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- Heparan_sulfate_analogue abstract "Heparan sulfate analogues are polymers engineered to mimic several properties of heparan sulfates. They can be constituted with a backbone of polysaccharides, such as poly glucose or glucuronates or a polyester such as co polymers of lactic or malic acid to which sulfates, sulfonate or carboxylgroups are added in controlled amounts and location. They have a molecular weight that can range from a few thousands to several hundred thousand Dalton.Heparan sulfates can sequester growth factors (GFs) and cytokines in the extracellular matrix (ECM) thereby protecting them from degradation. This ensures local presence of these signaling proteins to fulfill their function in the ECM which contributes to the preservation of anatomical form and function. Heparan sulfates bind to matrix proteins on specific sites called "heparan sulfate binding sites" on ECM macromolecules like collagen, fibronectin and laminin, to form a scaffold surrounding the cells and to protect ECM proteins and growth factors from proteolytic degradation by steric hindrance. However, at any site of inflammation, so also in wound areas, heparan sulfates are degraded, mainly by heparanases giving free access to protease to degrade the ECM and a subsequent loss of GFs and cytokines that disrupts the normal tissue homeostasis. Heparan sulfate analogues obtain many of the characteristics of heparan sulfates including the ability to sequester GFs and bind and protect matrix proteins. However, heparan sulfate analogues are resistant to enzymatic degradation. This way they strengthen the healing potential of the wound bed by repositioning GFs and cytokines back into the ECM.".
- Heparan_sulfate_analogue thumbnail Heparan_sulfate_analogue.png?width=300.
- Heparan_sulfate_analogue wikiPageID "33472095".
- Heparan_sulfate_analogue wikiPageLength "10695".
- Heparan_sulfate_analogue wikiPageOutDegree "30".
- Heparan_sulfate_analogue wikiPageRevisionID "682749105".
- Heparan_sulfate_analogue wikiPageWikiLink Atomic_mass_unit.
- Heparan_sulfate_analogue wikiPageWikiLink Category:Glycosaminoglycans.
- Heparan_sulfate_analogue wikiPageWikiLink Cell_growth.
- Heparan_sulfate_analogue wikiPageWikiLink Cell_proliferation.
- Heparan_sulfate_analogue wikiPageWikiLink Cellular_differentiation.
- Heparan_sulfate_analogue wikiPageWikiLink Cytokine.
- Heparan_sulfate_analogue wikiPageWikiLink Cytokines.
- Heparan_sulfate_analogue wikiPageWikiLink Dalton_(unit).
- Heparan_sulfate_analogue wikiPageWikiLink Diabetes_Mellitus.
- Heparan_sulfate_analogue wikiPageWikiLink Diabetes_mellitus.
- Heparan_sulfate_analogue wikiPageWikiLink Enzyme.
- Heparan_sulfate_analogue wikiPageWikiLink Extracellular_matrix.
- Heparan_sulfate_analogue wikiPageWikiLink Glucuronates.
- Heparan_sulfate_analogue wikiPageWikiLink Glucuronic_acid.
- Heparan_sulfate_analogue wikiPageWikiLink Growth_factor.
- Heparan_sulfate_analogue wikiPageWikiLink Hemostasis.
- Heparan_sulfate_analogue wikiPageWikiLink Heparan_sulfate.
- Heparan_sulfate_analogue wikiPageWikiLink Heparanase.
- Heparan_sulfate_analogue wikiPageWikiLink Infection.
- Heparan_sulfate_analogue wikiPageWikiLink Inflammation.
- Heparan_sulfate_analogue wikiPageWikiLink Ischemia.
- Heparan_sulfate_analogue wikiPageWikiLink Macrophage.
- Heparan_sulfate_analogue wikiPageWikiLink Macrophages.
- Heparan_sulfate_analogue wikiPageWikiLink Malic_acid.
- Heparan_sulfate_analogue wikiPageWikiLink Metalloproteinase.
- Heparan_sulfate_analogue wikiPageWikiLink Polysaccharide.
- Heparan_sulfate_analogue wikiPageWikiLink Polysaccharides.
- Heparan_sulfate_analogue wikiPageWikiLink Randomized_controlled_trial.
- Heparan_sulfate_analogue wikiPageWikiLink Regenerative_medicine.
- Heparan_sulfate_analogue wikiPageWikiLink Wound.
- Heparan_sulfate_analogue wikiPageWikiLink Wound_healing.
- Heparan_sulfate_analogue wikiPageWikiLink Wound_repair.
- Heparan_sulfate_analogue wikiPageWikiLink File:Clinical_case_heparan_sulfate_analogues.jpg.
- Heparan_sulfate_analogue wikiPageWikiLink File:Heparan_sulfate_analogue.png.
- Heparan_sulfate_analogue wikiPageWikiLinkText "Heparan sulfate analogue".
- Heparan_sulfate_analogue hasPhotoCollection Heparan_sulfate_analogue.
- Heparan_sulfate_analogue wikiPageUsesTemplate Template:Reflist.
- Heparan_sulfate_analogue subject Category:Glycosaminoglycans.
- Heparan_sulfate_analogue hypernym Polymers.
- Heparan_sulfate_analogue type ChemicalCompound.
- Heparan_sulfate_analogue type Polysaccharide.
- Heparan_sulfate_analogue type Polymer.
- Heparan_sulfate_analogue type Polysaccharide.
- Heparan_sulfate_analogue comment "Heparan sulfate analogues are polymers engineered to mimic several properties of heparan sulfates. They can be constituted with a backbone of polysaccharides, such as poly glucose or glucuronates or a polyester such as co polymers of lactic or malic acid to which sulfates, sulfonate or carboxylgroups are added in controlled amounts and location.".
- Heparan_sulfate_analogue label "Heparan sulfate analogue".
- Heparan_sulfate_analogue sameAs m.0hgmsmn.
- Heparan_sulfate_analogue sameAs Q5731642.
- Heparan_sulfate_analogue sameAs Q5731642.
- Heparan_sulfate_analogue wasDerivedFrom Heparan_sulfate_analogue?oldid=682749105.
- Heparan_sulfate_analogue depiction Heparan_sulfate_analogue.png.
- Heparan_sulfate_analogue isPrimaryTopicOf Heparan_sulfate_analogue.