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- L1_family abstract "The L1 family is a family of cell adhesion molecules that includes four different L1-like proteins. They are members of the immunoglobulin superfamily (IgSF CAM). The members of the L1-family in humans are called L1 or L1cam, CHL1 (close homologue of L1), Neurofascin and NrCAM (NgCAM related cell adhesion molecule). L1 family members are found on neurons, especially on their axons. Sometimes they are found on glia, such as Schwann cells, radial glia and Bergmann glia cells and, as such, are important for neural cell migration during development. L1 family members are expressed throughout the vertebrate and invertebrate kingdoms. L1 family members are able to bind to a number of other proteins. As cell adhesion molecules, they often bind "homophilically" to themselves; for example L1 on one cell binding to L1 on an adjacent cell. L1 family members also bind "heterophilically" to members of the contactin or CNTN1 family. L1 family members bind to many cytoplasmic proteins such as Ankyrins, ezrin-moesin-radixin (ERM) proteins, signaling molecules like src (src gene) and erk (Extracellular signal-regulated kinases) and proteins important in trafficking, such as AP-2.NrCAM and neurofascin both have class 1 PDZ domain binding motifs at their COOH termini. NrCAM can bind to SAP102 and other members of the MAGUK family.Roles in the body:"The importance of L1 in neural development has been revealed in several ways. In humans, mutations in the L1 gene can have devastating consequences. In extreme cases, babies are born with a fatal condition of hydrocephalus ("water on the brain"). Children with less severe mutations typically exhibit mental retardation and difficulty in controlling limb movements (spasticity). Autopsies on patients that have died of an L1-deficiency disease reveal a remarkable condition: they are often missing two large nerve tracts, one that runs in the two halves of the brain and the other that runs between the brain and the spinal cord. The absence of such nerve tracts suggests that L1 is involved in the growth of axons within the embryonic nervous system."**".
- L1_family wikiPageExternalLink cell9.html.
- L1_family wikiPageID "1648179".
- L1_family wikiPageLength "2497".
- L1_family wikiPageOutDegree "18".
- L1_family wikiPageRevisionID "584352579".
- L1_family wikiPageWikiLink Ankyrin.
- L1_family wikiPageWikiLink Astrocyte.
- L1_family wikiPageWikiLink Bergmann_glia.
- L1_family wikiPageWikiLink CHL1.
- L1_family wikiPageWikiLink CNTN1.
- L1_family wikiPageWikiLink Category:Cell_adhesion_proteins.
- L1_family wikiPageWikiLink Category:Nervous_system.
- L1_family wikiPageWikiLink Cell_adhesion_molecule.
- L1_family wikiPageWikiLink Extracellular_signal-regulated_kinases.
- L1_family wikiPageWikiLink Hydrocephalus.
- L1_family wikiPageWikiLink IgSF_CAM.
- L1_family wikiPageWikiLink L1_(protein).
- L1_family wikiPageWikiLink L1_family.
- L1_family wikiPageWikiLink MAGUK_family.
- L1_family wikiPageWikiLink Neurofascin.
- L1_family wikiPageWikiLink NrCAM.
- L1_family wikiPageWikiLink Radial_glia.
- L1_family wikiPageWikiLink Radial_glial_cell.
- L1_family wikiPageWikiLink SAP102.
- L1_family wikiPageWikiLink Src_gene.
- L1_family wikiPageWikiLink Tyrosine-protein_kinase_CSK.
- L1_family wikiPageWikiLinkText "L1 family".
- L1_family wikiPageWikiLinkText "L1 protein family".
- L1_family wikiPageWikiLinkText "proteins".
- L1_family hasPhotoCollection L1_family.
- L1_family wikiPageUsesTemplate Template:Protein-stub.
- L1_family subject Category:Cell_adhesion_proteins.
- L1_family subject Category:Nervous_system.
- L1_family hypernym Family.
- L1_family comment "The L1 family is a family of cell adhesion molecules that includes four different L1-like proteins. They are members of the immunoglobulin superfamily (IgSF CAM). The members of the L1-family in humans are called L1 or L1cam, CHL1 (close homologue of L1), Neurofascin and NrCAM (NgCAM related cell adhesion molecule). L1 family members are found on neurons, especially on their axons.".
- L1_family label "L1 family".
- L1_family sameAs m.05kgbd.
- L1_family sameAs Q6456840.
- L1_family sameAs Q6456840.
- L1_family wasDerivedFrom L1_family?oldid=584352579.
- L1_family isPrimaryTopicOf L1_family.