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- Intimin abstract "Intimin is a virulence factor (adhesin) of EPEC (e.g. E. coli O127:H6) and EHEC (e.g. E. coli O157:H7) E. coli strains. It is an attaching and effacing (A/E) protein which with other virulence factors is responsible for enteropathogenic and enterohaemorrhagic diarrhoea.Intimin is expressed on the bacterial cell surface where it can bind to its receptor Tir (Translocated intimin receptor). Tir, along with over 25 other bacterial proteins, is secreted from attaching and effacing E. coli directly into the cytoplasm of intestinal epithelial cells by a Type three secretion system. Once within the cytoplasm of the host cell, Tir is inserted into the plasma membrane, allowing surface exposure and intimin binding.The structure of the C-terminal domain has been solved and shown to have a C-lectin type of structure.It is a 94 kDa outer membrane protein encoded by eaeA gene in the locus of enterocyte effacement. Mutations in the eaeA gene result in loss of ability to cause A/E lesions, and is required for full virulence in infected volunteers and animal models. The N-terminal domains of intimin from A/E lesion forming pathogens have high homology with each other and to invasin from Yersinia pseudotuberculosis and Yersinia enterocolitica, whereas the C-terminal domains show less homology.Antibodies to intimin are present in: (1) Immune colostrum from mothers in EPEC endemic areas, (2) The serum of EPEC/EHEC infected children and EPEC infected volunteers, and (3) Secretions of Citrobacter rodentium infected mice.".
- Intimin symbol "Intimin_C".
- Intimin thumbnail PDB_1e5u_EBI.jpg?width=300.
- Intimin wikiPageID "10054131".
- Intimin wikiPageLength "3489".
- Intimin wikiPageOutDegree "18".
- Intimin wikiPageRevisionID "678929637".
- Intimin wikiPageWikiLink Adhesin.
- Intimin wikiPageWikiLink Bacterial_adhesin.
- Intimin wikiPageWikiLink Biomolecular_structure.
- Intimin wikiPageWikiLink C-terminal.
- Intimin wikiPageWikiLink C-terminus.
- Intimin wikiPageWikiLink Category:Protein_domains.
- Intimin wikiPageWikiLink Category:Virulence_factors.
- Intimin wikiPageWikiLink Diarrhea.
- Intimin wikiPageWikiLink Diarrhoea.
- Intimin wikiPageWikiLink E._coli.
- Intimin wikiPageWikiLink EHEC.
- Intimin wikiPageWikiLink Enterohemorrhagic.
- Intimin wikiPageWikiLink Enteropathogenic_E._coli.
- Intimin wikiPageWikiLink Escherichia_coli.
- Intimin wikiPageWikiLink Escherichia_coli_O157:H7.
- Intimin wikiPageWikiLink O127:H6.
- Intimin wikiPageWikiLink O157.
- Intimin wikiPageWikiLink Pathogenic_Escherichia_coli.
- Intimin wikiPageWikiLink Protein_domain.
- Intimin wikiPageWikiLink Secondary_structure.
- Intimin wikiPageWikiLink Tir_(receptor).
- Intimin wikiPageWikiLink Type_three_secretion_system.
- Intimin wikiPageWikiLink Verotoxin-producing_Escherichia_coli.
- Intimin wikiPageWikiLink Virulence_factor.
- Intimin wikiPageWikiLink Yersinia_enterocolitica.
- Intimin wikiPageWikiLinkText "intimin".
- Intimin caption "nmr representative structure of intimin-190 from enteropathogenic e. coli".
- Intimin hasPhotoCollection Intimin.
- Intimin interpro "IPR013117".
- Intimin name "Intimin C-type lectin domain".
- Intimin pfam "PF07979".
- Intimin pfamClan "CL0056".
- Intimin symbol "Intimin_C".
- Intimin wikiPageUsesTemplate Template:Infobox_protein_family.
- Intimin wikiPageUsesTemplate Template:InterPro_content.
- Intimin wikiPageUsesTemplate Template:Microbiology-stub.
- Intimin wikiPageUsesTemplate Template:Reflist.
- Intimin subject Category:Protein_domains.
- Intimin subject Category:Virulence_factors.
- Intimin hypernym Factor.
- Intimin type Biomolecule.
- Intimin type Protein.
- Intimin type Chemical.
- Intimin type Domain.
- Intimin type Thing.
- Intimin type Q206229.
- Intimin type Q8054.
- Intimin comment "Intimin is a virulence factor (adhesin) of EPEC (e.g. E. coli O127:H6) and EHEC (e.g. E. coli O157:H7) E. coli strains. It is an attaching and effacing (A/E) protein which with other virulence factors is responsible for enteropathogenic and enterohaemorrhagic diarrhoea.Intimin is expressed on the bacterial cell surface where it can bind to its receptor Tir (Translocated intimin receptor). Tir, along with over 25 other bacterial proteins, is secreted from attaching and effacing E.".
- Intimin label "Intimin".
- Intimin sameAs Intimin.
- Intimin sameAs m.02q09__.
- Intimin sameAs Q1432524.
- Intimin sameAs Q1432524.
- Intimin wasDerivedFrom Intimin?oldid=678929637.
- Intimin depiction PDB_1e5u_EBI.jpg.
- Intimin isPrimaryTopicOf Intimin.