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- Israpafant abstract "Israpafant (Y-24180) is a drug which acts as a selective antagonist for the platelet-activating factor receptor, and was originally developed for the treatment of asthma. Its chemical structure is a triazolothienodiazepine, closely related to the sedative benzodiazepine derivative etizolam. However israpafant binds far more tightly to the platelet-activating factor receptor, with an IC50 of 0.84nM for inhibiting PAF-induced human platelet aggregation (compared to etizolam's IC50 of 998nM at this target), while it binds only weakly to benzodiazepine receptors, with a Ki of 3680nM. Israpafant has been found to inhibit the activation of eosinophil cells, and consequently delays the development of immune responses. It has also been shown to have anti-nephrotoxic properties, and to mobilise calcium transport.".
- Israpafant casNumber "117279-73-9".
- Israpafant iupacName "4-(2-Chlorophenyl)-6,9-dimethyl-2-[2-[4-(2-methylpropyl)phenyl]ethyl]-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine".
- Israpafant pubchem "636426".
- Israpafant thumbnail Israpafant.svg?width=300.
- Israpafant wikiPageID "43380450".
- Israpafant wikiPageLength "4327".
- Israpafant wikiPageOutDegree "8".
- Israpafant wikiPageRevisionID "678513958".
- Israpafant wikiPageWikiLink Asthma.
- Israpafant wikiPageWikiLink Benzodiazepine.
- Israpafant wikiPageWikiLink Category:Thienodiazepines.
- Israpafant wikiPageWikiLink Eosinophil.
- Israpafant wikiPageWikiLink Eosinophil_granulocyte.
- Israpafant wikiPageWikiLink Etizolam.
- Israpafant wikiPageWikiLink JQ1.
- Israpafant wikiPageWikiLink Nephrotoxic.
- Israpafant wikiPageWikiLink Nephrotoxicity.
- Israpafant wikiPageWikiLink Platelet-activating_factor_receptor.
- Israpafant wikiPageWikiLinkText "Israpafant".
- Israpafant wikiPageWikiLinkText "israpafant".
- Israpafant c "28".
- Israpafant casNumber "117279".
- Israpafant chemspiderid "552203".
- Israpafant cl "1".
- Israpafant h "29".
- Israpafant hasPhotoCollection Israpafant.
- Israpafant inchi "1".
- Israpafant inchikey "RMSWMRJVUJSDGN-GOSISDBHBU".
- Israpafant iupacName "4".
- Israpafant legalStatus "Investigational New Drug".
- Israpafant molecularWeight "489.074".
- Israpafant n "4".
- Israpafant pubchem "636426".
- Israpafant s "1".
- Israpafant smiles "C[C@@H]1C2=NN=CC".
- Israpafant stdinchi "1".
- Israpafant stdinchikey "RMSWMRJVUJSDGN-GOSISDBHSA-N".
- Israpafant wikiPageUsesTemplate Template:Benzodiazepines.
- Israpafant wikiPageUsesTemplate Template:Drug-stub.
- Israpafant wikiPageUsesTemplate Template:Drugbox.
- Israpafant wikiPageUsesTemplate Template:PAF_signaling.
- Israpafant wikiPageUsesTemplate Template:Reflist.
- Israpafant subject Category:Thienodiazepines.
- Israpafant hypernym Drug.
- Israpafant type ChemicalSubstance.
- Israpafant type Drug.
- Israpafant type ChemicalObject.
- Israpafant type Thing.
- Israpafant type Q8386.
- Israpafant comment "Israpafant (Y-24180) is a drug which acts as a selective antagonist for the platelet-activating factor receptor, and was originally developed for the treatment of asthma. Its chemical structure is a triazolothienodiazepine, closely related to the sedative benzodiazepine derivative etizolam.".
- Israpafant label "Israpafant".
- Israpafant sameAs m.011f0g8f.
- Israpafant sameAs Q18352394.
- Israpafant sameAs Q18352394.
- Israpafant wasDerivedFrom Israpafant?oldid=678513958.
- Israpafant depiction Israpafant.svg.
- Israpafant isPrimaryTopicOf Israpafant.