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- Hfq_protein abstract "The Hfq protein (also known as HF-I protein) encoded by the hfq gene was discovered in 1968 as an Escherichia coli host factor that was essential for replication of the bacteriophage Qβ. It is now clear that Hfq is an abundant bacterial RNA binding protein which has many important physiological roles that are usually mediated by interacting with Hfq binding sRNA.In E. coli, Hfq mutants show multiple stress response related phenotypes. The Hfq protein is now known to regulate the translation of two major stress transcription factors ( σS (RpoS) and σE (RpoE) ) in Enterobacteria. It also regulates sRNA in Vibrio cholerae, a specific example being MicX sRNA.In Salmonella typhimurium Hfq has been shown to be an essential virulence factor as its deletion attenuates the ability of S.typhimurium to invade epithelial cells, secrete virulence factors or survive in cultured macrophages. In Salmonella Hfq deletion mutants are also non motile and exhibit chronic activation of the sigma mediated envelope stress response.Hfq mediates its pleiotropic effects through several mechanisms. It interacts with regulatory sRNA and facilitates their antisense interaction with their targets. It also acts independently to modulate mRNA decay (directing mRNA transcripts for degradation) and also acts as a repressor of mRNA translation. Genomic SELEX has been used to show that Hfq binding RNAs are enriched in the sequence motif 5'-AAYAAYAA-3'.Electron microscopy imaging reveals that, in addition to the expected localization of this protein in cytoplasmic regions and in the nucleoid, an important fraction of Hfq is located in close proximity to the membrane.".
- Hfq_protein thumbnail LSm_1I5L_1.JPG?width=300.
- Hfq_protein wikiPageID "11882145".
- Hfq_protein wikiPageLength "6770".
- Hfq_protein wikiPageOutDegree "23".
- Hfq_protein wikiPageRevisionID "678913075".
- Hfq_protein wikiPageWikiLink Antisense.
- Hfq_protein wikiPageWikiLink Bacteriophage_Qβ.
- Hfq_protein wikiPageWikiLink Category:Bacterial_proteins.
- Hfq_protein wikiPageWikiLink Category:Molecular_biology.
- Hfq_protein wikiPageWikiLink Category:Proteins.
- Hfq_protein wikiPageWikiLink E._coli.
- Hfq_protein wikiPageWikiLink Enteric_bacteria.
- Hfq_protein wikiPageWikiLink Epithelial_cells.
- Hfq_protein wikiPageWikiLink Epithelium.
- Hfq_protein wikiPageWikiLink Escherichia_coli.
- Hfq_protein wikiPageWikiLink Gut_flora.
- Hfq_protein wikiPageWikiLink Hfq_binding_sRNA.
- Hfq_protein wikiPageWikiLink M._jannaschii.
- Hfq_protein wikiPageWikiLink Macrophage.
- Hfq_protein wikiPageWikiLink Macrophages.
- Hfq_protein wikiPageWikiLink MicX_sRNA.
- Hfq_protein wikiPageWikiLink P._aeruginosa.
- Hfq_protein wikiPageWikiLink Pseudomonas_aeruginosa.
- Hfq_protein wikiPageWikiLink Salmonella_enterica_subsp._enterica.
- Hfq_protein wikiPageWikiLink Salmonella_typhimurium.
- Hfq_protein wikiPageWikiLink Sense_(molecular_biology).
- Hfq_protein wikiPageWikiLink Sequence_motif.
- Hfq_protein wikiPageWikiLink Staphylococcus_aureus.
- Hfq_protein wikiPageWikiLink Transcription_(genetics).
- Hfq_protein wikiPageWikiLink Translation_(biology).
- Hfq_protein wikiPageWikiLink Vibrio_cholerae.
- Hfq_protein wikiPageWikiLink Virulence_factor.
- Hfq_protein wikiPageWikiLink Virulence_factors.
- Hfq_protein wikiPageWikiLink File:LSm_1I5L_1.JPG.
- Hfq_protein wikiPageWikiLinkText "Hfq protein".
- Hfq_protein wikiPageWikiLinkText "Hfq".
- Hfq_protein wikiPageWikiLinkText "Hfq_protein".
- Hfq_protein wikiPageWikiLinkText "RNA chaperone Hfq".
- Hfq_protein hasPhotoCollection Hfq_protein.
- Hfq_protein wikiPageUsesTemplate Template:MeshName.
- Hfq_protein wikiPageUsesTemplate Template:Molecular-cell-biology-stub.
- Hfq_protein wikiPageUsesTemplate Template:PDB.
- Hfq_protein wikiPageUsesTemplate Template:PDB2.
- Hfq_protein wikiPageUsesTemplate Template:RNA-binding_proteins.
- Hfq_protein wikiPageUsesTemplate Template:Reflist.
- Hfq_protein subject Category:Bacterial_proteins.
- Hfq_protein subject Category:Molecular_biology.
- Hfq_protein subject Category:Proteins.
- Hfq_protein type Biomolecule.
- Hfq_protein type Biomolecule.
- Hfq_protein type Nutrient.
- Hfq_protein comment "The Hfq protein (also known as HF-I protein) encoded by the hfq gene was discovered in 1968 as an Escherichia coli host factor that was essential for replication of the bacteriophage Qβ. It is now clear that Hfq is an abundant bacterial RNA binding protein which has many important physiological roles that are usually mediated by interacting with Hfq binding sRNA.In E. coli, Hfq mutants show multiple stress response related phenotypes.".
- Hfq_protein label "Hfq protein".
- Hfq_protein sameAs m.02rwnfk.
- Hfq_protein sameAs Q17148058.
- Hfq_protein sameAs Q17148058.
- Hfq_protein wasDerivedFrom Hfq_protein?oldid=678913075.
- Hfq_protein depiction LSm_1I5L_1.JPG.
- Hfq_protein isPrimaryTopicOf Hfq_protein.