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- High_endothelial_venules abstract "High endothelial venules (HEV) are specialized post-capillary venous swellings characterized by plump endothelial cells as opposed to the usual thinner endothelial cells found in regular venules. HEVs enable lymphocytes circulating in the blood to directly enter a lymph node (by crossing through the HEV).In humans, HEVs are found in all secondary lymphoid organs (with the exception of spleen, where blood exits through open arterioles and enters the red pulp), including hundreds of lymph nodes dispersed in the body, tonsils and adenoids in the pharynx, Peyer's patches (PIs) in the small intestine, appendix, and small aggregates of lymphoid tissue in the stomach and large intestine. In contrast to the endothelial cells from other vessels, the high endothelial cells of HEVs have a distinctive appearance, consisting of a cuboidal morphology and with various receptors to interact with leukocytes (express specialized ligands for lymphocytes and are able to support high levels of lymphocyte extravasation). HEVs enable naïve lymphocytes to move in and out of the lymph nodes from the circulatory system. HEV cells express addressins, which are specific adhesion molecules that attach to the L-selectins on lymphocytes and anchor them to the HEV wall in preparation for crossing the endothelium.The endothelial cells of HEVs have a 'plump' appearance different from the flat morphology of endothelial cells that line other vessels, and are therefore called high endothelial cells by reference to their thickness. Another characteristic of HEVs, revealed by light-microscopic examination, is the presence of a large number of lymphocytes within their walls. This illustrates the function of HEVs in lymphocyte recruitment, and explains why these vessels were implicated in lymphocyte traffic from the time of their initial description.".
- High_endothelial_venules wikiPageID "7026804".
- High_endothelial_venules wikiPageLength "9558".
- High_endothelial_venules wikiPageOutDegree "31".
- High_endothelial_venules wikiPageRevisionID "670161762".
- High_endothelial_venules wikiPageWikiLink Adaptive_immune_response.
- High_endothelial_venules wikiPageWikiLink Adaptive_immune_system.
- High_endothelial_venules wikiPageWikiLink Addressin.
- High_endothelial_venules wikiPageWikiLink Adenoid.
- High_endothelial_venules wikiPageWikiLink Antigen-presenting_cell.
- High_endothelial_venules wikiPageWikiLink Blood.
- High_endothelial_venules wikiPageWikiLink CCL21.
- High_endothelial_venules wikiPageWikiLink CC_chemokine_receptors.
- High_endothelial_venules wikiPageWikiLink CD11c.
- High_endothelial_venules wikiPageWikiLink CD34.
- High_endothelial_venules wikiPageWikiLink Capillary.
- High_endothelial_venules wikiPageWikiLink Category:Angiology.
- High_endothelial_venules wikiPageWikiLink Category:Tissues_(biology).
- High_endothelial_venules wikiPageWikiLink Chemokine.
- High_endothelial_venules wikiPageWikiLink Dendritic_cell.
- High_endothelial_venules wikiPageWikiLink Dendritic_cells.
- High_endothelial_venules wikiPageWikiLink Endothelial_cell.
- High_endothelial_venules wikiPageWikiLink Endothelium.
- High_endothelial_venules wikiPageWikiLink Extravasation.
- High_endothelial_venules wikiPageWikiLink Gut-associated_lymphoid_tissue.
- High_endothelial_venules wikiPageWikiLink ICAM-1.
- High_endothelial_venules wikiPageWikiLink L-selectin.
- High_endothelial_venules wikiPageWikiLink Leukocyte.
- High_endothelial_venules wikiPageWikiLink Lymph_node.
- High_endothelial_venules wikiPageWikiLink Lymphatic_system.
- High_endothelial_venules wikiPageWikiLink Lymphocyte.
- High_endothelial_venules wikiPageWikiLink Lymphocytes.
- High_endothelial_venules wikiPageWikiLink Lymphotoxin.
- High_endothelial_venules wikiPageWikiLink Peyers_patch.
- High_endothelial_venules wikiPageWikiLink Peyers_patches.
- High_endothelial_venules wikiPageWikiLink Red_pulp.
- High_endothelial_venules wikiPageWikiLink Secondary_lymphoid_organs.
- High_endothelial_venules wikiPageWikiLink Spleen.
- High_endothelial_venules wikiPageWikiLink T_cell.
- High_endothelial_venules wikiPageWikiLink Tonsil.
- High_endothelial_venules wikiPageWikiLink Venule.
- High_endothelial_venules wikiPageWikiLink Venules.
- High_endothelial_venules wikiPageWikiLink White_blood_cell.
- High_endothelial_venules wikiPageWikiLinkText "High endothelial venules".
- High_endothelial_venules wikiPageWikiLinkText "high endothelial cells".
- High_endothelial_venules wikiPageWikiLinkText "high endothelial venules".
- High_endothelial_venules hasPhotoCollection High_endothelial_venules.
- High_endothelial_venules wikiPageUsesTemplate Template:Lymphatic_system.
- High_endothelial_venules subject Category:Angiology.
- High_endothelial_venules subject Category:Tissues_(biology).
- High_endothelial_venules type Specialty.
- High_endothelial_venules type Tissue.
- High_endothelial_venules comment "High endothelial venules (HEV) are specialized post-capillary venous swellings characterized by plump endothelial cells as opposed to the usual thinner endothelial cells found in regular venules.".
- High_endothelial_venules label "High endothelial venules".
- High_endothelial_venules sameAs Hochendotheliale_Venole.
- High_endothelial_venules sameAs سیاهرگچه_لایه_درون_رگی.
- High_endothelial_venules sameAs Veinule_à_endothélium_épais.
- High_endothelial_venules sameAs Venule_ad_endotelio_alto.
- High_endothelial_venules sameAs m.0h0z6g.
- High_endothelial_venules sameAs HEV.
- High_endothelial_venules sameAs Q637997.
- High_endothelial_venules sameAs Q637997.
- High_endothelial_venules wasDerivedFrom High_endothelial_venules?oldid=670161762.
- High_endothelial_venules isPrimaryTopicOf High_endothelial_venules.