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- Incretin abstract "Incretins are a group of metabolic hormones that stimulate a decrease in blood glucose levels. Incretins do so by causing an increase in the amount of insulin released from pancreatic beta cells of the islets of Langerhans after eating, before blood glucose levels become elevated. They also slow the rate of absorption of nutrients into the blood stream by reducing gastric emptying and may directly reduce food intake. As expected, they also inhibit glucagon release from the alpha cells of the islets of Langerhans. The two main candidate molecules that fulfill criteria for an incretin are the intestinal peptides glucagon-like peptide-1 (GLP-1) and gastric inhibitory peptide (also known as: glucose-dependent insulinotropic polypeptide or GIP). Both GLP-1 and GIP are rapidly inactivated by the enzyme dipeptidyl peptidase-4 (DPP-4); both GLP-1 and GIP are members of the glucagon peptide superfamily."Many factors stimulate insulin secretion, but the main one is blood glucose. Incretins, especially GIP and GLP-1 secreted, respectively, by K and L cells in the gut are also important", (Rang and Dale's Pharmacology (2015)).GLP-1 (7-36) amide is not very useful for treatment of type 2 diabetes mellitus, since it must be administered by continuous subcutaneous infusion. Several long-lasting analogs having insulinotropic activity have been developed, and three, exenatide (Byetta) and liraglutide (Victoza), plus exenatide extended-release (Bydureon), have been approved for use in the U.S. The main disadvantage of these GLP-1 analogs is they must be administered by subcutaneous injection.Another approach is to inhibit the enzyme that inactivates GLP-1 and GIP, DPP-4. Several DPP-4 inhibitors that can be taken orally as tablets have been developed.".
- Incretin thumbnail Incretins_and_DPP_4_inhibitors.svg?width=300.
- Incretin wikiPageID "1549790".
- Incretin wikiPageLength "4984".
- Incretin wikiPageOutDegree "29".
- Incretin wikiPageRevisionID "665248208".
- Incretin wikiPageWikiLink Albiglutide.
- Incretin wikiPageWikiLink Alpha_cell.
- Incretin wikiPageWikiLink Alpha_cells.
- Incretin wikiPageWikiLink Anglerfish.
- Incretin wikiPageWikiLink Beta_cell.
- Incretin wikiPageWikiLink Beta_cells.
- Incretin wikiPageWikiLink Blood_glucose.
- Incretin wikiPageWikiLink Blood_sugar.
- Incretin wikiPageWikiLink Category:Gastric_hormones.
- Incretin wikiPageWikiLink Category:Intestinal_hormones.
- Incretin wikiPageWikiLink Category:Peptide_hormones.
- Incretin wikiPageWikiLink DPP-4_inhibitors.
- Incretin wikiPageWikiLink Diabetes_mellitus_type_2.
- Incretin wikiPageWikiLink Dipeptidyl_peptidase-4.
- Incretin wikiPageWikiLink Dipeptidyl_peptidase-4_inhibitor.
- Incretin wikiPageWikiLink Exenatide.
- Incretin wikiPageWikiLink Gastric_inhibitory_peptide.
- Incretin wikiPageWikiLink Gastric_inhibitory_polypeptide.
- Incretin wikiPageWikiLink Glucagon.
- Incretin wikiPageWikiLink Glucagon-like_peptide-1.
- Incretin wikiPageWikiLink Glucagon-like_peptide-1_agonist.
- Incretin wikiPageWikiLink Glucagon-like_peptide-1_analog.
- Incretin wikiPageWikiLink Hormone.
- Incretin wikiPageWikiLink Insulin.
- Incretin wikiPageWikiLink Islets_of_Langerhans.
- Incretin wikiPageWikiLink Liraglutide.
- Incretin wikiPageWikiLink Metabolic.
- Incretin wikiPageWikiLink Metabolism.
- Incretin wikiPageWikiLink Pancreatic_islets.
- Incretin wikiPageWikiLink Peptide.
- Incretin wikiPageWikiLink Proglucagon.
- Incretin wikiPageWikiLink Secretin.
- Incretin wikiPageWikiLink Type_2_diabetes_mellitus.
- Incretin wikiPageWikiLink File:Incretins_and_DPP_4_inhibitors.svg.
- Incretin wikiPageWikiLinkText "Incretin".
- Incretin wikiPageWikiLinkText "incretin".
- Incretin hasPhotoCollection Incretin.
- Incretin wikiPageUsesTemplate Template:Citation_needed.
- Incretin wikiPageUsesTemplate Template:Reflist.
- Incretin subject Category:Gastric_hormones.
- Incretin subject Category:Intestinal_hormones.
- Incretin subject Category:Peptide_hormones.
- Incretin hypernym Group.
- Incretin type Band.
- Incretin type Hormone.
- Incretin type Peptide.
- Incretin comment "Incretins are a group of metabolic hormones that stimulate a decrease in blood glucose levels. Incretins do so by causing an increase in the amount of insulin released from pancreatic beta cells of the islets of Langerhans after eating, before blood glucose levels become elevated. They also slow the rate of absorption of nutrients into the blood stream by reducing gastric emptying and may directly reduce food intake.".
- Incretin label "Incretin".
- Incretin sameAs إنكرتين.
- Incretin sameAs Incretina.
- Incretin sameAs Inkretin.
- Incretin sameAs Inkretin-Effekt.
- Incretin sameAs Incretina.
- Incretin sameAs اینکرتین.
- Incretin sameAs Incrétine.
- Incretin sameAs Incretina.
- Incretin sameAs Inkretin.
- Incretin sameAs Inkretin.
- Incretin sameAs Incretine.
- Incretin sameAs インクレチン.
- Incretin sameAs Incretine.
- Incretin sameAs Inkretiner.
- Incretin sameAs Inkretyny.
- Incretin sameAs Incretina.
- Incretin sameAs m.059l_v.
- Incretin sameAs இன்கிரெடின்.
- Incretin sameAs Q1420402.
- Incretin sameAs Q1420402.
- Incretin wasDerivedFrom Incretin?oldid=665248208.
- Incretin depiction Incretins_and_DPP_4_inhibitors.svg.
- Incretin isPrimaryTopicOf Incretin.