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- Hyperphosphorylation abstract "Hyperphosphorylation occurs when a biochemical with multiple phosphorylation sites is fully saturated. Hyperphosphorylation is one of the signalling mechanisms used by the cell to regulate mitosis. When these mechanisms fail, developmental problems or cancer are a likely outcome. The mechanism appears to be largely conserved throughout eukaryote species. The dynamics of mitosis are similar to a state machine. In a healthy cell, checkpoints between phases, permit a new phase to begin only when the previous phase is complete and successful. At these checkpoints, gatekeeper molecules block or allow events, depending on their level of phosphorylation. Kinases are responsible for adding phosphate groups and phosphatases for removing them. Cyclins are molecules that manage the timing of cell cycle events. Cyclin dependent kinases pair up with cyclins to become operational. Cyclins are named because they are created or destroyed at predetermined points within the cell cycle. Kinase inhibitors add another level of modulation. Kinase inhibitors are grouped into classes and are assigned not very descriptive acronyms. These include INKS for inhibitors of kinase, KIPS for kinase inhibitors and CKIPS for cyclin dependent kinases inhibitors. Scientists have used a variety of tools to unravel the role of hyperphosphorylation. These include the study of knockout genes, the use of antibodies to block receptors on particular molecules, the use of temperature sensitive mutants, and microarrays to monitor the expression of particular genes. Yeast are a popular species for study because of the rapid cell cycle. Rb is one of the most studied checkpoint molecules. It is so named because defects in Rb are linked to retinoblastoma. In its unphosphorylated state it blocks the transition from G0 or resting state to S or synthesis. It does this in at least 3 ways. It inhibits RNA synthesis, it prevents chromosomes from unwinding and it binds E2F, a factor needed for DNA synthesis. When it is hyperphosphorylated, Rb becomes inactive, releasing bound E2F and allowing phase S to proceed. Wee is a protein that operates at the G2 to metaphase checkpoint. Wee becomes active if errors occur in the DNA synthesis phase. It blocks entry into metaphase until the problem is resolved. Like Rb, wee becomes inactive when hyperphosphorylated. In contrast Mad1 is active when hyperphosphorylated. In its active state it is part of the checkpoint that blocks transition to anaphase. Cdc2, part of the metaphase entry checkpoint, is active depending on the pattern of phosphorylation.".
- Hyperphosphorylation wikiPageID "1617243".
- Hyperphosphorylation wikiPageLength "2980".
- Hyperphosphorylation wikiPageOutDegree "23".
- Hyperphosphorylation wikiPageRevisionID "332005318".
- Hyperphosphorylation wikiPageWikiLink Cancer.
- Hyperphosphorylation wikiPageWikiLink Category:Cell_biology.
- Hyperphosphorylation wikiPageWikiLink Category:Cell_cycle.
- Hyperphosphorylation wikiPageWikiLink Category:Phosphorus.
- Hyperphosphorylation wikiPageWikiLink Category:Posttranslational_modification.
- Hyperphosphorylation wikiPageWikiLink Category:Signal_transduction.
- Hyperphosphorylation wikiPageWikiLink Cdc2.
- Hyperphosphorylation wikiPageWikiLink Cell_(biology).
- Hyperphosphorylation wikiPageWikiLink Cyclin.
- Hyperphosphorylation wikiPageWikiLink Cyclin-dependent_kinase_1.
- Hyperphosphorylation wikiPageWikiLink Enzyme_inhibitor.
- Hyperphosphorylation wikiPageWikiLink Eukaryote.
- Hyperphosphorylation wikiPageWikiLink Kinase.
- Hyperphosphorylation wikiPageWikiLink Kinases.
- Hyperphosphorylation wikiPageWikiLink Mad1.
- Hyperphosphorylation wikiPageWikiLink Microarray.
- Hyperphosphorylation wikiPageWikiLink Mitosis.
- Hyperphosphorylation wikiPageWikiLink Phosphatase.
- Hyperphosphorylation wikiPageWikiLink Phosphatases.
- Hyperphosphorylation wikiPageWikiLink Phosphate.
- Hyperphosphorylation wikiPageWikiLink Phosphate_group.
- Hyperphosphorylation wikiPageWikiLink Phosphorylation.
- Hyperphosphorylation wikiPageWikiLink Protein.
- Hyperphosphorylation wikiPageWikiLink Retinoblastoma.
- Hyperphosphorylation wikiPageWikiLink Retinoblastoma_protein.
- Hyperphosphorylation wikiPageWikiLink Wee1.
- Hyperphosphorylation wikiPageWikiLink Wee_(cell_cycle).
- Hyperphosphorylation wikiPageWikiLink Yeast.
- Hyperphosphorylation wikiPageWikiLinkText "Hyperphosphorylation".
- Hyperphosphorylation wikiPageWikiLinkText "hyperphosphorylated".
- Hyperphosphorylation wikiPageWikiLinkText "hyperphosphorylation".
- Hyperphosphorylation wikiPageWikiLinkText "the pathogenic form".
- Hyperphosphorylation hasPhotoCollection Hyperphosphorylation.
- Hyperphosphorylation wikiPageUsesTemplate Template:Protein_posttranslational_modification.
- Hyperphosphorylation wikiPageUsesTemplate Template:Unreferenced.
- Hyperphosphorylation subject Category:Cell_biology.
- Hyperphosphorylation subject Category:Cell_cycle.
- Hyperphosphorylation subject Category:Phosphorus.
- Hyperphosphorylation subject Category:Posttranslational_modification.
- Hyperphosphorylation subject Category:Signal_transduction.
- Hyperphosphorylation type Article.
- Hyperphosphorylation type Article.
- Hyperphosphorylation type Element.
- Hyperphosphorylation type Phosphoru.
- Hyperphosphorylation comment "Hyperphosphorylation occurs when a biochemical with multiple phosphorylation sites is fully saturated. Hyperphosphorylation is one of the signalling mechanisms used by the cell to regulate mitosis. When these mechanisms fail, developmental problems or cancer are a likely outcome. The mechanism appears to be largely conserved throughout eukaryote species. The dynamics of mitosis are similar to a state machine.".
- Hyperphosphorylation label "Hyperphosphorylation".
- Hyperphosphorylation sameAs فرافسفرگیری.
- Hyperphosphorylation sameAs m.05h024.
- Hyperphosphorylation sameAs Q15195154.
- Hyperphosphorylation sameAs Q15195154.
- Hyperphosphorylation wasDerivedFrom Hyperphosphorylation?oldid=332005318.
- Hyperphosphorylation isPrimaryTopicOf Hyperphosphorylation.