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- Human_artificial_chromosome abstract "A human artificial chromosome (HAC) is a microchromosome that can act as a new chromosome in a population of human cells. That is, instead of 46 chromosomes, the cell could have 47 with the 47th being very small, roughly 6-10 megabases (Mb) in size instead of 50-250 Mb for natural chromosomes, and able to carry new genes introduced by human researchers. Ideally, researchers could integrate different genes that perform a variety of functions, including disease defense.Alternative methods of creating transgenes, such as utilizing yeast artificial chromosomes and bacterial artificial chromosomes, lead to unpredictable problems. The genetic material introduced by these vectors not only leads to different expression levels, but the inserts also disrupt the original genome. HACs differ in this regard, as they are entirely separate chromosomes. This separation from existing genetic material assumes that no insertional mutants would arise. This stability and accuracy makes HACs preferable to other methods such as viral vectors, YACs and BACs. HACs allow for delivery of more DNA (including promoters and copy-number variation) than is possible with viral vectors.Yeast artificial chromosomes and bacterial artificial chromosomes were created before human artificial chromosomes, which first appeared in 1997. HACs are useful in expression studies as gene transfer vectors, as a tool for elucidating human chromosome function, and as a method for actively annotating the human genome.".
- Human_artificial_chromosome wikiPageExternalLink how-artificial-chromosomes-could-transform-humanity-754993569.
- Human_artificial_chromosome wikiPageExternalLink duchenne-muscular-dystrophy.
- Human_artificial_chromosome wikiPageExternalLink a605011.html.
- Human_artificial_chromosome wikiPageID "5921769".
- Human_artificial_chromosome wikiPageLength "10619".
- Human_artificial_chromosome wikiPageOutDegree "27".
- Human_artificial_chromosome wikiPageRevisionID "638081094".
- Human_artificial_chromosome wikiPageWikiLink 1997_in_science.
- Human_artificial_chromosome wikiPageWikiLink Bacterial_artificial_chromosome.
- Human_artificial_chromosome wikiPageWikiLink Base_pair.
- Human_artificial_chromosome wikiPageWikiLink Category:Molecular_biology.
- Human_artificial_chromosome wikiPageWikiLink Centromere.
- Human_artificial_chromosome wikiPageWikiLink Chromosome.
- Human_artificial_chromosome wikiPageWikiLink Copy-number_variation.
- Human_artificial_chromosome wikiPageWikiLink Cosmid.
- Human_artificial_chromosome wikiPageWikiLink Cre-Lox_recombination.
- Human_artificial_chromosome wikiPageWikiLink Fosmid.
- Human_artificial_chromosome wikiPageWikiLink Genetically_modified_organism.
- Human_artificial_chromosome wikiPageWikiLink HT1080.
- Human_artificial_chromosome wikiPageWikiLink Human.
- Human_artificial_chromosome wikiPageWikiLink Human_genome.
- Human_artificial_chromosome wikiPageWikiLink Insertional_mutagenesis.
- Human_artificial_chromosome wikiPageWikiLink Microchromosome.
- Human_artificial_chromosome wikiPageWikiLink Minichromosome.
- Human_artificial_chromosome wikiPageWikiLink Plasmid.
- Human_artificial_chromosome wikiPageWikiLink Promoter_(genetics).
- Human_artificial_chromosome wikiPageWikiLink Transgene.
- Human_artificial_chromosome wikiPageWikiLink Vector_(molecular_biology).
- Human_artificial_chromosome wikiPageWikiLink Viral_vector.
- Human_artificial_chromosome wikiPageWikiLink Yeast_artificial_chromosome.
- Human_artificial_chromosome wikiPageWikiLinkText "Human artificial chromosome".
- Human_artificial_chromosome wikiPageWikiLinkText "artificial chromosomes".
- Human_artificial_chromosome wikiPageWikiLinkText "human artificial chromosome".
- Human_artificial_chromosome wikiPageWikiLinkText "human synthetic artificial chromosomes".
- Human_artificial_chromosome hasPhotoCollection Human_artificial_chromosome.
- Human_artificial_chromosome wikiPageUsesTemplate Template:Nucleic_acids.
- Human_artificial_chromosome wikiPageUsesTemplate Template:Reflist.
- Human_artificial_chromosome subject Category:Molecular_biology.
- Human_artificial_chromosome hypernym Microchromosome.
- Human_artificial_chromosome type Article.
- Human_artificial_chromosome type Article.
- Human_artificial_chromosome comment "A human artificial chromosome (HAC) is a microchromosome that can act as a new chromosome in a population of human cells. That is, instead of 46 chromosomes, the cell could have 47 with the 47th being very small, roughly 6-10 megabases (Mb) in size instead of 50-250 Mb for natural chromosomes, and able to carry new genes introduced by human researchers.".
- Human_artificial_chromosome label "Human artificial chromosome".
- Human_artificial_chromosome sameAs Cromosoma_artificial_humà.
- Human_artificial_chromosome sameAs Cromosoma_artificial_humano.
- Human_artificial_chromosome sameAs Chromosome_artificiel_humain.
- Human_artificial_chromosome sameAs Cromosoma_artificial_humano.
- Human_artificial_chromosome sameAs Ludzki_sztuczny_chromosom.
- Human_artificial_chromosome sameAs m.0fdpjy.
- Human_artificial_chromosome sameAs Q2966744.
- Human_artificial_chromosome sameAs Q2966744.
- Human_artificial_chromosome sameAs 人類人工染色體.
- Human_artificial_chromosome wasDerivedFrom Human_artificial_chromosome?oldid=638081094.
- Human_artificial_chromosome isPrimaryTopicOf Human_artificial_chromosome.