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- IMD_domain abstract "In molecular biology, the IMD domain (IRSp53 and MIM (missing in metastases) homology Domain) is a BAR-like domain of approximately 250 amino acids found at the N-terminus in the insulin receptor tyrosine kinase substrate p53 (IRSp53/BAIAP2) and in the evolutionarily related IRSp53/MIM (MTSS1) family. In IRSp53, a ubiquitous regulator of the actin cytoskeleton, the IMD domain acts as conserved F-actin bundling domain involved in filopodium formation. Filopodium-inducing IMD activity is regulated by Cdc42 and Rac1 (Rho-family GTPases) and is SH3-independent. The IRSp53/MIM family is a novel F-actin bundling protein family that includes invertebrate relatives: Vertebrate MIM (missing in metastasis) (MTSS1), an actin-binding scaffold protein that may be involved in cancer metastasis. Vertebrate ABBA-1 (MTSS1L), a MIM-related protein. Vertebrate brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1-associated protein 2) or insulin receptor tyrosine kinase substrate p53 (IRSp53), a multifunctional adaptor protein that links Rac1 with a Wiskott-Aldrich syndrome family verprolin-homologous protein 2 (WAVE2/WASF2) to induce lamellipodia or Cdc42 with Mena to induce filopodia. Vertebrate brain-specific angiogenesis nhibitor 1-associated protein 2-like proteins 1 and 2 (BAI1-associated protein 2-like proteins 1 and 2, BAIAP2L1 and BAIAP2L2). Drosophila melanogaster (Fruit fly) CG32082-PA. Caenorhabditis elegans M04F3.5 protein. The vertebrate IRSp53/MIM family is divided into two major groups: the IRSp53 subfamily and the MIM/ABBA subfamily. The putative invertebrate homologues are positioned between them. The IRSp53 subfamily members contain an SH3 domain, and the MIM/ABBA subfamily proteins contain a WH2 (WASP-homology 2) domain. The vertebrate SH3-containing subfamily is further divided into three groups according to the presence or absence of the WWB and the half-CRIB motif. The IMD domain can bind to and bundle actin filaments, bind to membranes and interact with the small GTPase Rac.The IMD domain folds as a coiled coil of three extended alpha-helices and a shorter C-terminal helix. Helix 4 packs tightly against the other three helices, and thus represents an integral part of the domain. The fold of the IMD domain closely resembles that of the BAR (Bin-Amphiphysin-RVS) domain, a functional module serving both as a sensor and inducer of membrane curvature. The WH2 domain performs a scaffolding function.".
- IMD_domain symbol "IMD".
- IMD_domain thumbnail PDB_1wdz_EBI.jpg?width=300.
- IMD_domain wikiPageID "34122040".
- IMD_domain wikiPageLength "6440".
- IMD_domain wikiPageOutDegree "51".
- IMD_domain wikiPageRevisionID "591775869".
- IMD_domain wikiPageWikiLink Actin.
- IMD_domain wikiPageWikiLink Adaptor_protein.
- IMD_domain wikiPageWikiLink Alpha_helix.
- IMD_domain wikiPageWikiLink Amino_acid.
- IMD_domain wikiPageWikiLink BAIAP2.
- IMD_domain wikiPageWikiLink BAIAP2L1.
- IMD_domain wikiPageWikiLink BAIAP2L2.
- IMD_domain wikiPageWikiLink BAR_domain.
- IMD_domain wikiPageWikiLink Biological_membrane.
- IMD_domain wikiPageWikiLink C-terminal.
- IMD_domain wikiPageWikiLink C-terminus.
- IMD_domain wikiPageWikiLink CDC42.
- IMD_domain wikiPageWikiLink Caenorhabditis_elegans.
- IMD_domain wikiPageWikiLink Cancer.
- IMD_domain wikiPageWikiLink Category:Protein_families.
- IMD_domain wikiPageWikiLink Cdc42.
- IMD_domain wikiPageWikiLink Coiled_coil.
- IMD_domain wikiPageWikiLink Cytoskeleton.
- IMD_domain wikiPageWikiLink Drosophila_melanogaster.
- IMD_domain wikiPageWikiLink Vasp_homology_proteins.
- IMD_domain wikiPageWikiLink Evolution.
- IMD_domain wikiPageWikiLink Evolutionary.
- IMD_domain wikiPageWikiLink F-actin.
- IMD_domain wikiPageWikiLink Filopodia.
- IMD_domain wikiPageWikiLink Filopodium.
- IMD_domain wikiPageWikiLink Homology_(biology).
- IMD_domain wikiPageWikiLink Invertebrate.
- IMD_domain wikiPageWikiLink Lamellipodia.
- IMD_domain wikiPageWikiLink Lamellipodium.
- IMD_domain wikiPageWikiLink MTSS1.
- IMD_domain wikiPageWikiLink MTSS1L.
- IMD_domain wikiPageWikiLink Metastases.
- IMD_domain wikiPageWikiLink Metastasis.
- IMD_domain wikiPageWikiLink N-terminus.
- IMD_domain wikiPageWikiLink Omnipresence.
- IMD_domain wikiPageWikiLink Protein.
- IMD_domain wikiPageWikiLink Protein-protein_interaction.
- IMD_domain wikiPageWikiLink Protein_domain.
- IMD_domain wikiPageWikiLink Protein_family.
- IMD_domain wikiPageWikiLink Protein_folding.
- IMD_domain wikiPageWikiLink Protein_motif.
- IMD_domain wikiPageWikiLink Protein–protein_interaction.
- IMD_domain wikiPageWikiLink RAC1.
- IMD_domain wikiPageWikiLink Rac1.
- IMD_domain wikiPageWikiLink Rac_(GTPase).
- IMD_domain wikiPageWikiLink SH3_domain.
- IMD_domain wikiPageWikiLink Scaffold_protein.
- IMD_domain wikiPageWikiLink Sensor.
- IMD_domain wikiPageWikiLink Signal_transducing_adaptor_protein.
- IMD_domain wikiPageWikiLink Structural_motif.
- IMD_domain wikiPageWikiLink Ubiquitous.
- IMD_domain wikiPageWikiLink Vertebrate.
- IMD_domain wikiPageWikiLink WASF2.
- IMD_domain wikiPageWikiLink WH2_motif.
- IMD_domain wikiPageWikiLink Wiskott-Aldrich_syndrome.
- IMD_domain wikiPageWikiLink Wiskott–Aldrich_syndrome.
- IMD_domain caption "crystal structure of rcb domain of irsp53".
- IMD_domain hasPhotoCollection IMD_domain.
- IMD_domain interpro "IPR013606".
- IMD_domain name "IRSp53/MIM homology domain".
- IMD_domain pfam "PF08397".
- IMD_domain pfamClan "CL0145".
- IMD_domain symbol "IMD".
- IMD_domain wikiPageUsesTemplate Template:Infobox_protein_family.
- IMD_domain wikiPageUsesTemplate Template:InterPro_content.
- IMD_domain wikiPageUsesTemplate Template:Reflist.
- IMD_domain subject Category:Protein_families.
- IMD_domain hypernym Domain.
- IMD_domain type Biomolecule.
- IMD_domain type Protein.
- IMD_domain type Chemical.
- IMD_domain type Thing.
- IMD_domain type Q206229.
- IMD_domain type Q8054.
- IMD_domain comment "In molecular biology, the IMD domain (IRSp53 and MIM (missing in metastases) homology Domain) is a BAR-like domain of approximately 250 amino acids found at the N-terminus in the insulin receptor tyrosine kinase substrate p53 (IRSp53/BAIAP2) and in the evolutionarily related IRSp53/MIM (MTSS1) family. In IRSp53, a ubiquitous regulator of the actin cytoskeleton, the IMD domain acts as conserved F-actin bundling domain involved in filopodium formation.".
- IMD_domain label "IMD domain".
- IMD_domain sameAs m.0hr0ryl.
- IMD_domain sameAs Q5971987.
- IMD_domain sameAs Q5971987.
- IMD_domain wasDerivedFrom IMD_domain?oldid=591775869.
- IMD_domain depiction PDB_1wdz_EBI.jpg.
- IMD_domain isPrimaryTopicOf IMD_domain.