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- Horsley–Clarke_apparatus abstract "The Horsley–Clarke apparatus is a device invented in 1908 by British neurosurgeon and scientist Sir Victor A.H. Horsley and his colleague Robert H. Clarke at University College London to allow experimental and surgical intervention in deep-seated structures of the brain in vertebrates.Also called a stereotactic device, the system uses a set of three coordinates (x, y, and z) in an orthogonal frame of reference (cartesian coordinates). In a brain atlas, composed by serial transverse sections of the animal or human brain, each brain structure can be assigned a number of coordinates. In most atlas, the three dimensions are: latero-lateral (x), dorso-ventral (y) and rostro-caudal (z). The mechanical device has head-holding clamps and bars which puts the head of the animal in a fixed position in reference to the coordinate system (the so-called zero or origin). Guide bars in the x, y, and z directions, fitted with high precision vernier scales allow the experimenter to position the point of a probe (an electrode, a cannula, etc.) inside the brain, at the calculated coordinates for the desired structure, through a small trephined hole in the skull. Then, stimulation, lesions, tissue biopsies, infusion or diffusion of chemical substances, etc. can be done to that spot or area, using a minimally invasive approach.The original apparatus was developed for the work with small to medium experimental animals. It was only in 1947 that the first stereotactic devices for human neurosurgery were developed, by the American neurosurgeons Ernest A. Spiegel and Henry T. Wycis, and Swedish neurosurgeon Lars Leksell. Thus, stereotactic surgery of the brain was born. They were initially used for surgical treatment of Parkinson's disease (pallidotomy, or the surgical ablation of small areas of the pallidum, an area in the basal ganglia of the brain, which are implicated in the physiological control of movement), but later found many applications in the surgical treatment of tumors, vascular malformations, aneurysms, and abscesses, as well as in functional neurosurgery, such as epilepsy, chronic pain, and mental health (psychosurgery).".
- Horsley–Clarke_apparatus wikiPageID "1142976".
- Horsley–Clarke_apparatus wikiPageLength "2593".
- Horsley–Clarke_apparatus wikiPageOutDegree "35".
- Horsley–Clarke_apparatus wikiPageRevisionID "551255485".
- Horsley–Clarke_apparatus wikiPageWikiLink Abscess.
- Horsley–Clarke_apparatus wikiPageWikiLink Abscesses.
- Horsley–Clarke_apparatus wikiPageWikiLink Aneurysm.
- Horsley–Clarke_apparatus wikiPageWikiLink Aneurysms.
- Horsley–Clarke_apparatus wikiPageWikiLink Basal_ganglia.
- Horsley–Clarke_apparatus wikiPageWikiLink Biopsy.
- Horsley–Clarke_apparatus wikiPageWikiLink Brain.
- Horsley–Clarke_apparatus wikiPageWikiLink Brain_atlas.
- Horsley–Clarke_apparatus wikiPageWikiLink Cartesian_coordinate_system.
- Horsley–Clarke_apparatus wikiPageWikiLink Cartesian_coordinates.
- Horsley–Clarke_apparatus wikiPageWikiLink Category:History_of_neuroscience.
- Horsley–Clarke_apparatus wikiPageWikiLink Category:Medical_equipment.
- Horsley–Clarke_apparatus wikiPageWikiLink Chronic_pain.
- Horsley–Clarke_apparatus wikiPageWikiLink Coordinate_system.
- Horsley–Clarke_apparatus wikiPageWikiLink Coordinates.
- Horsley–Clarke_apparatus wikiPageWikiLink Epilepsy.
- Horsley–Clarke_apparatus wikiPageWikiLink Ernest_A._Spiegel.
- Horsley–Clarke_apparatus wikiPageWikiLink Frame_of_reference.
- Horsley–Clarke_apparatus wikiPageWikiLink Globus_pallidus.
- Horsley–Clarke_apparatus wikiPageWikiLink Henry_T._Wycis.
- Horsley–Clarke_apparatus wikiPageWikiLink Lars_Leksell.
- Horsley–Clarke_apparatus wikiPageWikiLink Minimally-invasive_procedures.
- Horsley–Clarke_apparatus wikiPageWikiLink Minimally_invasive.
- Horsley–Clarke_apparatus wikiPageWikiLink Neoplasm.
- Horsley–Clarke_apparatus wikiPageWikiLink Neurosurgeon.
- Horsley–Clarke_apparatus wikiPageWikiLink Neurosurgery.
- Horsley–Clarke_apparatus wikiPageWikiLink Orthogonal.
- Horsley–Clarke_apparatus wikiPageWikiLink Orthogonality.
- Horsley–Clarke_apparatus wikiPageWikiLink Pallidotomy.
- Horsley–Clarke_apparatus wikiPageWikiLink Pallidum.
- Horsley–Clarke_apparatus wikiPageWikiLink Parkinsons_disease.
- Horsley–Clarke_apparatus wikiPageWikiLink Psychosurgery.
- Horsley–Clarke_apparatus wikiPageWikiLink Scientist.
- Horsley–Clarke_apparatus wikiPageWikiLink Skull.
- Horsley–Clarke_apparatus wikiPageWikiLink Stereotactic_surgery.
- Horsley–Clarke_apparatus wikiPageWikiLink Trephine.
- Horsley–Clarke_apparatus wikiPageWikiLink Tumors.
- Horsley–Clarke_apparatus wikiPageWikiLink University_College_London.
- Horsley–Clarke_apparatus wikiPageWikiLink Vascular_malformation.
- Horsley–Clarke_apparatus wikiPageWikiLink Vernier_scale.
- Horsley–Clarke_apparatus wikiPageWikiLink Vertebrate.
- Horsley–Clarke_apparatus wikiPageWikiLink Victor_Horsley.
- Horsley–Clarke_apparatus wikiPageWikiLinkText "Horsley–Clarke apparatus".
- Horsley–Clarke_apparatus wikiPageWikiLinkText "stereotactic method".
- Horsley–Clarke_apparatus hasPhotoCollection Horsley–Clarke_apparatus.
- Horsley–Clarke_apparatus wikiPageUsesTemplate Template:Neuroscience-stub.
- Horsley–Clarke_apparatus wikiPageUsesTemplate Template:Unreferenced.
- Horsley–Clarke_apparatus subject Category:History_of_neuroscience.
- Horsley–Clarke_apparatus subject Category:Medical_equipment.
- Horsley–Clarke_apparatus comment "The Horsley–Clarke apparatus is a device invented in 1908 by British neurosurgeon and scientist Sir Victor A.H. Horsley and his colleague Robert H. Clarke at University College London to allow experimental and surgical intervention in deep-seated structures of the brain in vertebrates.Also called a stereotactic device, the system uses a set of three coordinates (x, y, and z) in an orthogonal frame of reference (cartesian coordinates).".
- Horsley–Clarke_apparatus label "Horsley–Clarke apparatus".
- Horsley–Clarke_apparatus sameAs m.04b0d9.
- Horsley–Clarke_apparatus sameAs Q5906392.
- Horsley–Clarke_apparatus sameAs Q5906392.
- Horsley–Clarke_apparatus wasDerivedFrom Horsley–Clarke_apparatus?oldid=551255485.
- Horsley–Clarke_apparatus isPrimaryTopicOf Horsley–Clarke_apparatus.