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- Indel abstract "Indel is a molecular biology term for the insertion or the deletion of bases in the DNA of an organism. It has slightly different definitions between its use in evolutionary studies and its use in germ-line and somatic mutation studies.In evolutionary studies, indel is used to mean an insertion or a deletion and indels simply refers to the mutation class that includes both insertions, deletions, and the combination thereof, including insertion and deletion events that may be separated by many years, and may not be related to each other in any way.In germline and somatic mutation studies, indel describes a special mutation class, defined as a mutation resulting in both an insertion of nucleotides and a deletion of nucleotides which results in a net change in the total number of nucleotides, where both changes are nearby on the DNA. A microindel is defined as an indel that results in a net change of 1 to 50 nucleotides.In coding regions of the genome, unless the length of an indel is a multiple of 3, it will produce a frameshift mutation. For example, a common microindel which results in a frameshift causes Bloom syndrome in the Japanese population. Indels can be contrasted with a point mutation. An indel inserts and deletes nucleotides from a sequence, while a point mutation is a form of substitution that replaces one of the nucleotides without changing the overall number in the DNA. Indels can also be contrasted with Tandem Base Mutations (TBM), which may result from fundamentally different mechanisms. A TBM is defined as a substitution at adjacent nucleotides (primarily substitutions at two adjacent nucleotides, but substitutions at three adjacent nucleotides have been observed."Indels", as defined as either an insertion or deletion, can be used as genetic markers in natural populations, especially in phylogenetic studies. It has been shown that genomic regions with multiple indels can also be used for species-identification procedures.An indel change of a single DNA base encoding part of an mRNA results in a "frameshift" when translating the mRNA and perhaps reading on to an inappropriate (premature) stop codon in a different frame. Indels that are not multiples of 3 are particularly uncommon in coding regions but relatively common in non-coding regions. There are approximately 192-280 frameshifting indels in each person. Note, however, the absolute rate of indels in most known genomes, including humans, tends to be markedly lower than base substitutions, except near highly repetitive regions, including homopolymers and microsatellites.The term "indel" has been co-opted in recent years by genome scientists for use in the sense described above. This is a change from its original use and meaning, which arose from systematics. In systematics, researchers could find differences between sequences, such as from two different species. But it was impossible to infer if one species lost the sequence or the other species gained it. For example, species A has a run of 4 G nucleotides at a locus and species B has 5 G's at the same locus. If the mode of selection is unknown, one can not tell if species A lost one G (a "deletion" event") or species B gained one G (an "insertion" event). When one cannot infer the phylogenetic direction of the sequence change, the sequence change event is referred to as an "indel".".
- Indel wikiPageID "1944711".
- Indel wikiPageLength "9629".
- Indel wikiPageOutDegree "22".
- Indel wikiPageRevisionID "673287931".
- Indel wikiPageWikiLink Bloom_syndrome.
- Indel wikiPageWikiLink Category:Genetics.
- Indel wikiPageWikiLink Category:Molecular_biology.
- Indel wikiPageWikiLink Category:Mutation.
- Indel wikiPageWikiLink Coding_region.
- Indel wikiPageWikiLink Deletion_(genetics).
- Indel wikiPageWikiLink Frameshift_mutation.
- Indel wikiPageWikiLink Guanine.
- Indel wikiPageWikiLink Insertion_(genetics).
- Indel wikiPageWikiLink MRNA.
- Indel wikiPageWikiLink Messenger_RNA.
- Indel wikiPageWikiLink Microsatellite.
- Indel wikiPageWikiLink Microsatellite_(genetics).
- Indel wikiPageWikiLink Nucleobase.
- Indel wikiPageWikiLink Nucleotide.
- Indel wikiPageWikiLink Nucleotides.
- Indel wikiPageWikiLink Phylogenetic.
- Indel wikiPageWikiLink Phylogenetics.
- Indel wikiPageWikiLink Phylogeny.
- Indel wikiPageWikiLink Point_mutation.
- Indel wikiPageWikiLink Polymer.
- Indel wikiPageWikiLink Science.
- Indel wikiPageWikiLink Stop_codon.
- Indel wikiPageWikiLink Systematics.
- Indel wikiPageWikiLinkText "Indel".
- Indel wikiPageWikiLinkText "deletion".
- Indel wikiPageWikiLinkText "indel mutation".
- Indel wikiPageWikiLinkText "indel".
- Indel wikiPageWikiLinkText "insertion and deletion events".
- Indel wikiPageWikiLinkText "insertion".
- Indel wikiPageWikiLinkText "insertions and deletions".
- Indel wikiPageWikiLinkText "insertions/deletions".
- Indel hasPhotoCollection Indel.
- Indel wikiPageUsesTemplate Template:Citation_needed.
- Indel wikiPageUsesTemplate Template:For.
- Indel wikiPageUsesTemplate Template:Mutation.
- Indel wikiPageUsesTemplate Template:Reflist.
- Indel subject Category:Genetics.
- Indel subject Category:Molecular_biology.
- Indel subject Category:Mutation.
- Indel hypernym Term.
- Indel type Article.
- Indel type Article.
- Indel comment "Indel is a molecular biology term for the insertion or the deletion of bases in the DNA of an organism.".
- Indel label "Indel".
- Indel sameAs Indel.
- Indel sameAs Indel.
- Indel sameAs Indel.
- Indel sameAs Indel.
- Indel sameAs Indel.
- Indel sameAs Indel.
- Indel sameAs m.067_hq.
- Indel sameAs Q1576681.
- Indel sameAs Q1576681.
- Indel wasDerivedFrom Indel?oldid=673287931.
- Indel isPrimaryTopicOf Indel.