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- IdMOC abstract "Integrated discrete Multiple Organ Culture (IdMOC) is an in vitro, cell culture based experimental model for the study of intercellular communication. In conventional in vitro systems, each cell type is studied in isolation ignoring critical interactions between organs or cell types. IdMOC technology is based on the concept that multiple organs signal or communicate via the systemic circulation (i.e., blood).The IdMOC plate consists of multiple inner wells within a large interconnecting chamber. Multiple cell types are first individually seeded in the inner wells and, when required, are flooded with an overlying medium to facilitate well-to-well communication. Test material can be added to the overlying medium and both media and cells can be analyzed individually. Plating of hepatocytes with other organ-specific cells allows evaluation of drug metabolism and organotoxicity.The IdMOC system has numerous applications in drug development, such as the evaluation of drug metabolism and toxicity. It can simultaneously evaluate the toxic potential of a drug on cells from multiple organs and evaluate drug stability, distribution, metabolite formation, and efficacy. By modeling multiple-organ interactions, IdMOC can examine the pharmacological effects of a drug and its metabolites on target and off-target organs as well as evaluate drug-drug interactions by measuring cytochrome P450 (CYP) induction or inhibition in hepatocytes.IdMOC can also be used for routine and high throughput screening of drugs with desirable ADME or ADME-Tox properties. In vitro toxicity screening using hepatocytes in conjunction with other primary cells such as cardiomyocytes (cardiotoxicity model), kidney proximal tubule epithelial cells (nephrotoxicity model), astrocytes (neurotoxicity model), endothelial cells (vascular toxicity model), and airway epithelial cells (pulmonary toxicity model) is invaluable to the drug design and discovery process.The IdMOC was patented by Dr. Albert P. Li in 2004.".
- IdMOC thumbnail IdMOC.JPG?width=300.
- IdMOC wikiPageExternalLink 7512703.cms?.
- IdMOC wikiPageExternalLink www.apsciences.com.
- IdMOC wikiPageExternalLink www.invitroadmet.com.
- IdMOC wikiPageID "14350461".
- IdMOC wikiPageLength "3805".
- IdMOC wikiPageOutDegree "31".
- IdMOC wikiPageRevisionID "678137077".
- IdMOC wikiPageWikiLink ADME.
- IdMOC wikiPageWikiLink ADME-Tox.
- IdMOC wikiPageWikiLink Cardiotoxicity.
- IdMOC wikiPageWikiLink Category:Biochemistry.
- IdMOC wikiPageWikiLink Category:Cell_communication.
- IdMOC wikiPageWikiLink Category:Metabolism.
- IdMOC wikiPageWikiLink Category:Pharmaceutical_industry.
- IdMOC wikiPageWikiLink Category:Pharmaceutics.
- IdMOC wikiPageWikiLink Category:Pharmacodynamics.
- IdMOC wikiPageWikiLink Category:Pharmacokinetics.
- IdMOC wikiPageWikiLink Cell_signaling.
- IdMOC wikiPageWikiLink Cytochrome_P450.
- IdMOC wikiPageWikiLink Drug_design.
- IdMOC wikiPageWikiLink Drug_development.
- IdMOC wikiPageWikiLink Drug_discovery.
- IdMOC wikiPageWikiLink Drug_interaction.
- IdMOC wikiPageWikiLink Drug_interactions.
- IdMOC wikiPageWikiLink Drug_metabolism.
- IdMOC wikiPageWikiLink Hepatocyte.
- IdMOC wikiPageWikiLink Hepatocytes.
- IdMOC wikiPageWikiLink High-throughput_screening.
- IdMOC wikiPageWikiLink High_throughput_screening.
- IdMOC wikiPageWikiLink In_vitro_toxicology.
- IdMOC wikiPageWikiLink Intercellular_communication.
- IdMOC wikiPageWikiLink Nephrotoxicity.
- IdMOC wikiPageWikiLink Neurotoxicity.
- IdMOC wikiPageWikiLink Pharmacology.
- IdMOC wikiPageWikiLink Pulmonary_toxicity.
- IdMOC wikiPageWikiLink Toxicity.
- IdMOC wikiPageWikiLink Toxicology.
- IdMOC wikiPageWikiLink File:IdMOC.JPG.
- IdMOC hasPhotoCollection IdMOC.
- IdMOC wikiPageUsesTemplate Template:Orphan.
- IdMOC wikiPageUsesTemplate Template:Reflist.
- IdMOC subject Category:Biochemistry.
- IdMOC subject Category:Cell_communication.
- IdMOC subject Category:Metabolism.
- IdMOC subject Category:Pharmaceutical_industry.
- IdMOC subject Category:Pharmaceutics.
- IdMOC subject Category:Pharmacodynamics.
- IdMOC subject Category:Pharmacokinetics.
- IdMOC type Article.
- IdMOC type Drug.
- IdMOC type Article.
- IdMOC type Drug.
- IdMOC type Pharmaceutic.
- IdMOC type Process.
- IdMOC type Science.
- IdMOC comment "Integrated discrete Multiple Organ Culture (IdMOC) is an in vitro, cell culture based experimental model for the study of intercellular communication. In conventional in vitro systems, each cell type is studied in isolation ignoring critical interactions between organs or cell types.".
- IdMOC label "IdMOC".
- IdMOC sameAs m.03d1b8n.
- IdMOC sameAs Q5986853.
- IdMOC sameAs Q5986853.
- IdMOC wasDerivedFrom IdMOC?oldid=678137077.
- IdMOC depiction IdMOC.JPG.
- IdMOC isPrimaryTopicOf IdMOC.