Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Infliximab> ?p ?o }
- Infliximab abstract "Infliximab (INN; trade names Remicade, Remsima, Inflectra) is a chimeric monoclonal antibody against tumour necrosis factor alpha (TNF-α) used to treat autoimmune diseases.Infliximab was approved by the U.S. Food and Drug Administration (FDA) for the treatment of Crohn's disease, ulcerative colitis, psoriasis, psoriatic arthritis, ankylosing spondylitis, and rheumatoid arthritis. It is used off-label outside its FDA approval for Behçet's disease and other conditions. Infliximab works by binding to TNF-α. TNF-α is a chemical messenger (cytokine) and a key part of the autoimmune reaction. In rheumatoid arthritis, infliximab seems to work by preventing TNF-α from binding to its receptor in the cell.Infliximab is an artificial antibody. It was originally developed in mice as a mouse antibody. Because humans have immune reactions to mouse proteins, the mouse common domains were replaced with similar human antibody domains. They are monoclonal antibodies and have identical structures and affinities to the target. Because they are a combination of mouse and human antibody amino acid sequences, they are called a "chimeric monoclonal antibody".In the United States, Infliximab can cost $19,000 to $22,000 a year per patient wholesale, according to Centocor.Other monoclonal antibodies targeting TNF-α are golimumab (Simponi), adalimumab (Humira), and certolizumab pegol (Cimzia). Etanercept also binds and inhibits the action of TNF-α, but is not a monoclonal antibody (it is instead a fusion of TNF-receptor and an antibody constant region).Infliximab is administered by intravenous infusion, typically at six- to eight-week intervals, at a clinic or hospital. It cannot be administered orally because the digestive system would destroy the drug.".
- Infliximab atcPrefix "L04".
- Infliximab atcSuffix "AB02".
- Infliximab bioavailability "92.0".
- Infliximab casNumber "170277-31-3".
- Infliximab drugbank "DB00065".
- Infliximab fdaUniiCode "B72HH48FLU".
- Infliximab thumbnail Infliximab_structure2.jpg?width=300.
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- Infliximab wikiPageExternalLink www.remicade.com.
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- Infliximab wikiPageWikiLink Category:Engineered_proteins.
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- Infliximab wikiPageWikiLink Category:Monoclonal_antibodies.
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- Infliximab wikiPageWikiLink Category:TNF_inhibitors.
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- Infliximab wikiPageWikiLink Etanercept.
- Infliximab wikiPageWikiLink European_Medicines_Agency.
- Infliximab wikiPageWikiLink European_Union.
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- Infliximab wikiPageWikiLink Food_and_Drug_Administration_(United_States).
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- Infliximab wikiPageWikiLink George_Kollias_(biologist).
- Infliximab wikiPageWikiLink Golimumab.
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- Infliximab wikiPageWikiLink Leukocyte.
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- Infliximab wikiPageWikiLink Ligand_(biochemistry).
- Infliximab wikiPageWikiLink List_of_autoimmune_diseases.
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- Infliximab wikiPageWikiLink Lysing.
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- Infliximab wikiPageWikiLink Merck_&_Co.
- Infliximab wikiPageWikiLink Merck_&_Co..
- Infliximab wikiPageWikiLink Methotrexate.
- Infliximab wikiPageWikiLink Mitsubishi_Tanabe_Pharma.
- Infliximab wikiPageWikiLink Monoclonal_antibody.
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- Infliximab wikiPageWikiLink New_York_University_School_of_Medicine.
- Infliximab wikiPageWikiLink Pancytopenia.
- Infliximab wikiPageWikiLink Phenotype.