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- Isopregnanolone abstract "Isopregnanolone, also known as isoallopregnanolone and epiallopregnanolone, as well as sepranolone (INN), and as 3β-hydoxy-5α-pregnan-20-one or 3β,5α-tetrahydroprogesterone (3β,5α-THP), is an endogenous neurosteroid and a natural 3β-epimer of allopregnanolone. It has been reported to act as a subunit-selective negative allosteric modulator of the GABAA receptor, and antagonizes in animals and humans some but not all of the GABAA receptor-mediated effects of allopregnanolone, such as anesthesia, sedation, and reduced saccadic eye movements, but not learning impairment. Isopregnanolone has no hormonal effects and appears to have no effect on the GABAA receptor by itself; it selectively antagonizes allopregnanolone and does not affect the effects of other types of GABAA receptor positive allosteric modulators such as benzodiazepines or barbiturates.Isopregnanolone is synthesized from progesterone in the body by the actions of the enzymes 5α-reductase and 3β-hydroxysteroid dehydrogenase (with 5α-dihydroprogesterone as the intermediate in this two-step transformation) and can be reversibly metabolized into allopregnanolone by the enzyme 3α-hydroxysteroid dehydrogenase. Levels of isopregnanolone, progesterone, and allopregnanolone are highly correlated across the menstrual cycle and throughout pregnancy. The concentrations of isopregnanolone are significantly less than those of progesterone and allopregnanolone; about half of those of allopregnanolone, to be precise. Isopregnanolone has a relatively long serum half-life of 14 hours in humans.".
- Isopregnanolone iupacName "3β-Hydoxy-5α-pregnan-20-one".
- Isopregnanolone thumbnail Isopregnanolone.svg?width=300.
- Isopregnanolone wikiPageID "43150974".
- Isopregnanolone wikiPageLength "5720".
- Isopregnanolone wikiPageOutDegree "35".
- Isopregnanolone wikiPageRevisionID "682020339".
- Isopregnanolone wikiPageWikiLink 3-alpha-HSD.
- Isopregnanolone wikiPageWikiLink 3beta-Hydroxysteroid_dehydrogenase.
- Isopregnanolone wikiPageWikiLink 3α-hydroxysteroid_dehydrogenase.
- Isopregnanolone wikiPageWikiLink 3β-Androstanediol.
- Isopregnanolone wikiPageWikiLink 3β-Dihydroprogesterone.
- Isopregnanolone wikiPageWikiLink 3β-hydroxysteroid_dehydrogenase.
- Isopregnanolone wikiPageWikiLink 5-alpha_reductase.
- Isopregnanolone wikiPageWikiLink 5α-Androstane-3β,17β-diol.
- Isopregnanolone wikiPageWikiLink 5α-Dihydroprogesterone.
- Isopregnanolone wikiPageWikiLink 5α-dihydroprogesterone.
- Isopregnanolone wikiPageWikiLink 5α-reductase.
- Isopregnanolone wikiPageWikiLink Allopregnanolone.
- Isopregnanolone wikiPageWikiLink Allosteric_modulator.
- Isopregnanolone wikiPageWikiLink Anesthesia.
- Isopregnanolone wikiPageWikiLink Barbiturate.
- Isopregnanolone wikiPageWikiLink Benzodiazepine.
- Isopregnanolone wikiPageWikiLink Biosynthesis.
- Isopregnanolone wikiPageWikiLink Category:GABAA_receptor_negative_allosteric_modulators.
- Isopregnanolone wikiPageWikiLink Category:Neurosteroids.
- Isopregnanolone wikiPageWikiLink Chemical_intermediate.
- Isopregnanolone wikiPageWikiLink Endogenous.
- Isopregnanolone wikiPageWikiLink Endogeny_(biology).
- Isopregnanolone wikiPageWikiLink Enzyme.
- Isopregnanolone wikiPageWikiLink Epimer.
- Isopregnanolone wikiPageWikiLink Epipregnanolone.
- Isopregnanolone wikiPageWikiLink GABAA_receptor.
- Isopregnanolone wikiPageWikiLink Half-life.
- Isopregnanolone wikiPageWikiLink Hormonal.
- Isopregnanolone wikiPageWikiLink Hormone.
- Isopregnanolone wikiPageWikiLink International_Nonproprietary_Name.
- Isopregnanolone wikiPageWikiLink Learning_disability.
- Isopregnanolone wikiPageWikiLink Learning_impairment.
- Isopregnanolone wikiPageWikiLink Menstrual_cycle.
- Isopregnanolone wikiPageWikiLink Natural_product.
- Isopregnanolone wikiPageWikiLink Negative_allosteric_modulator.
- Isopregnanolone wikiPageWikiLink Neuroactive_steroid.
- Isopregnanolone wikiPageWikiLink Neurosteroid.
- Isopregnanolone wikiPageWikiLink Positive_allosteric_modulator.
- Isopregnanolone wikiPageWikiLink Pregnancy.
- Isopregnanolone wikiPageWikiLink Pregnanolone.
- Isopregnanolone wikiPageWikiLink Progesterone.
- Isopregnanolone wikiPageWikiLink Reaction_intermediate.
- Isopregnanolone wikiPageWikiLink Receptor_antagonist.
- Isopregnanolone wikiPageWikiLink Saccade.
- Isopregnanolone wikiPageWikiLink Saccadic_eye_movement.
- Isopregnanolone wikiPageWikiLink Sedation.
- Isopregnanolone wikiPageWikiLink Subunit.
- Isopregnanolone wikiPageWikiLinkText "Isopregnanolone".
- Isopregnanolone wikiPageWikiLinkText "isopregnanolone".
- Isopregnanolone hasPhotoCollection Isopregnanolone.
- Isopregnanolone imagefile "Isopregnanolone.svg".
- Isopregnanolone imagesize "200".
- Isopregnanolone iupacname "3".
- Isopregnanolone othernames "Isoallopregnanolone, epiallopregnanolone, sepranolone, 3β,5α-tetrahydroprogesterone".
- Isopregnanolone wikiPageUsesTemplate Template:Chembox.
- Isopregnanolone wikiPageUsesTemplate Template:GABAergics.
- Isopregnanolone wikiPageUsesTemplate Template:Reflist.
- Isopregnanolone wikiPageUsesTemplate Template:Steroid-stub.
- Isopregnanolone wikiPageUsesTemplate Template:Steroid_hormones.
- Isopregnanolone subject Category:GABAA_receptor_negative_allosteric_modulators.
- Isopregnanolone subject Category:Neurosteroids.
- Isopregnanolone hypernym Neurosteroid.
- Isopregnanolone type ChemicalCompound.
- Isopregnanolone type ChemicalSubstance.
- Isopregnanolone type ChemicalObject.
- Isopregnanolone type Thing.
- Isopregnanolone type Q11173.
- Isopregnanolone comment "Isopregnanolone, also known as isoallopregnanolone and epiallopregnanolone, as well as sepranolone (INN), and as 3β-hydoxy-5α-pregnan-20-one or 3β,5α-tetrahydroprogesterone (3β,5α-THP), is an endogenous neurosteroid and a natural 3β-epimer of allopregnanolone.".
- Isopregnanolone label "Isopregnanolone".
- Isopregnanolone sameAs m.01116tl6.
- Isopregnanolone sameAs Q18352362.
- Isopregnanolone sameAs Q18352362.
- Isopregnanolone wasDerivedFrom Isopregnanolone?oldid=682020339.
- Isopregnanolone depiction Isopregnanolone.svg.
- Isopregnanolone isPrimaryTopicOf Isopregnanolone.