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- I-CreI abstract "I-CreI is a homing endonuclease whose gene was first discovered in the chloroplast genome of Chlamydomonas reinhardtii, a species of unicellular green algae. It is named for the facts that: it resides in an Intron; it was isolated from Clamydomonas reinhardtii; it was the first (I) such gene isolated from C. reinhardtii. Its gene resides in a group I intron in the 23S ribosomal RNA gene of the C. reinhardtii chloroplast, and I-CreI is only expressed when its mRNA is spliced from the primary transcript of the 23S gene. I-CreI enzyme, which functions as a homodimer, recognizes a 22-nucleotide sequence of duplex DNA and cleaves one phosphodiester bond on each strand at specific positions. I-CreI is a member of the LAGLIDADG family of homing endonucleases, all of which have a conserved LAGLIDADG amino acid motif that contributes to their associative domains and active sites. When the I-CreI-containing intron encounters a 23S gene lacking the intron, I-CreI enzyme "homes" in on the "intron-minus" allele of 23S and effects its parent intron's insertion into the intron-minus allele. Introns with this behavior are called mobile introns. Because I-CreI provides for its own propagation while conferring no benefit on its host, it is an example of selfish DNA.".
- I-CreI wikiPageID "8142925".
- I-CreI wikiPageLength "11512".
- I-CreI wikiPageOutDegree "37".
- I-CreI wikiPageRevisionID "678944936".
- I-CreI wikiPageWikiLink Allele.
- I-CreI wikiPageWikiLink Category:Biotechnology.
- I-CreI wikiPageWikiLink Category:Molecular_biology.
- I-CreI wikiPageWikiLink Category:Restriction_enzymes.
- I-CreI wikiPageWikiLink Chlamydomonas_reinhardtii.
- I-CreI wikiPageWikiLink Chloroplast.
- I-CreI wikiPageWikiLink DNA_repair.
- I-CreI wikiPageWikiLink Drosophila_melanogaster.
- I-CreI wikiPageWikiLink Enzyme.
- I-CreI wikiPageWikiLink Escherichia_coli.
- I-CreI wikiPageWikiLink Eukaryote.
- I-CreI wikiPageWikiLink File:Cre_crystal_structure.png.
- I-CreI wikiPageWikiLink Gene.
- I-CreI wikiPageWikiLink Gene_therapy.
- I-CreI wikiPageWikiLink Genome.
- I-CreI wikiPageWikiLink Green_algae.
- I-CreI wikiPageWikiLink Homing_endonuclease.
- I-CreI wikiPageWikiLink Homodimer.
- I-CreI wikiPageWikiLink Homologous_recombination.
- I-CreI wikiPageWikiLink Intron.
- I-CreI wikiPageWikiLink MRNA.
- I-CreI wikiPageWikiLink Messenger_RNA.
- I-CreI wikiPageWikiLink Mobile_introns.
- I-CreI wikiPageWikiLink Model_organism.
- I-CreI wikiPageWikiLink Non-coding_RNA.
- I-CreI wikiPageWikiLink Protein_dimer.
- I-CreI wikiPageWikiLink RNA_gene.
- I-CreI wikiPageWikiLink RRNA.
- I-CreI wikiPageWikiLink Restriction_endonucleases.
- I-CreI wikiPageWikiLink Restriction_enzyme.
- I-CreI wikiPageWikiLink Ribosomal_RNA.
- I-CreI wikiPageWikiLink Ribosome.
- I-CreI wikiPageWikiLink Saccharomyces_cerevisiae.
- I-CreI wikiPageWikiLink Selfish_DNA.
- I-CreI wikiPageWikiLink Transcription_(genetics).
- I-CreI wikiPageWikiLinkText "I-CreI homing endonuclease".
- I-CreI wikiPageWikiLinkText "I-CreI".
- I-CreI hasPhotoCollection I-CreI.
- I-CreI wikiPageUsesTemplate Template:Reflist.
- I-CreI subject Category:Biotechnology.
- I-CreI subject Category:Molecular_biology.
- I-CreI subject Category:Restriction_enzymes.
- I-CreI hypernym Endonuclease.
- I-CreI type Protein.
- I-CreI comment "I-CreI is a homing endonuclease whose gene was first discovered in the chloroplast genome of Chlamydomonas reinhardtii, a species of unicellular green algae. It is named for the facts that: it resides in an Intron; it was isolated from Clamydomonas reinhardtii; it was the first (I) such gene isolated from C. reinhardtii. Its gene resides in a group I intron in the 23S ribosomal RNA gene of the C.".
- I-CreI label "I-CreI".
- I-CreI sameAs m.026t4wv.
- I-CreI sameAs Q5967611.
- I-CreI sameAs Q5967611.
- I-CreI wasDerivedFrom I-CreI?oldid=678944936.
- I-CreI isPrimaryTopicOf I-CreI.