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- L-type_calcium_channel abstract "The L-type calcium channel (also known as the dihydropyridine channel, or DHP channel) is part of the high-voltage activated family of voltage-dependent calcium channel. "L" stands for long-lasting referring to the length of activation. This channel has four subunits (Cav1.1, Cav1.2, Cav1.3, Cav1.4).L-type calcium channels are responsible for excitation-contraction coupling of skeletal, smooth, cardiac muscle and for aldosterone secretion in endocrine cells of the adrenal cortex.In cardiac myocytes, the L-type calcium channel passes inward Ca2+ current and triggers calcium release from the sarcoplasmic reticulum by activating Ryanodine receptor 2 (RyR2) (calcium-induced-calcium-release). Phosphorylation of these channels increases their permeability to calcium and increases the contractility of their respective cardiac myocytes.L-type calcium channel blocker drugs are used as cardiac antiarrhythmics or antihypertensives, depending on whether the drugs have higher affinity for the heart (the phenylalkylamines, like verapamil), or for the vessels (the dihydropyridines, like nifedipine).In skeletal muscle, there is a very high concentration of L-type calcium channels, situated inthe T-tubules. Muscle depolarization results in large gatingcurrents, but anomalously low calcium flux, which is nowexplained by the very slow activation of the ionic currents. Forthis reason, little or no Ca2+ passes across the T-tubulemembrane during a single action potential.".
- L-type_calcium_channel symbol "Calcium channel, voltage-dependent".
- L-type_calcium_channel thumbnail Protein_CACNA1D_PDB_2be6.png?width=300.
- L-type_calcium_channel wikiPageExternalLink FamilyMenuForward?familyId=11.
- L-type_calcium_channel wikiPageID "9773358".
- L-type_calcium_channel wikiPageLength "4837".
- L-type_calcium_channel wikiPageOutDegree "33".
- L-type_calcium_channel wikiPageRevisionID "654900341".
- L-type_calcium_channel wikiPageWikiLink Adrenal_cortex.
- L-type_calcium_channel wikiPageWikiLink Aldosterone.
- L-type_calcium_channel wikiPageWikiLink Antiarrhythmic_agent.
- L-type_calcium_channel wikiPageWikiLink Antiarrhythmics.
- L-type_calcium_channel wikiPageWikiLink Antihypertensive_drug.
- L-type_calcium_channel wikiPageWikiLink Antihypertensives.
- L-type_calcium_channel wikiPageWikiLink Arylalkylamine.
- L-type_calcium_channel wikiPageWikiLink CACNA1C.
- L-type_calcium_channel wikiPageWikiLink CACNA1D.
- L-type_calcium_channel wikiPageWikiLink CACNA1F.
- L-type_calcium_channel wikiPageWikiLink CACNA1S.
- L-type_calcium_channel wikiPageWikiLink Calcium_channel_blocker.
- L-type_calcium_channel wikiPageWikiLink Cardiac_muscle.
- L-type_calcium_channel wikiPageWikiLink Category:Electrophysiology.
- L-type_calcium_channel wikiPageWikiLink Category:Integral_membrane_proteins.
- L-type_calcium_channel wikiPageWikiLink Category:Ion_channels.
- L-type_calcium_channel wikiPageWikiLink Category:Membrane_biology.
- L-type_calcium_channel wikiPageWikiLink Cav1.1.
- L-type_calcium_channel wikiPageWikiLink Cav1.2.
- L-type_calcium_channel wikiPageWikiLink Cav1.3.
- L-type_calcium_channel wikiPageWikiLink Cav1.4.
- L-type_calcium_channel wikiPageWikiLink DHP_receptor.
- L-type_calcium_channel wikiPageWikiLink Dihydropyridine.
- L-type_calcium_channel wikiPageWikiLink Dihydropyridines.
- L-type_calcium_channel wikiPageWikiLink Endocrine_gland.
- L-type_calcium_channel wikiPageWikiLink Endocrine_glands.
- L-type_calcium_channel wikiPageWikiLink Heart.
- L-type_calcium_channel wikiPageWikiLink Muscle_contraction.
- L-type_calcium_channel wikiPageWikiLink Nifedipine.
- L-type_calcium_channel wikiPageWikiLink Phenylalkylamines.
- L-type_calcium_channel wikiPageWikiLink Ryanodine_receptor_2.
- L-type_calcium_channel wikiPageWikiLink Skeletal_muscle.
- L-type_calcium_channel wikiPageWikiLink Smooth_muscle.
- L-type_calcium_channel wikiPageWikiLink Smooth_muscle_tissue.
- L-type_calcium_channel wikiPageWikiLink T-tubule.
- L-type_calcium_channel wikiPageWikiLink T-tubules.
- L-type_calcium_channel wikiPageWikiLink Verapamil.
- L-type_calcium_channel wikiPageWikiLink Voltage-dependent_calcium_channel.
- L-type_calcium_channel wikiPageWikiLink File:Alphasubunit_sodium_channel.png.
- L-type_calcium_channel wikiPageWikiLink File:L-type_D-subtype_CaV1.3_calcium_channel_CACNA1D_in_human_adrenal_zona_glomerulosa.jpg.
- L-type_calcium_channel wikiPageWikiLinkText "L type".
- L-type_calcium_channel wikiPageWikiLinkText "L-type calcium channel".
- L-type_calcium_channel wikiPageWikiLinkText "L-type".
- L-type_calcium_channel caption "Crystallographic structure".
- L-type_calcium_channel hasPhotoCollection L-type_calcium_channel.
- L-type_calcium_channel name "Calcium channel, voltage-dependent".
- L-type_calcium_channel symbol "Calcium channel, voltage-dependent".
- L-type_calcium_channel width "300".
- L-type_calcium_channel wikiPageUsesTemplate Template:Cite_web.
- L-type_calcium_channel wikiPageUsesTemplate Template:Gene.
- L-type_calcium_channel wikiPageUsesTemplate Template:Ion_channels.
- L-type_calcium_channel wikiPageUsesTemplate Template:MeshName.
- L-type_calcium_channel wikiPageUsesTemplate Template:Pfam_box.
- L-type_calcium_channel wikiPageUsesTemplate Template:Reflist.
- L-type_calcium_channel wikiPageUsesTemplate Template:See_also.
- L-type_calcium_channel subject Category:Electrophysiology.
- L-type_calcium_channel subject Category:Integral_membrane_proteins.
- L-type_calcium_channel subject Category:Ion_channels.
- L-type_calcium_channel subject Category:Membrane_biology.
- L-type_calcium_channel hypernym Part.
- L-type_calcium_channel type Biomolecule.
- L-type_calcium_channel type Protein.
- L-type_calcium_channel type Biophysic.
- L-type_calcium_channel type Channel.
- L-type_calcium_channel type Thing.
- L-type_calcium_channel type Q206229.
- L-type_calcium_channel type Q8054.
- L-type_calcium_channel comment "The L-type calcium channel (also known as the dihydropyridine channel, or DHP channel) is part of the high-voltage activated family of voltage-dependent calcium channel. "L" stands for long-lasting referring to the length of activation.".
- L-type_calcium_channel label "L-type calcium channel".
- L-type_calcium_channel seeAlso Cardiac_action_potential.
- L-type_calcium_channel sameAs L-type-calciumkanaal.
- L-type_calcium_channel sameAs Canal_de_cálcio_do_tipo_L.
- L-type_calcium_channel sameAs m.02prs9r.
- L-type_calcium_channel sameAs Kalcijumski_kanal_L-tipa.
- L-type_calcium_channel sameAs Kalcijumski_kanal_L-tipa.
- L-type_calcium_channel sameAs Q2600696.
- L-type_calcium_channel sameAs Q2600696.
- L-type_calcium_channel sameAs L型钙通道.
- L-type_calcium_channel wasDerivedFrom L-type_calcium_channel?oldid=654900341.
- L-type_calcium_channel depiction Protein_CACNA1D_PDB_2be6.png.
- L-type_calcium_channel isPrimaryTopicOf L-type_calcium_channel.