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- Kelatorphan abstract "Kelatorphan is a drug which acts as a powerful and complete inhibitor of nearly all of the enzymes responsible for catabolism of the endogenous enkephalins, including neutral endopeptidase (NEP), dipeptidyl peptidase III (DPP3), aminopeptidase N (APN), and angiotensin-converting enzyme (ACE). In mice, with the intracerebroventricular co-administration of a 50 µg dose of kelatorphan (this route is necessary because kelatorphan is incapable of crossing the blood-brain-barrier) hence alongside exogenous [Met]enkephalin (ED50 approximately 10 ng), it potentiated the analgesic effects of the latter by 50,000 times. Kelatorphan also displays potent antinociceptive effects alone, and does not depress respiration, although at high doses it actually increases it.".
- Kelatorphan atcPrefix "None".
- Kelatorphan casNumber "92175-57-0".
- Kelatorphan drugbank "DB08040".
- Kelatorphan iupacName "N-[(2R)-2-benzyl-4-(hydroxyamino)-4-oxobutanoyl]-(L)-alanine".
- Kelatorphan pubchem "123982".
- Kelatorphan thumbnail Kelatorphan.svg?width=300.
- Kelatorphan wikiPageID "33861736".
- Kelatorphan wikiPageLength "5073".
- Kelatorphan wikiPageOutDegree "25".
- Kelatorphan wikiPageRevisionID "678938006".
- Kelatorphan wikiPageWikiLink Alanine.
- Kelatorphan wikiPageWikiLink Alanine_aminopeptidase.
- Kelatorphan wikiPageWikiLink Aminopeptidase_N.
- Kelatorphan wikiPageWikiLink Analgesic.
- Kelatorphan wikiPageWikiLink Angiotensin-converting_enzyme.
- Kelatorphan wikiPageWikiLink Antinociceptive.
- Kelatorphan wikiPageWikiLink Blood-brain-barrier.
- Kelatorphan wikiPageWikiLink Blood–brain_barrier.
- Kelatorphan wikiPageWikiLink Catabolism.
- Kelatorphan wikiPageWikiLink Category:Amines.
- Kelatorphan wikiPageWikiLink Category:Amino_acids.
- Kelatorphan wikiPageWikiLink Category:Analgesics.
- Kelatorphan wikiPageWikiLink Category:Enkephalinase_inhibitors.
- Kelatorphan wikiPageWikiLink Category:Opioids.
- Kelatorphan wikiPageWikiLink Cellular_respiration.
- Kelatorphan wikiPageWikiLink DPP3.
- Kelatorphan wikiPageWikiLink Dipeptidyl_peptidase_III.
- Kelatorphan wikiPageWikiLink Drug.
- Kelatorphan wikiPageWikiLink ED50.
- Kelatorphan wikiPageWikiLink Endogenous.
- Kelatorphan wikiPageWikiLink Endogeny_(biology).
- Kelatorphan wikiPageWikiLink Enkephalin.
- Kelatorphan wikiPageWikiLink Enkephalinase_inhibitor.
- Kelatorphan wikiPageWikiLink Enzyme.
- Kelatorphan wikiPageWikiLink Enzyme_inhibitor.
- Kelatorphan wikiPageWikiLink Exogenous.
- Kelatorphan wikiPageWikiLink Exogeny.
- Kelatorphan wikiPageWikiLink Met-enkephalin.
- Kelatorphan wikiPageWikiLink Neprilysin.
- Kelatorphan wikiPageWikiLink Neutral_endopeptidase.
- Kelatorphan wikiPageWikiLink Nociception.
- Kelatorphan wikiPageWikiLink Potency_(pharmacology).
- Kelatorphan wikiPageWikiLinkText "Kelatorphan".
- Kelatorphan atcPrefix "None".
- Kelatorphan c "14".
- Kelatorphan casNumber "92175".
- Kelatorphan chemspiderid "110501".
- Kelatorphan drugbank "DB08040".
- Kelatorphan h "18".
- Kelatorphan hasPhotoCollection Kelatorphan.
- Kelatorphan inchi "1".
- Kelatorphan inchikey "OJCFZTVYDSKXNM-GXSJLCMTBY".
- Kelatorphan iupacName "N-[-2-benzyl-4--4-oxobutanoyl]-(L)-alanine".
- Kelatorphan legalStatus "Non-regulated".
- Kelatorphan molecularWeight "294.303".
- Kelatorphan n "2".
- Kelatorphan o "5".
- Kelatorphan pubchem "123982".
- Kelatorphan smiles "O=C[C@@H]C".
- Kelatorphan stdinchi "1".
- Kelatorphan stdinchikey "OJCFZTVYDSKXNM-GXSJLCMTSA-N".
- Kelatorphan wikiPageUsesTemplate Template:Drugbox.
- Kelatorphan wikiPageUsesTemplate Template:Opioidergics.
- Kelatorphan wikiPageUsesTemplate Template:Reflist.
- Kelatorphan subject Category:Amines.
- Kelatorphan subject Category:Amino_acids.
- Kelatorphan subject Category:Analgesics.
- Kelatorphan subject Category:Enkephalinase_inhibitors.
- Kelatorphan subject Category:Opioids.
- Kelatorphan hypernym Drug.
- Kelatorphan type Biomolecule.
- Kelatorphan type ChemicalSubstance.
- Kelatorphan type Drug.
- Kelatorphan type Group.
- Kelatorphan type Alkaloid.
- Kelatorphan type Analgesic.
- Kelatorphan type Biomolecule.
- Kelatorphan type Drug.
- Kelatorphan type Group.
- Kelatorphan type Inhibitor.
- Kelatorphan type Opioid.
- Kelatorphan type ChemicalObject.
- Kelatorphan type Thing.
- Kelatorphan type Q8386.
- Kelatorphan comment "Kelatorphan is a drug which acts as a powerful and complete inhibitor of nearly all of the enzymes responsible for catabolism of the endogenous enkephalins, including neutral endopeptidase (NEP), dipeptidyl peptidase III (DPP3), aminopeptidase N (APN), and angiotensin-converting enzyme (ACE).".
- Kelatorphan label "Kelatorphan".
- Kelatorphan sameAs m.0hnd4ly.
- Kelatorphan sameAs Kelatorfan.
- Kelatorphan sameAs Kelatorfan.
- Kelatorphan sameAs Q6385498.
- Kelatorphan sameAs Q6385498.
- Kelatorphan wasDerivedFrom Kelatorphan?oldid=678938006.
- Kelatorphan depiction Kelatorphan.svg.
- Kelatorphan isPrimaryTopicOf Kelatorphan.