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- Koala_retrovirus abstract "Koala retrovirus (KoRV) is a retrovirus that is present in many populations of koalas. It has been implicated as the agent of Koala Immune Deficiency Syndrome (KIDS), an AIDS-like immunodeficiency that leaves infected koalas more susceptible to infectious disease and cancers. The virus is thought to be a recently introduced exogenous virus that is also integrating into the koala genome (becoming endogenous). Thus the virus can transmit both horizontally (from animal to animal in the classic sense) and vertically (from parent to offspring as a gene). The horizontal modes of transmission are not well defined but are thought to require close contact.Koala retrovirus was initially described as a novel endogenous retrovirus found within the koala genome and in tissues as free virions. Viral DNA sequence analysis showed intact open reading frames and pathogenic DNA motifs strongly suggesting that KoRV is an active replicating endogenous virus that can also produce infectious virions. The analysis also showed that KoRV was closely related to the highly pathogenic Gibbon Ape Leukemia Virus (GALV). The epidemiology of how koalas and gibbons came to share such similar viruses remains unclear.The virus has been attributed to 80% of deaths in captive koalas in Queensland from leukaemia, lymphoma, malignant tumours and immune deficiency disorders. In 2008, lead researcher Jon Hanger, said the virus was a threat that could lead to extinction of koalas in Queensland within 15 years, claiming 100% infection rates in studied populations that suggest an epidemic.Research has also shown that some populations of koalas, particularly an isolated colony on Kangaroo Island do not appear to have the endogenous form of the retrovirus. This suggests that the virus gene sequence is a new acquisition for the koala genome. Prevalence of KoRV (and KIDS) in Australian koala populations suggests a trend spreading from the north down to the south of Australia. Northern populations are completely infected, while some southern populations (including Kangaroo Island) are free. Prior to this 'koala retrovirus' was used to refer to an unidentified oncovirus detected in cancer-affected koalas.In 2013, an exclusively exogenous subtype of KoRV was identified and termed KoRVB (with the endogenous form of KoRV referred to as KoRVA.) KoRVA utilizes the ubiquitous SLC20A1 as a viral receptor, whereas KoRVB infects via SLC19A2 which is found on a limited number of cell types and not at all on germ line cells. Therefore, KoRVB will remain exogenous and more pathogenic than KoRVA, because the deleterious effects it causes in its hosts will not be selected against to the extent they would in a virus capable of integrating into the germ line.It is thought that further studying KoRV will allow valuable insight into how endogenous retrovirus develop and incorporate themselves into mammalian genomes.".
- Koala_retrovirus colourName "violet".
- Koala_retrovirus family Retrovirus.
- Koala_retrovirus genus Gammaretrovirus.
- Koala_retrovirus wikiPageID "18308287".
- Koala_retrovirus wikiPageLength "6022".
- Koala_retrovirus wikiPageOutDegree "36".
- Koala_retrovirus wikiPageRevisionID "679624563".
- Koala_retrovirus wikiPageWikiLink AIDS.
- Koala_retrovirus wikiPageWikiLink Cancer.
- Koala_retrovirus wikiPageWikiLink Category:Gammaretroviruses.
- Koala_retrovirus wikiPageWikiLink Category:Koalas.
- Koala_retrovirus wikiPageWikiLink DNA_sequence.
- Koala_retrovirus wikiPageWikiLink Disease_prevalence.
- Koala_retrovirus wikiPageWikiLink Endogenous_retrovirus.
- Koala_retrovirus wikiPageWikiLink Endogenous_virus.
- Koala_retrovirus wikiPageWikiLink Epidemic.
- Koala_retrovirus wikiPageWikiLink Epidemiology.
- Koala_retrovirus wikiPageWikiLink Exogenous.
- Koala_retrovirus wikiPageWikiLink Exogeny.
- Koala_retrovirus wikiPageWikiLink Gammaretrovirus.
- Koala_retrovirus wikiPageWikiLink Gene.
- Koala_retrovirus wikiPageWikiLink Genome.
- Koala_retrovirus wikiPageWikiLink Gibbon.
- Koala_retrovirus wikiPageWikiLink AIDS.
- Koala_retrovirus wikiPageWikiLink Horizontal_disease_transmission.
- Koala_retrovirus wikiPageWikiLink Horizontal_transmission.
- Koala_retrovirus wikiPageWikiLink Immune_deficiency.
- Koala_retrovirus wikiPageWikiLink Immunodeficiency.
- Koala_retrovirus wikiPageWikiLink Kangaroo_Island.
- Koala_retrovirus wikiPageWikiLink Koala.
- Koala_retrovirus wikiPageWikiLink Koalas.
- Koala_retrovirus wikiPageWikiLink Leukaemia.
- Koala_retrovirus wikiPageWikiLink Leukemia.
- Koala_retrovirus wikiPageWikiLink Lymphoma.
- Koala_retrovirus wikiPageWikiLink Malignant_tumour.
- Koala_retrovirus wikiPageWikiLink Nucleic_acid_sequence.
- Koala_retrovirus wikiPageWikiLink Oncovirus.
- Koala_retrovirus wikiPageWikiLink Pathogen.
- Koala_retrovirus wikiPageWikiLink Pathogenic.
- Koala_retrovirus wikiPageWikiLink Prevalence.
- Koala_retrovirus wikiPageWikiLink Reading_frame.
- Koala_retrovirus wikiPageWikiLink Reading_frames.
- Koala_retrovirus wikiPageWikiLink Retroviridae.
- Koala_retrovirus wikiPageWikiLink Retrovirus.
- Koala_retrovirus wikiPageWikiLink Sequence_motif.
- Koala_retrovirus wikiPageWikiLink Vertical_transmission.
- Koala_retrovirus wikiPageWikiLink Vertically_transmitted_infection.
- Koala_retrovirus wikiPageWikiLink Virions.
- Koala_retrovirus wikiPageWikiLink Virus.
- Koala_retrovirus wikiPageWikiLinkText "Koala retrovirus".
- Koala_retrovirus wikiPageWikiLinkText "koala retrovirus".
- Koala_retrovirus wikiPageWikiLinkText "koalas".
- Koala_retrovirus color "violet".
- Koala_retrovirus familia "Retroviridae".
- Koala_retrovirus genus "Gammaretrovirus".
- Koala_retrovirus hasPhotoCollection Koala_retrovirus.
- Koala_retrovirus name "Koala retrovirus".
- Koala_retrovirus subdivision "unclassified Gammaretrovirus".
- Koala_retrovirus subdivisionRanks "species".
- Koala_retrovirus virusGroup "vi".
- Koala_retrovirus wikiPageUsesTemplate Template:Reflist.
- Koala_retrovirus wikiPageUsesTemplate Template:Retroviruses.
- Koala_retrovirus wikiPageUsesTemplate Template:Taxobox.
- Koala_retrovirus subject Category:Gammaretroviruses.
- Koala_retrovirus subject Category:Koalas.
- Koala_retrovirus type Article.
- Koala_retrovirus type Mammal.
- Koala_retrovirus type Species.
- Koala_retrovirus type Article.
- Koala_retrovirus type Mammal.
- Koala_retrovirus type Vombatiform.
- Koala_retrovirus type Thing.
- Koala_retrovirus comment "Koala retrovirus (KoRV) is a retrovirus that is present in many populations of koalas. It has been implicated as the agent of Koala Immune Deficiency Syndrome (KIDS), an AIDS-like immunodeficiency that leaves infected koalas more susceptible to infectious disease and cancers. The virus is thought to be a recently introduced exogenous virus that is also integrating into the koala genome (becoming endogenous).".
- Koala_retrovirus label "Koala retrovirus".
- Koala_retrovirus sameAs Koala-Retrovirus.
- Koala_retrovirus sameAs m.04cwx3y.
- Koala_retrovirus sameAs Retrovirusul_Koala.
- Koala_retrovirus sameAs Koala_retrovirüsü.
- Koala_retrovirus sameAs Q4678387.
- Koala_retrovirus sameAs Q4678387.
- Koala_retrovirus wasDerivedFrom Koala_retrovirus?oldid=679624563.
- Koala_retrovirus isPrimaryTopicOf Koala_retrovirus.
- Koala_retrovirus name "Koala retrovirus".