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- KH_domain abstract "The K Homology (KH) domain is a protein domain that was first identified in the human heterogeneous nuclear ribonucleoprotein (hnRNP) K. An evolutionarily conserved sequence of around 70 amino acids, the KH domain is present in a wide variety of nucleic acid-binding proteins. The KH domain binds RNA, and can function in RNA recognition. It is found in multiple copies in several proteins, where they can function cooperatively or independently. For example, in the AU-rich element RNA-binding protein KSRP, which has 4 KH domains, KH domains 3 and 4 behave as independent binding modules to interact with different regions of the AU-rich RNA targets. The solution structure of the first KH domain of FMR1 and of the C-terminal KH domain of hnRNP K determined by nuclear magnetic resonance (NMR) revealed a beta-alpha-alpha-beta-beta-alpha structure. Autoantibodies to NOVA1, a KH domain protein, cause paraneoplastic opsoclonus ataxia. The KH domain is found at the N-terminus of the ribosomal protein S3. This domain is unusual in that it has a different fold compared to the normal KH domain.".
- KH_domain symbol "KH_1".
- KH_domain symbol "KH_2".
- KH_domain thumbnail PDB_2anr_EBI.png?width=300.
- KH_domain wikiPageID "12545829".
- KH_domain wikiPageLength "7322".
- KH_domain wikiPageOutDegree "50".
- KH_domain wikiPageRevisionID "678936446".
- KH_domain wikiPageWikiLink AKAP1.
- KH_domain wikiPageWikiLink ANKHD1.
- KH_domain wikiPageWikiLink ANKRD17.
- KH_domain wikiPageWikiLink ASCC1.
- KH_domain wikiPageWikiLink BICC1.
- KH_domain wikiPageWikiLink Category:Protein_domains.
- KH_domain wikiPageWikiLink DDX43.
- KH_domain wikiPageWikiLink DDX53.
- KH_domain wikiPageWikiLink DNA.
- KH_domain wikiPageWikiLink DPPA5.
- KH_domain wikiPageWikiLink FMR1.
- KH_domain wikiPageWikiLink FUBP1.
- KH_domain wikiPageWikiLink FUBP3.
- KH_domain wikiPageWikiLink FXR1.
- KH_domain wikiPageWikiLink FXR2.
- KH_domain wikiPageWikiLink Far_upstream_element-binding_protein_1.
- KH_domain wikiPageWikiLink File:KH_fold_types.png.
- KH_domain wikiPageWikiLink GLD1.
- KH_domain wikiPageWikiLink HDLBP.
- KH_domain wikiPageWikiLink HNRPK.
- KH_domain wikiPageWikiLink IGF2BP1.
- KH_domain wikiPageWikiLink IGF2BP2.
- KH_domain wikiPageWikiLink IGF2BP3.
- KH_domain wikiPageWikiLink KHDRBS1.
- KH_domain wikiPageWikiLink KHDRBS2.
- KH_domain wikiPageWikiLink KHDRBS3.
- KH_domain wikiPageWikiLink KHSRP.
- KH_domain wikiPageWikiLink KRR1.
- KH_domain wikiPageWikiLink MEX3A.
- KH_domain wikiPageWikiLink MEX3B.
- KH_domain wikiPageWikiLink MEX3C.
- KH_domain wikiPageWikiLink MEX3D.
- KH_domain wikiPageWikiLink NOVA1.
- KH_domain wikiPageWikiLink NOVA2.
- KH_domain wikiPageWikiLink PCBP1.
- KH_domain wikiPageWikiLink PCBP2.
- KH_domain wikiPageWikiLink PCBP3.
- KH_domain wikiPageWikiLink PCBP4.
- KH_domain wikiPageWikiLink PNO1.
- KH_domain wikiPageWikiLink PNPT1.
- KH_domain wikiPageWikiLink Paraneoplastic_opsoclonus_ataxia.
- KH_domain wikiPageWikiLink Protein_K_(gene_expression).
- KH_domain wikiPageWikiLink Protein_domain.
- KH_domain wikiPageWikiLink QKI.
- KH_domain wikiPageWikiLink RNA.
- KH_domain wikiPageWikiLink SF1_(gene).
- KH_domain wikiPageWikiLink Sequence_motif.
- KH_domain wikiPageWikiLink SsDNA.
- KH_domain wikiPageWikiLink TDRKH.
- KH_domain wikiPageWikiLink Vigilin.
- KH_domain wikiPageWikiLinkText "K homology domain".
- KH_domain wikiPageWikiLinkText "K-Homology Domain (KH domain)".
- KH_domain wikiPageWikiLinkText "K-homology (KH) domain".
- KH_domain wikiPageWikiLinkText "KH domain".
- KH_domain wikiPageWikiLinkText "KH-type".
- KH_domain caption "Structure of a KH domain from the human protein vigilin.".
- KH_domain hasPhotoCollection KH_domain.
- KH_domain interpro "IPR004044".
- KH_domain interpro "IPR018111".
- KH_domain name "KH domain".
- KH_domain pdb ", , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,".
- KH_domain pdb ", , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,".
- KH_domain pfam "PF00013".
- KH_domain pfam "PF07650".
- KH_domain pfamClan "CL0007".
- KH_domain prosite "PS50823".
- KH_domain scop "1".
- KH_domain smart "KH".
- KH_domain symbol "KH_1".
- KH_domain symbol "KH_2".
- KH_domain wikiPageUsesTemplate Template:Infobox_protein_family.
- KH_domain wikiPageUsesTemplate Template:InterPro_content.
- KH_domain wikiPageUsesTemplate Template:Reflist.
- KH_domain subject Category:Protein_domains.
- KH_domain hypernym Domain.
- KH_domain type Biomolecule.
- KH_domain type Protein.
- KH_domain type Chemical.
- KH_domain type Domain.
- KH_domain type Thing.
- KH_domain type Q206229.
- KH_domain type Q8054.
- KH_domain comment "The K Homology (KH) domain is a protein domain that was first identified in the human heterogeneous nuclear ribonucleoprotein (hnRNP) K. An evolutionarily conserved sequence of around 70 amino acids, the KH domain is present in a wide variety of nucleic acid-binding proteins. The KH domain binds RNA, and can function in RNA recognition. It is found in multiple copies in several proteins, where they can function cooperatively or independently.".
- KH_domain label "KH domain".
- KH_domain sameAs m.0cmf1g7.
- KH_domain sameAs Q6330434.
- KH_domain sameAs Q6330434.
- KH_domain wasDerivedFrom KH_domain?oldid=678936446.
- KH_domain depiction PDB_2anr_EBI.png.
- KH_domain isPrimaryTopicOf KH_domain.