Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Jaagsiekte> ?p ?o }
Showing triples 1 to 59 of
59
with 100 triples per page.
- Jaagsiekte abstract "Jaagsiekte (yaag·zeek·te) is a chronic and contagious disease of the lungs in sheep and goats first described in 1865. Its name derives from Afrikaans and means "Chasing Sickness" such that animals afflicted with the disease are in respiratory distress as if they are out of breath from being chased. It is also referred to as Ovine Pulmonary Adenocarcinoma (OPA). During end-stage disease, animals exude a foamy white fluid from the nose which is thought to be the mode of transmission between animals. Dissected lungs from afflicted sheep are interspersed with multifocal tumors. Some of these are small discrete nodules and others will involve the entire half of a lung lobule. The disease is caused by a retrovirus called the Jaagsiekte Sheep Retrovirus (JSRV) that acutely transforms the lung epithelia into cancerous cells. Specifically, Type-2 pneumocytes and club (Clara) cells of the lung are the likely target for JSRV transformation. The tumors formed there exhibit the overactive secretory functions which are a hallmark of OPA.OPA is an infectious disease of sheep and recently has been used as an animal model for human lung cancer. It is common in the UK and in South Africa. The disease has a long incubation period and is not seen until sheep reach at least 2 years of age. Clinical symptoms include weight loss, loss of appetite, and respiratory difficulty which is associated with obvious movement of the abdomen and high pitched noises. Fluid accumulates in the respiratory tract and the disease ultimately causes death. The retroviral antigen levels of JSRV are very high in OPA tumors and can be detected in the lung secretions of infected sheep. A common field assessment for Jaagsiekte is the "wheelbarrow test" where one lifts the hind legs of the animal above the head to observe lung exudate flow out the nose and mouth. This fluid contains infectious JSRV. It is thought that infected animals secrete the virus before showing clinical symptoms and the virus is therefore easily spread within flocks. The disease is histologically similar to human bronchioalveolar carcinoma which accounts for approximately 25% of all diagnosed human lung cancers.Dolly the sheep, the first mammal successfully cloned from an adult somatic cell, was euthanized after it was confirmed that she had Jaagsiekte.".
- Jaagsiekte wikiPageID "1567101".
- Jaagsiekte wikiPageLength "3930".
- Jaagsiekte wikiPageOutDegree "25".
- Jaagsiekte wikiPageRevisionID "668287273".
- Jaagsiekte wikiPageWikiLink Adenocarcinoma.
- Jaagsiekte wikiPageWikiLink Adenocarcinoma_in_situ_of_the_lung.
- Jaagsiekte wikiPageWikiLink Afrikaans.
- Jaagsiekte wikiPageWikiLink Alveolar_cells.
- Jaagsiekte wikiPageWikiLink Antigen.
- Jaagsiekte wikiPageWikiLink Bronchioalveolar_carcinoma.
- Jaagsiekte wikiPageWikiLink Category:Animal_virology.
- Jaagsiekte wikiPageWikiLink Category:Sheep_and_goat_diseases.
- Jaagsiekte wikiPageWikiLink Club_cell.
- Jaagsiekte wikiPageWikiLink Dolly_(sheep).
- Jaagsiekte wikiPageWikiLink Dolly_the_sheep.
- Jaagsiekte wikiPageWikiLink Epithelium.
- Jaagsiekte wikiPageWikiLink Exudate.
- Jaagsiekte wikiPageWikiLink Histologically.
- Jaagsiekte wikiPageWikiLink Histology.
- Jaagsiekte wikiPageWikiLink Human.
- Jaagsiekte wikiPageWikiLink JSRV.
- Jaagsiekte wikiPageWikiLink Jaagsiekte_Sheep_Retrovirus.
- Jaagsiekte wikiPageWikiLink Jaagsiekte_sheep_retrovirus.
- Jaagsiekte wikiPageWikiLink Lung.
- Jaagsiekte wikiPageWikiLink Neoplasm.
- Jaagsiekte wikiPageWikiLink Nodule_(medicine).
- Jaagsiekte wikiPageWikiLink Ovine.
- Jaagsiekte wikiPageWikiLink Pneumocytes.
- Jaagsiekte wikiPageWikiLink Retrovirus.
- Jaagsiekte wikiPageWikiLink Sheep.
- Jaagsiekte wikiPageWikiLink South_Africa.
- Jaagsiekte wikiPageWikiLink Tumors.
- Jaagsiekte wikiPageWikiLink UK.
- Jaagsiekte wikiPageWikiLink United_Kingdom.
- Jaagsiekte wikiPageWikiLink Wheelbarrow.
- Jaagsiekte wikiPageWikiLinkText "Jaagsiekte".
- Jaagsiekte wikiPageWikiLinkText "OPA".
- Jaagsiekte hasPhotoCollection Jaagsiekte.
- Jaagsiekte wikiPageUsesTemplate Template:Cite_journal.
- Jaagsiekte wikiPageUsesTemplate Template:Morefootnotes.
- Jaagsiekte wikiPageUsesTemplate Template:Reflist.
- Jaagsiekte wikiPageUsesTemplate Template:Veterinary-med-stub.
- Jaagsiekte subject Category:Animal_virology.
- Jaagsiekte subject Category:Sheep_and_goat_diseases.
- Jaagsiekte hypernym Disease.
- Jaagsiekte type Article.
- Jaagsiekte type Disease.
- Jaagsiekte type Article.
- Jaagsiekte comment "Jaagsiekte (yaag·zeek·te) is a chronic and contagious disease of the lungs in sheep and goats first described in 1865. Its name derives from Afrikaans and means "Chasing Sickness" such that animals afflicted with the disease are in respiratory distress as if they are out of breath from being chased. It is also referred to as Ovine Pulmonary Adenocarcinoma (OPA).".
- Jaagsiekte label "Jaagsiekte".
- Jaagsiekte sameAs Lungenadenomatose.
- Jaagsiekte sameAs Jaagsiekte.
- Jaagsiekte sameAs Jaagsiekte.
- Jaagsiekte sameAs m.05b_5l.
- Jaagsiekte sameAs Q695812.
- Jaagsiekte sameAs Q695812.
- Jaagsiekte wasDerivedFrom Jaagsiekte?oldid=668287273.
- Jaagsiekte isPrimaryTopicOf Jaagsiekte.