCCL_domain pfamClan "CL0513".
- LCCL_domain scop "1".
- LCCL_domain symbol "LCCL".
- LCCL_domain wikiPageUsesTemplate Template:Infobox_protein_family.
- LCCL_domain wikiPageUsesTemplate Template:InterPro_content.
- LCCL_domain wikiPageUsesTemplate Template:Reflist.
- LCCL_domain subject Category:Protein_domains.
- LCCL_domain hypernym Domain.
- LCCL_domain type Biomolecule.
- LCCL_domain type Protein.
- LCCL_domain type Domain.
- LCCL_domain type Thing.
- LCCL_domain type Q206229.
- LCCL_domain type Q8054.
- LCCL_domain comment "In molecular biology, the LCCL domain is a protein domain which has been named after several well-characterised proteins that were found to contain it, namely Limulus clotting factor C, Coch-5b2 (Cochlin) and Lgl1. It is an about 100 amino acids domain whose C-terminal part contains a highly conserved histidine in a conserved motif YxxxSxxCxAAVHxGVI.".
- LCCL_domain label "LCCL domain".
- LCCL_domain sameAs m.0j29zjw.
- LCCL_domain sameAs Q6457369.
- LCCL_domain sameAs Q6457369.
- LCCL_domain wasDerivedFrom LCCL_domain?oldid=592161662.
- LCCL_domain isPrimaryTopicOf LCCL_domain.