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- K562_cells abstract "K562 cells were the first human immortalised myelogenous leukemia line to be established. K562 cells are of the erythroleukemia type, and the line is derived from a 53-year-old female CML patient in blast crisis. The cells are non-adherent and rounded, are positive for the bcr:abl fusion gene, and bear some proteomic resemblance to both undifferentiated granulocytes and erythrocytes.In culture they exhibit much less clumping than many other suspension lines, presumably due to the downregulation of surface adhesion molecules by bcr:abl. However, another study suggests that bcr:abl over-expression may actually increase cell adherence to cell culture plastic. K562 cells can spontaneously develop characteristics similar to early-stage erythrocytes, granulocytes and monocytes and are easily killed by natural killer cells as they lack the MHC complex required to inhibit NK activity. They also lack any trace of Epstein-Barr virus and other herpesviruses. In addition to the Philadelphia chromosome they also exhibit a second reciprocal translocation between the long arm of chromosome 15 with chromosome 17.Two sub-lines are available which express MHC class-I A2 and A3.".
- K562_cells wikiPageID "3354944".
- K562_cells wikiPageLength "6386".
- K562_cells wikiPageOutDegree "16".
- K562_cells wikiPageRevisionID "681858644".
- K562_cells wikiPageWikiLink Bcr:abl.
- K562_cells wikiPageWikiLink Blast_crisis.
- K562_cells wikiPageWikiLink Category:Cell_lines.
- K562_cells wikiPageWikiLink Chromosome.
- K562_cells wikiPageWikiLink Chronic_myelogenous_leukemia.
- K562_cells wikiPageWikiLink Downregulation.
- K562_cells wikiPageWikiLink Downregulation_and_upregulation.
- K562_cells wikiPageWikiLink Epstein-Barr_virus.
- K562_cells wikiPageWikiLink Epstein–Barr_virus.
- K562_cells wikiPageWikiLink Erythrocytes.
- K562_cells wikiPageWikiLink Fusion_gene.
- K562_cells wikiPageWikiLink Granulocyte.
- K562_cells wikiPageWikiLink Granulocytes.
- K562_cells wikiPageWikiLink Leukemia.
- K562_cells wikiPageWikiLink Major_histocompatibility_complex.
- K562_cells wikiPageWikiLink Monocyte.
- K562_cells wikiPageWikiLink Monocytes.
- K562_cells wikiPageWikiLink Natural_killer_cell.
- K562_cells wikiPageWikiLink Natural_killer_cells.
- K562_cells wikiPageWikiLink Philadelphia_chromosome.
- K562_cells wikiPageWikiLink Red_blood_cell.
- K562_cells wikiPageWikiLinkText "K562 cells".
- K562_cells wikiPageWikiLinkText "K562".
- K562_cells wikiPageWikiLinkText "k562 cells".
- K562_cells hasPhotoCollection K562_cells.
- K562_cells wikiPageUsesTemplate Template:Cell-biology-stub.
- K562_cells wikiPageUsesTemplate Template:MeshNumber.
- K562_cells subject Category:Cell_lines.
- K562_cells hypernym Line.
- K562_cells type Article.
- K562_cells type Article.
- K562_cells type Line.
- K562_cells comment "K562 cells were the first human immortalised myelogenous leukemia line to be established. K562 cells are of the erythroleukemia type, and the line is derived from a 53-year-old female CML patient in blast crisis.".
- K562_cells label "K562 cells".
- K562_cells sameAs m.097c_l.
- K562_cells sameAs Q6324626.
- K562_cells sameAs Q6324626.
- K562_cells wasDerivedFrom K562_cells?oldid=681858644.
- K562_cells isPrimaryTopicOf K562_cells.