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- L27_domain abstract "The L27 domain is a protein domain that is found in receptor targeting proteins Lin-2 and Lin-7 (LIN7A, LIN7B, LIN7C), as well as some protein kinases and human MPP2 protein. The L27 domain is a protein interaction module that exists in a large family of scaffold proteins, functioning as an organisation centre of large protein assemblies required for the establishment and maintenance of cell polarity. L27 domains form specific heterotetrameric complexes, in which each domain contains three alpha-helices.The L27_2 domain is a protein-protein interaction domain capable of organising scaffold proteins into supramolecular assemblies by formation of heteromeric L27_2 domain complexes. L27_2 domain-mediated protein assemblies have been shown to play essential roles in cellular processes including asymmetric cell division, establishment and maintenance of cell polarity, and clustering of receptors and ion channels. Members of this family form specific heterotetrameric complexes, in which each domain contains three alpha-helices. The two N-terminal helices of each L27_2 domain pack together to form a tight, four-helix bundle in the heterodimer, whilst the third helix of each L27_2 domain forms another four-helix bundle that assembles the two units of the heterodimer into a tetramer.The L27_N domain is often found at the N-terminus of the L27 domain. It plays a role in the biogenesis of tight junctions and in the establishment of cell polarity in epithelial cells. Each L27_N domain consists of three alpha-helices, the first two of which form an antiparallel coiled-coil. Two L27 domains come together to form a four-helical bundle with the antiparallel coiled-coils formed by the first two helices. The third helix of each domain forms another coiled-coil packing at one end of the four-helix bundle, creating a large hydrophobic interface: the hydrophobic interactions are the major force that drives heterodimer formation.".
- L27_domain symbol "L27".
- L27_domain symbol "L27_1".
- L27_domain symbol "L27_2".
- L27_domain symbol "L27_N".
- L27_domain thumbnail PDB_1rso_EBI.jpg?width=300.
- L27_domain wikiPageID "26054779".
- L27_domain wikiPageLength "6265".
- L27_domain wikiPageOutDegree "41".
- L27_domain wikiPageRevisionID "606731902".
- L27_domain wikiPageWikiLink Alpha_helix.
- L27_domain wikiPageWikiLink Antiparallel_(biochemistry).
- L27_domain wikiPageWikiLink Asymmetry.
- L27_domain wikiPageWikiLink Biogenesis.
- L27_domain wikiPageWikiLink CASK.
- L27_domain wikiPageWikiLink Category:Protein_domains.
- L27_domain wikiPageWikiLink Category:Protein_structure.
- L27_domain wikiPageWikiLink Cell_(biology).
- L27_domain wikiPageWikiLink Cell_division.
- L27_domain wikiPageWikiLink Cell_polarity.
- L27_domain wikiPageWikiLink Coiled_coil.
- L27_domain wikiPageWikiLink Epithelial_cell.
- L27_domain wikiPageWikiLink Epithelium.
- L27_domain wikiPageWikiLink Helix.
- L27_domain wikiPageWikiLink Heterodimer.
- L27_domain wikiPageWikiLink Heteromer.
- L27_domain wikiPageWikiLink Heteromeric.
- L27_domain wikiPageWikiLink Heterotetramer.
- L27_domain wikiPageWikiLink Heterotetrameric.
- L27_domain wikiPageWikiLink Hydrophobe.
- L27_domain wikiPageWikiLink Hydrophobic.
- L27_domain wikiPageWikiLink Ion_channel.
- L27_domain wikiPageWikiLink Ion_channels.
- L27_domain wikiPageWikiLink LIN7A.
- L27_domain wikiPageWikiLink LIN7B.
- L27_domain wikiPageWikiLink LIN7C.
- L27_domain wikiPageWikiLink List_of_protein_interactions.
- L27_domain wikiPageWikiLink MPP2.
- L27_domain wikiPageWikiLink N-terminal.
- L27_domain wikiPageWikiLink N-terminus.
- L27_domain wikiPageWikiLink Protein.
- L27_domain wikiPageWikiLink Protein-protein_interaction.
- L27_domain wikiPageWikiLink Protein_dimer.
- L27_domain wikiPageWikiLink Protein_domain.
- L27_domain wikiPageWikiLink Protein_interaction.
- L27_domain wikiPageWikiLink Protein_kinase.
- L27_domain wikiPageWikiLink Protein–protein_interaction.
- L27_domain wikiPageWikiLink Receptor_(biochemistry).
- L27_domain wikiPageWikiLink Scaffold_protein.
- L27_domain wikiPageWikiLink Tetramer.
- L27_domain wikiPageWikiLink Tight_junction.
- L27_domain wikiPageWikiLinkText "L27 domain".
- L27_domain wikiPageWikiLinkText "L27".
- L27_domain caption "2.1".
- L27_domain caption "Structure of presynaptic protein SAP97.".
- L27_domain caption "hetero-tetrameric l27 domain complexes as organization platforms of supra-molecular assemblies".
- L27_domain hasPhotoCollection L27_domain.
- L27_domain interpro "IPR014775".
- L27_domain interpro "IPR015132".
- L27_domain interpro "IPR015143".
- L27_domain interpro "IPR015145".
- L27_domain name "L27 domain".
- L27_domain name "L27_1".
- L27_domain name "L27_2".
- L27_domain name "L27_N".
- L27_domain pdb ", , ,".
- L27_domain pfam "PF02828".
- L27_domain pfam "PF09045".
- L27_domain pfam "PF09058".
- L27_domain pfam "PF09060".
- L27_domain symbol "L27".
- L27_domain symbol "L27_1".
- L27_domain symbol "L27_2".
- L27_domain symbol "L27_N".
- L27_domain wikiPageUsesTemplate Template:Cite_journal.
- L27_domain wikiPageUsesTemplate Template:Infobox_protein_family.
- L27_domain wikiPageUsesTemplate Template:InterPro_content.
- L27_domain wikiPageUsesTemplate Template:Protein-stub.
- L27_domain wikiPageUsesTemplate Template:Refbegin.
- L27_domain wikiPageUsesTemplate Template:Refend.
- L27_domain wikiPageUsesTemplate Template:Reflist.
- L27_domain subject Category:Protein_domains.
- L27_domain subject Category:Protein_structure.
- L27_domain hypernym Domain.
- L27_domain type Biomolecule.
- L27_domain type Protein.
- L27_domain type Biophysic.
- L27_domain type Chemical.
- L27_domain type Domain.
- L27_domain type Thing.
- L27_domain type Q206229.
- L27_domain type Q8054.
- L27_domain comment "The L27 domain is a protein domain that is found in receptor targeting proteins Lin-2 and Lin-7 (LIN7A, LIN7B, LIN7C), as well as some protein kinases and human MPP2 protein. The L27 domain is a protein interaction module that exists in a large family of scaffold proteins, functioning as an organisation centre of large protein assemblies required for the establishment and maintenance of cell polarity.".
- L27_domain label "L27 domain".
- L27_domain sameAs m.0b6lg28.
- L27_domain sameAs Q6456851.
- L27_domain sameAs Q6456851.
- L27_domain wasDerivedFrom L27_domain?oldid=606731902.
- L27_domain depiction PDB_1rso_EBI.jpg.
- L27_domain isPrimaryTopicOf L27_domain.