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- L-838,417 abstract "L-838,417 is an anxiolytic drug used in scientific research. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. The compound was developed by Merck, Sharp and Dohme.L-838,417 is a subtype-selective GABAA positive allosteric modulator, acting as a partial agonist at α2, α3 and α5 subtypes. However, it acts as a negative allosteric modulator at the α1 subtype, and has little affinity for the α4 or α6 subtypes. This gives it selective anxiolytic effects, which are mediated mainly by α2 and α3 subtypes, but with little sedative or amnestic effects as these effects are mediated by α1. Some sedation might still be expected due to its activity at the α5 subtype, which can also cause sedation, however no sedative effects were seen in animal studies even at high doses, suggesting that L-838,417 is primarily acting at α2 and α3 subtypes with the α5 subtype of lesser importance.As might be predicted from its binding profile, L-838,417 substitutes for the anxiolytic benzodiazepine chlordiazepoxide in animals, but not for the hypnotic imidazopyridine drug zolpidem.The synthesis of L-838,417 and similar compounds was described in 2005 in the Journal of Medicinal Chemistry.".
- L-838,417 casNumber "286456-42-6".
- L-838,417 iupacName "3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-".
- L-838,417 pubchem "9908880".
- L-838,417 thumbnail L-838,417.svg?width=300.
- L-838,417 wikiPageID "14568730".
- L-838,417 wikiPageLength "7191".
- L-838,417 wikiPageOutDegree "30".
- L-838,417 wikiPageRevisionID "678940250".
- L-838,417 wikiPageWikiLink Allosteric_modulator.
- L-838,417 wikiPageWikiLink Amnesia.
- L-838,417 wikiPageWikiLink Amnestic.
- L-838,417 wikiPageWikiLink Anxiolytic.
- L-838,417 wikiPageWikiLink Benzodiazepine.
- L-838,417 wikiPageWikiLink Category:Anxiolytics.
- L-838,417 wikiPageWikiLink Category:Ethers.
- L-838,417 wikiPageWikiLink Category:GABAA_receptor_positive_allosteric_modulators.
- L-838,417 wikiPageWikiLink Category:Organofluorides.
- L-838,417 wikiPageWikiLink Category:Triazoles.
- L-838,417 wikiPageWikiLink Category:Triazolopyridazines.
- L-838,417 wikiPageWikiLink Chlordiazepoxide.
- L-838,417 wikiPageWikiLink GABAA_receptor.
- L-838,417 wikiPageWikiLink GABA_A_receptor.
- L-838,417 wikiPageWikiLink GABRA1.
- L-838,417 wikiPageWikiLink GABRA2.
- L-838,417 wikiPageWikiLink GABRA3.
- L-838,417 wikiPageWikiLink GABRA4.
- L-838,417 wikiPageWikiLink GABRA5.
- L-838,417 wikiPageWikiLink GABRA6.
- L-838,417 wikiPageWikiLink Gamma-aminobutyric_acid_receptor_subunit_alpha-1.
- L-838,417 wikiPageWikiLink Hypnotic.
- L-838,417 wikiPageWikiLink Imidazopyridine.
- L-838,417 wikiPageWikiLink Journal_of_Medicinal_Chemistry.
- L-838,417 wikiPageWikiLink Merck_&_Co..
- L-838,417 wikiPageWikiLink Merck_Sharp_and_Dohme.
- L-838,417 wikiPageWikiLink Negative_allosteric_modulator.
- L-838,417 wikiPageWikiLink Nonbenzodiazepine.
- L-838,417 wikiPageWikiLink Partial_agonist.
- L-838,417 wikiPageWikiLink Positive_allosteric_modulator.
- L-838,417 wikiPageWikiLink SL-651,498.
- L-838,417 wikiPageWikiLink Sedative.
- L-838,417 wikiPageWikiLink Zolpidem.
- L-838,417 wikiPageWikiLink Α5IA.
- L-838,417 wikiPageWikiLinkText "L-838,417".
- L-838,417 alt "Ball-and-stick model of the L-838,417 molecule".
- L-838,417 c "19".
- L-838,417 casNumber "286456".
- L-838,417 chembl "373250".
- L-838,417 chemspiderid "8084532".
- L-838,417 f "2".
- L-838,417 h "19".
- L-838,417 hasPhotoCollection L-838,417.
- L-838,417 image "L-838,417 3D ball.png".
- L-838,417 iupacName "3".
- L-838,417 iupharLigand "4241".
- L-838,417 molecularWeight "399.397".
- L-838,417 n "7".
- L-838,417 o "1".
- L-838,417 pubchem "9908880".
- L-838,417 smiles "CN1N=CN=C1COC4=NN2C=NN=C2C3=CC=CC=C3F".
- L-838,417 stdinchi "1".
- L-838,417 stdinchikey "BQDUNOMMYOKHEP-UHFFFAOYSA-N".
- L-838,417 verifiedfields "changed".
- L-838,417 verifiedrevid "461942177".
- L-838,417 width "250".
- L-838,417 wikiPageUsesTemplate Template:Anxiolytics.
- L-838,417 wikiPageUsesTemplate Template:Drugbox.
- L-838,417 wikiPageUsesTemplate Template:GABAAR_PAMs.
- L-838,417 subject Category:Anxiolytics.
- L-838,417 subject Category:Ethers.
- L-838,417 subject Category:GABAA_receptor_positive_allosteric_modulators.
- L-838,417 subject Category:Organofluorides.
- L-838,417 subject Category:Triazoles.
- L-838,417 subject Category:Triazolopyridazines.
- L-838,417 hypernym Drug.
- L-838,417 type ChemicalSubstance.
- L-838,417 type Drug.
- L-838,417 type ChemicalObject.
- L-838,417 type Thing.
- L-838,417 type Q8386.
- L-838,417 comment "L-838,417 is an anxiolytic drug used in scientific research. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. The compound was developed by Merck, Sharp and Dohme.L-838,417 is a subtype-selective GABAA positive allosteric modulator, acting as a partial agonist at α2, α3 and α5 subtypes. However, it acts as a negative allosteric modulator at the α1 subtype, and has little affinity for the α4 or α6 subtypes.".
- L-838,417 label "L-838,417".
- L-838,417 sameAs m.03d8567.
- L-838,417 sameAs L-838,417.
- L-838,417 sameAs L-838,417.
- L-838,417 sameAs Q6456086.
- L-838,417 sameAs Q6456086.
- L-838,417 wasDerivedFrom L-838,417?oldid=678940250.
- L-838,417 depiction L-838,417.svg.
- L-838,417 isPrimaryTopicOf L-838,417.