Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Hin_recombinase> ?p ?o }
Showing triples 1 to 53 of
53
with 100 triples per page.
- Hin_recombinase abstract "Hin recombinase is a 21kD protein composed of 198 amino acids that is found in the bacteria Salmonella. Hin belongs to the serine recombinase family of DNA invertases in which it relies on the active site serine to initiate DNA cleavage and recombination. The related protein, gamma-delta resolvase shares high similarity to Hin, of which much structural work has been done, including structures bound to DNA and reaction intermediates. Hin functions to invert a 900 base pair (bp) DNA segment within the salmonella genome that contains a promoter for downstream flagellar genes, fljA and fljB. Inversion of the intervening DNA alternates the direction of the promoter and thereby alternates expression of the flagellar genes. This is advantageous to the bacterium as a means of escape from the host immune response. Hin functions by binding to two 26bp imperfect inverted repeat sequences as a homodimer. These hin binding sites flank the invertible segment which not only encodes the Hin gene itself, but also contains an enhancer element to which the bacterial Fis proteins binds with nanomolar affinity. Four molecules of Fis bind to this site as a homodimers and are required for the recombination reaction to proceeded. The initial reaction requires binding of Hin and Fis to their respective DNA sequences and assemble into a higher-order nucleoprotein complex with branched plectonemic supercoils with the aid of the DNA bending protein HU. At this point, it is believed that the Fis protein modulates subtle contacts to activate the reaction, possibly through direct interactions with the Hin protein. Activation of the 4 catalytic serine residues within the Hin tetramer make a 2-bp double stranded DNA break and forms a covalent reaction intermediate. The DNA cleavage event also requires the divalent metal cation magnesium. A large conformational change reveals a large hydrophobic interface that allows for subunit rotation which may be driven by superhelical torsion within the protein-DNA complex. After this 180° rotation, Hin returns to its native conformation and re-ligates the cleaved DNA, without the aid of high energy cofactors and without the loss of any DNA.".
- Hin_recombinase wikiPageID "8559750".
- Hin_recombinase wikiPageLength "3674".
- Hin_recombinase wikiPageOutDegree "27".
- Hin_recombinase wikiPageRevisionID "653167932".
- Hin_recombinase wikiPageWikiLink Active_site.
- Hin_recombinase wikiPageWikiLink Amino_acid.
- Hin_recombinase wikiPageWikiLink Base_pair.
- Hin_recombinase wikiPageWikiLink Category:Molecular_biology.
- Hin_recombinase wikiPageWikiLink Cation.
- Hin_recombinase wikiPageWikiLink Conformational_change.
- Hin_recombinase wikiPageWikiLink DNA_invertase.
- Hin_recombinase wikiPageWikiLink DNA_supercoil.
- Hin_recombinase wikiPageWikiLink FIS_(protein).
- Hin_recombinase wikiPageWikiLink Flagella.
- Hin_recombinase wikiPageWikiLink Flagellum.
- Hin_recombinase wikiPageWikiLink Gamma-delta_resolvase.
- Hin_recombinase wikiPageWikiLink Gene_expression.
- Hin_recombinase wikiPageWikiLink Genome.
- Hin_recombinase wikiPageWikiLink Homodimer.
- Hin_recombinase wikiPageWikiLink Host_(biology).
- Hin_recombinase wikiPageWikiLink Hydrophobe.
- Hin_recombinase wikiPageWikiLink Hydrophobic.
- Hin_recombinase wikiPageWikiLink Immune_response.
- Hin_recombinase wikiPageWikiLink Immune_system.
- Hin_recombinase wikiPageWikiLink Ion.
- Hin_recombinase wikiPageWikiLink Magnesium.
- Hin_recombinase wikiPageWikiLink Nucleoprotein.
- Hin_recombinase wikiPageWikiLink Promoter_(biology).
- Hin_recombinase wikiPageWikiLink Promoter_(genetics).
- Hin_recombinase wikiPageWikiLink Protein.
- Hin_recombinase wikiPageWikiLink Protein_dimer.
- Hin_recombinase wikiPageWikiLink Reaction_intermediate.
- Hin_recombinase wikiPageWikiLink Salmonella.
- Hin_recombinase wikiPageWikiLink Serine.
- Hin_recombinase wikiPageWikiLink Serine_recombinase.
- Hin_recombinase wikiPageWikiLink Supercoil.
- Hin_recombinase wikiPageWikiLink Tetrameric_protein.
- Hin_recombinase wikiPageWikiLink Upstream_and_downstream_(DNA).
- Hin_recombinase wikiPageWikiLinkText "Hin recombinase".
- Hin_recombinase wikiPageWikiLinkText "hin".
- Hin_recombinase hasPhotoCollection Hin_recombinase.
- Hin_recombinase wikiPageUsesTemplate Template:Cite_journal.
- Hin_recombinase subject Category:Molecular_biology.
- Hin_recombinase hypernym Protein.
- Hin_recombinase type Protein.
- Hin_recombinase comment "Hin recombinase is a 21kD protein composed of 198 amino acids that is found in the bacteria Salmonella. Hin belongs to the serine recombinase family of DNA invertases in which it relies on the active site serine to initiate DNA cleavage and recombination. The related protein, gamma-delta resolvase shares high similarity to Hin, of which much structural work has been done, including structures bound to DNA and reaction intermediates.".
- Hin_recombinase label "Hin recombinase".
- Hin_recombinase sameAs m.0277ww3.
- Hin_recombinase sameAs Q17143041.
- Hin_recombinase sameAs Q17143041.
- Hin_recombinase wasDerivedFrom Hin_recombinase?oldid=653167932.
- Hin_recombinase isPrimaryTopicOf Hin_recombinase.