Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/HMR_1883> ?p ?o }
Showing triples 1 to 34 of
34
with 100 triples per page.
- HMR_1883 abstract "HMR 1883 (1-[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenyl]sulfonyl-3 methylthiourea) and its sodium salt HMR 1098, are experimental anti-arrhythmic drugs classified as sulfonylthiourea compounds. Their main purpose is to treat ventricular fibrillation caused by myocardial ischemia. They were synthesized via structural modifications to glibenclamide, an antidiabetic drug. Both HMR 1883 and glibenclamide act by inactivating the ATP-sensitive potassium channels (KATP) responsible for potassium efflux. Unlike glibenclamide, HMR 1883 has been suggested to target selectively the Kir6.2/SUR2A KATP subtype, found mostly in the membranes of cardiac cells. However, data showing that HMR 1098 inhibits the Kir6.2/SUR1 KATP subtype found in insulin-secreting pancreatic beta cells challenges this view.".
- HMR_1883 wikiPageID "31280214".
- HMR_1883 wikiPageLength "6743".
- HMR_1883 wikiPageOutDegree "11".
- HMR_1883 wikiPageRevisionID "640341428".
- HMR_1883 wikiPageWikiLink Adenosine_triphosphate.
- HMR_1883 wikiPageWikiLink Anti-diabetic_medication.
- HMR_1883 wikiPageWikiLink Antiarrhythmic_agent.
- HMR_1883 wikiPageWikiLink Category:Potassium_channel_blockers.
- HMR_1883 wikiPageWikiLink Cell_membrane.
- HMR_1883 wikiPageWikiLink Coronary_artery_disease.
- HMR_1883 wikiPageWikiLink Efflux_(microbiology).
- HMR_1883 wikiPageWikiLink Glibenclamide.
- HMR_1883 wikiPageWikiLink Myocardial_ischemia.
- HMR_1883 wikiPageWikiLink Salt_(chemistry).
- HMR_1883 wikiPageWikiLink Sulfonylthiourea.
- HMR_1883 wikiPageWikiLink Ventricular_fibrillation.
- HMR_1883 hasPhotoCollection HMR_1883.
- HMR_1883 wikiPageUsesTemplate Template:Multiple_issues.
- HMR_1883 wikiPageUsesTemplate Template:Reflist.
- HMR_1883 subject Category:Potassium_channel_blockers.
- HMR_1883 hypernym Drugs.
- HMR_1883 type Agent.
- HMR_1883 type Article.
- HMR_1883 type Drug.
- HMR_1883 type Agent.
- HMR_1883 type Article.
- HMR_1883 comment "HMR 1883 (1-[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenyl]sulfonyl-3 methylthiourea) and its sodium salt HMR 1098, are experimental anti-arrhythmic drugs classified as sulfonylthiourea compounds. Their main purpose is to treat ventricular fibrillation caused by myocardial ischemia. They were synthesized via structural modifications to glibenclamide, an antidiabetic drug.".
- HMR_1883 label "HMR 1883".
- HMR_1883 sameAs m.0gjbpzw.
- HMR_1883 sameAs Q5631166.
- HMR_1883 sameAs Q5631166.
- HMR_1883 wasDerivedFrom HMR_1883?oldid=640341428.
- HMR_1883 isPrimaryTopicOf HMR_1883.