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- Integrin_alpha_M abstract "Integrin alpha M (ITGAM) is one protein subunit that forms the heterodimeric integrin alpha-M beta-2 (αMβ2) molecule, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3). ITGAM is also known as CR3A, and cluster of differentiation molecule 11B (CD11B). The second chain of αMβ2 is the common integrin β2 subunit known as CD18, and integrin αMβ2 thus belongs to the β2 subfamily (or leukocyte) integrins.αMβ2 is expressed on the surface of many leukocytes involved in the innate immune system, including monocytes, granulocytes, macrophages, and natural killer cells. It mediates inflammation by regulating leukocyte adhesion and migration and has been implicated in several immune processes such as phagocytosis, cell-mediated cytotoxicity, chemotaxis and cellular activation. It is involved in the complement system due to its capacity to bind inactivated complement component 3b (iC3b). The ITGAM (alpha) subunit of integrin αMβ2 is directly involved in causing the adhesion and spreading of cells but cannot mediate cellular migration without the presence of the β2 (CD18) subunit.In genomewide association studies, single nucleotide polymorphisms in ITGAM had the strongest association with systemic lupus erythematosus, with an odds ratio of 1.65 for the T allele of rs9888739 and lupus.In histopathology, immunohistochemistry with antibodies against CD11B is frequently used to identify macrophages and microglia.".
- Integrin_alpha_M entrezgene "3684".
- Integrin_alpha_M wikiPageExternalLink report.cgi?report=orth_overview&gene_id=3684.
- Integrin_alpha_M wikiPageExternalLink index.shtml.
- Integrin_alpha_M wikiPageExternalLink humancdchart.htm.
- Integrin_alpha_M wikiPageExternalLink mousecdchart.htm.
- Integrin_alpha_M wikiPageID "5990252".
- Integrin_alpha_M wikiPageLength "5086".
- Integrin_alpha_M wikiPageOutDegree "23".
- Integrin_alpha_M wikiPageRevisionID "678928765".
- Integrin_alpha_M wikiPageWikiLink CD18.
- Integrin_alpha_M wikiPageWikiLink Category:Proteins.
- Integrin_alpha_M wikiPageWikiLink Cell_adhesion.
- Integrin_alpha_M wikiPageWikiLink Chemotaxis.
- Integrin_alpha_M wikiPageWikiLink Cluster_of_differentiation.
- Integrin_alpha_M wikiPageWikiLink Complement_component_3.
- Integrin_alpha_M wikiPageWikiLink Complement_component_3b.
- Integrin_alpha_M wikiPageWikiLink Complement_receptor.
- Integrin_alpha_M wikiPageWikiLink Complement_system.
- Integrin_alpha_M wikiPageWikiLink Granulocyte.
- Integrin_alpha_M wikiPageWikiLink Heterodimer.
- Integrin_alpha_M wikiPageWikiLink Histopathology.
- Integrin_alpha_M wikiPageWikiLink Innate_immune_system.
- Integrin_alpha_M wikiPageWikiLink Integrin.
- Integrin_alpha_M wikiPageWikiLink Leukocyte.
- Integrin_alpha_M wikiPageWikiLink Macrophage.
- Integrin_alpha_M wikiPageWikiLink Macrophage-1_antigen.
- Integrin_alpha_M wikiPageWikiLink Macrophages.
- Integrin_alpha_M wikiPageWikiLink Microglia.
- Integrin_alpha_M wikiPageWikiLink Monocyte.
- Integrin_alpha_M wikiPageWikiLink Natural_killer_cell.
- Integrin_alpha_M wikiPageWikiLink Phagocytosis.
- Integrin_alpha_M wikiPageWikiLink Protein_dimer.
- Integrin_alpha_M wikiPageWikiLink Systemic_lupus_erythematosus.
- Integrin_alpha_M wikiPageWikiLink White_blood_cell.
- Integrin_alpha_M wikiPageWikiLinkText "CD11b".
- Integrin_alpha_M wikiPageWikiLinkText "CD11b+".
- Integrin_alpha_M wikiPageWikiLinkText "ITGAM".
- Integrin_alpha_M wikiPageWikiLinkText "Integrin alpha M".
- Integrin_alpha_M wikiPageWikiLinkText "Mac-1".
- Integrin_alpha_M hasPhotoCollection Integrin_alpha_M.
- Integrin_alpha_M requireManualInspection "no".
- Integrin_alpha_M updateCitations "yes".
- Integrin_alpha_M updatePage "yes".
- Integrin_alpha_M updateProteinBox "yes".
- Integrin_alpha_M updateSummary "no".
- Integrin_alpha_M wikiPageUsesTemplate Template:Clusters_of_differentiation.
- Integrin_alpha_M wikiPageUsesTemplate Template:Complement_system.
- Integrin_alpha_M wikiPageUsesTemplate Template:Gene-16-stub.
- Integrin_alpha_M wikiPageUsesTemplate Template:Integrins.
- Integrin_alpha_M wikiPageUsesTemplate Template:MeshName.
- Integrin_alpha_M wikiPageUsesTemplate Template:PBB.
- Integrin_alpha_M wikiPageUsesTemplate Template:PBB_Controls.
- Integrin_alpha_M wikiPageUsesTemplate Template:PBB_Further_reading.
- Integrin_alpha_M wikiPageUsesTemplate Template:PDB_Gallery.
- Integrin_alpha_M wikiPageUsesTemplate Template:Refbegin.
- Integrin_alpha_M wikiPageUsesTemplate Template:Refend.
- Integrin_alpha_M wikiPageUsesTemplate Template:Reflist.
- Integrin_alpha_M subject Category:Proteins.
- Integrin_alpha_M hypernym Subunit.
- Integrin_alpha_M type Biomolecule.
- Integrin_alpha_M type Protein.
- Integrin_alpha_M type Biomolecule.
- Integrin_alpha_M type Nutrient.
- Integrin_alpha_M type Thing.
- Integrin_alpha_M type Q206229.
- Integrin_alpha_M type Q8054.
- Integrin_alpha_M comment "Integrin alpha M (ITGAM) is one protein subunit that forms the heterodimeric integrin alpha-M beta-2 (αMβ2) molecule, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3). ITGAM is also known as CR3A, and cluster of differentiation molecule 11B (CD11B).".
- Integrin_alpha_M label "Integrin alpha M".
- Integrin_alpha_M sameAs CD11b.
- Integrin_alpha_M sameAs Integrina_alfa_M.
- Integrin_alpha_M sameAs Integrina_alfa_M.
- Integrin_alpha_M sameAs m.0fjg2s.
- Integrin_alpha_M sameAs Интегрин_альфа-M.
- Integrin_alpha_M sameAs Q3799301.
- Integrin_alpha_M sameAs Q3799301.
- Integrin_alpha_M wasDerivedFrom Integrin_alpha_M?oldid=678928765.
- Integrin_alpha_M isPrimaryTopicOf Integrin_alpha_M.