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- Holocarboxylase_synthetase abstract "HLCS (holocarboxylase synthetase (biotin-(propionyl-Coenzyme A-carboxylase (ATP-hydrolysing)) ligase)) is a human gene that provides instructions for making an enzyme called holocarboxylase synthetase (EC 6.3.4.10). This enzyme is important for the effective use of biotin, a B vitamin found in foods such as liver, egg yolks, and milk. In many of the body's tissues, holocarboxylase synthetase activates other specific enzymes (called biotin-dependent carboxylases) by attaching biotin to them. These carboxylases are involved in many critical cellular functions, including the production and breakdown of proteins, fats, and carbohydrates.Holocarboxylase synthetase may also play a role in regulating the activity of genes. In the nucleus, the enzyme likely attaches biotin molecules to histones, which are structural proteins that bind to DNA and give chromosomes their shape. Changing the shape of histones may help determine whether certain genes are turned on or off; however, it is not known how adding biotin affects gene regulation.The HLCS gene is located on the long (q) arm of chromosome 21 at position 22.1, from base pair 37,045,059 to base pair 37,284,372.".
- Holocarboxylase_synthetase arm "q".
- Holocarboxylase_synthetase band "22.1".
- Holocarboxylase_synthetase chromosome "21".
- Holocarboxylase_synthetase ecNumber "6.3.4.10".
- Holocarboxylase_synthetase entrezgene "3141".
- Holocarboxylase_synthetase hgncid "4976".
- Holocarboxylase_synthetase omim "609018".
- Holocarboxylase_synthetase refseq "NM_000411".
- Holocarboxylase_synthetase symbol "HLCS".
- Holocarboxylase_synthetase uniprot "P50747".
- Holocarboxylase_synthetase wikiPageID "3573437".
- Holocarboxylase_synthetase wikiPageLength "2702".
- Holocarboxylase_synthetase wikiPageOutDegree "18".
- Holocarboxylase_synthetase wikiPageRevisionID "622848866".
- Holocarboxylase_synthetase wikiPageWikiLink Amino_acid.
- Holocarboxylase_synthetase wikiPageWikiLink Base_pair.
- Holocarboxylase_synthetase wikiPageWikiLink Biotin.
- Holocarboxylase_synthetase wikiPageWikiLink Biotinylation.
- Holocarboxylase_synthetase wikiPageWikiLink Carbohydrate.
- Holocarboxylase_synthetase wikiPageWikiLink Carboxylase.
- Holocarboxylase_synthetase wikiPageWikiLink Carboxylation.
- Holocarboxylase_synthetase wikiPageWikiLink Category:Human_genes.
- Holocarboxylase_synthetase wikiPageWikiLink Chromosome_21_(human).
- Holocarboxylase_synthetase wikiPageWikiLink Egg_yolk.
- Holocarboxylase_synthetase wikiPageWikiLink Fat.
- Holocarboxylase_synthetase wikiPageWikiLink Gene.
- Holocarboxylase_synthetase wikiPageWikiLink Histone.
- Holocarboxylase_synthetase wikiPageWikiLink Holocarboxylase_synthetase_deficiency.
- Holocarboxylase_synthetase wikiPageWikiLink Human.
- Holocarboxylase_synthetase wikiPageWikiLink Liver.
- Holocarboxylase_synthetase wikiPageWikiLink Milk.
- Holocarboxylase_synthetase wikiPageWikiLink Mutation.
- Holocarboxylase_synthetase wikiPageWikiLink Protein.
- Holocarboxylase_synthetase wikiPageWikiLink Yolk.
- Holocarboxylase_synthetase wikiPageWikiLinkText "Holocarboxylase synthetase".
- Holocarboxylase_synthetase wikiPageWikiLinkText "holocarboxylase synthetase".
- Holocarboxylase_synthetase arm "q".
- Holocarboxylase_synthetase band "22.1".
- Holocarboxylase_synthetase chromosome "21".
- Holocarboxylase_synthetase ecnumber "6.3".
- Holocarboxylase_synthetase entrezgene "3141".
- Holocarboxylase_synthetase hasPhotoCollection Holocarboxylase_synthetase.
- Holocarboxylase_synthetase hgncid "4976".
- Holocarboxylase_synthetase name "holocarboxylase synthetase".
- Holocarboxylase_synthetase omim "609018".
- Holocarboxylase_synthetase refseq "NM_000411".
- Holocarboxylase_synthetase symbol "HLCS".
- Holocarboxylase_synthetase uniprot "P50747".
- Holocarboxylase_synthetase wikiPageUsesTemplate Template:EC_number.
- Holocarboxylase_synthetase wikiPageUsesTemplate Template:Infobox_protein.
- Holocarboxylase_synthetase wikiPageUsesTemplate Template:Ligases.
- Holocarboxylase_synthetase wikiPageUsesTemplate Template:MeshName.
- Holocarboxylase_synthetase subject Category:Human_genes.
- Holocarboxylase_synthetase hypernym Gene.
- Holocarboxylase_synthetase type Biomolecule.
- Holocarboxylase_synthetase type Protein.
- Holocarboxylase_synthetase type Thing.
- Holocarboxylase_synthetase type Q206229.
- Holocarboxylase_synthetase type Q8054.
- Holocarboxylase_synthetase comment "HLCS (holocarboxylase synthetase (biotin-(propionyl-Coenzyme A-carboxylase (ATP-hydrolysing)) ligase)) is a human gene that provides instructions for making an enzyme called holocarboxylase synthetase (EC 6.3.4.10). This enzyme is important for the effective use of biotin, a B vitamin found in foods such as liver, egg yolks, and milk. In many of the body's tissues, holocarboxylase synthetase activates other specific enzymes (called biotin-dependent carboxylases) by attaching biotin to them.".
- Holocarboxylase_synthetase label "Holocarboxylase synthetase".
- Holocarboxylase_synthetase sameAs Holocarboxilasa_sintetasa.
- Holocarboxylase_synthetase sameAs m.09mg1y.
- Holocarboxylase_synthetase sameAs Q9004493.
- Holocarboxylase_synthetase sameAs Q9004493.
- Holocarboxylase_synthetase wasDerivedFrom Holocarboxylase_synthetase?oldid=622848866.
- Holocarboxylase_synthetase isPrimaryTopicOf Holocarboxylase_synthetase.
- Holocarboxylase_synthetase name "holocarboxylase synthetase (biotin-(propionyl-Coenzyme A-carboxylase (ATP-hydrolysing)) ligase)".