Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/HMG-CoA_reductase> ?p ?o }
- HMG-CoA_reductase abstract "HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase, officially abbreviated HMGCR) is the rate-controlling enzyme (NADH-dependent, EC 1.1.1.88; NADPH-dependent, EC 1.1.1.34) of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor as well as oxidized species of cholesterol. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. This enzyme is thus the target of the widely available cholesterol-lowering drugs known collectively as the statins. HMG-CoA reductase is anchored in the membrane of the endoplasmic reticulum, and was long regarded as having seven transmembrane domains, with the active site located in a long carboxyl terminal domain in the cytosol. More recent evidence shows it to contain eight transmembrane domains.In humans, the gene for HMG-CoA reductase is located on the long arm of the fifth chromosome (5q13.3-14). Related enzymes having the same function are also present in other animals, plants and bacteria.".
- HMG-CoA_reductase entrezgene "3156".
- HMG-CoA_reductase thumbnail Mevalonate_pathway.svg?width=300.
- HMG-CoA_reductase wikiPageExternalLink cholesterol.htm.
- HMG-CoA_reductase wikiPageID "864596".
- HMG-CoA_reductase wikiPageLength "23391".
- HMG-CoA_reductase wikiPageOutDegree "65".
- HMG-CoA_reductase wikiPageRevisionID "674193835".
- HMG-CoA_reductase wikiPageWikiLink AMFR.
- HMG-CoA_reductase wikiPageWikiLink AMP-activated_protein_kinase.
- HMG-CoA_reductase wikiPageWikiLink Acetyl-CoA_carboxylase.
- HMG-CoA_reductase wikiPageWikiLink Adenosine_monophosphate.
- HMG-CoA_reductase wikiPageWikiLink Adiponectin.
- HMG-CoA_reductase wikiPageWikiLink Alpha_helix.
- HMG-CoA_reductase wikiPageWikiLink Atorvastatin.
- HMG-CoA_reductase wikiPageWikiLink Cardiovascular_disease.
- HMG-CoA_reductase wikiPageWikiLink Category:EC_1.1.1.
- HMG-CoA_reductase wikiPageWikiLink Cell_nucleus.
- HMG-CoA_reductase wikiPageWikiLink Cholesterol.
- HMG-CoA_reductase wikiPageWikiLink Chromosome.
- HMG-CoA_reductase wikiPageWikiLink ERAD.
- HMG-CoA_reductase wikiPageWikiLink Endoplasmic-reticulum-associated_protein_degradation.
- HMG-CoA_reductase wikiPageWikiLink Endoplasmic_reticulum.
- HMG-CoA_reductase wikiPageWikiLink Enzyme.
- HMG-CoA_reductase wikiPageWikiLink Ezetimibe.
- HMG-CoA_reductase wikiPageWikiLink simvastatin.
- HMG-CoA_reductase wikiPageWikiLink Farnesol.
- HMG-CoA_reductase wikiPageWikiLink Fluvastatin.
- HMG-CoA_reductase wikiPageWikiLink Gene.
- HMG-CoA_reductase wikiPageWikiLink Glucagon.
- HMG-CoA_reductase wikiPageWikiLink HMG-CoA.
- HMG-CoA_reductase wikiPageWikiLink HMG-CoA_reductase_inhibitor.
- HMG-CoA_reductase wikiPageWikiLink Heart_disease.
- HMG-CoA_reductase wikiPageWikiLink Insulin.
- HMG-CoA_reductase wikiPageWikiLink Isoprenoids.
- HMG-CoA_reductase wikiPageWikiLink Leptin.
- HMG-CoA_reductase wikiPageWikiLink Lovastatin.
- HMG-CoA_reductase wikiPageWikiLink MRNA.
- HMG-CoA_reductase wikiPageWikiLink Messenger_RNA.
- HMG-CoA_reductase wikiPageWikiLink Metabolic_pathway.
- HMG-CoA_reductase wikiPageWikiLink Mevalonate.
- HMG-CoA_reductase wikiPageWikiLink Mevalonic_acid.
- HMG-CoA_reductase wikiPageWikiLink Multiple_sclerosis.
- HMG-CoA_reductase wikiPageWikiLink Nuclear_membrane.
- HMG-CoA_reductase wikiPageWikiLink Oxidoreductase.
- HMG-CoA_reductase wikiPageWikiLink Phosphorylation.
- HMG-CoA_reductase wikiPageWikiLink Pitavastatin.
- HMG-CoA_reductase wikiPageWikiLink Pravastatin.
- HMG-CoA_reductase wikiPageWikiLink Proteolysis.
- HMG-CoA_reductase wikiPageWikiLink Red_yeast_rice.
- HMG-CoA_reductase wikiPageWikiLink Rosuvastatin.
- HMG-CoA_reductase wikiPageWikiLink Simvastatin.
- HMG-CoA_reductase wikiPageWikiLink Statin.
- HMG-CoA_reductase wikiPageWikiLink Statins.
- HMG-CoA_reductase wikiPageWikiLink Sterol.
- HMG-CoA_reductase wikiPageWikiLink Sterol-sensing_domain.
- HMG-CoA_reductase wikiPageWikiLink Sterol_regulatory_element.
- HMG-CoA_reductase wikiPageWikiLink Sterol_regulatory_element-binding_protein.
- HMG-CoA_reductase wikiPageWikiLink Sterol_regulatory_element_binding_protein.
- HMG-CoA_reductase wikiPageWikiLink Terpenoid.
- HMG-CoA_reductase wikiPageWikiLink Transcription_(genetics).
- HMG-CoA_reductase wikiPageWikiLink Translation_(biology).
- HMG-CoA_reductase wikiPageWikiLink Translation_(genetics).
- HMG-CoA_reductase wikiPageWikiLink Transmembrane_protein.
- HMG-CoA_reductase wikiPageWikiLink Vytorin.
- HMG-CoA_reductase wikiPageWikiLink File:HMGCOA-1DQA.png.
- HMG-CoA_reductase wikiPageWikiLink File:Mevalonate_pathway.svg.
- HMG-CoA_reductase wikiPageWikiLinkText "3-hydroxy-3-methyl-glutaryl-CoA reductase".
- HMG-CoA_reductase wikiPageWikiLinkText "3-hydroxy-3-methyl-glutaryl-CoA".
- HMG-CoA_reductase wikiPageWikiLinkText "3-hydroxy-3-methylglutaryl-CoA reductase".
- HMG-CoA_reductase wikiPageWikiLinkText "Class II HMG-CoA reductases".
- HMG-CoA_reductase wikiPageWikiLinkText "HMG-CoA reductase (HMGR)".
- HMG-CoA_reductase wikiPageWikiLinkText "HMG-CoA reductase".
- HMG-CoA_reductase wikiPageWikiLinkText "HMG-CoA_reductase".
- HMG-CoA_reductase wikiPageWikiLinkText "hydroxymethylglutaryl CoA reductase".
- HMG-CoA_reductase wikiPageWikiLinkText "hydroxymethylglutaryl-CoA (HMG-CoA) reductase".
- HMG-CoA_reductase casNumber "37250".
- HMG-CoA_reductase ecNumber "1.1".
- HMG-CoA_reductase goCode "42282".
- HMG-CoA_reductase goCode "4420".
- HMG-CoA_reductase hasPhotoCollection HMG-CoA_reductase.
- HMG-CoA_reductase iubmbEcNumber "1".
- HMG-CoA_reductase name "hydroxymethylglutaryl-CoA reductase".
- HMG-CoA_reductase wikiPageUsesTemplate Template:Alcohol_oxidoreductases.
- HMG-CoA_reductase wikiPageUsesTemplate Template:Cite_journal.
- HMG-CoA_reductase wikiPageUsesTemplate Template:EC_number.
- HMG-CoA_reductase wikiPageUsesTemplate Template:Enzyme.
- HMG-CoA_reductase wikiPageUsesTemplate Template:Mevalonate_pathway.
- HMG-CoA_reductase wikiPageUsesTemplate Template:PBB.
- HMG-CoA_reductase wikiPageUsesTemplate Template:PDB_Gallery.
- HMG-CoA_reductase wikiPageUsesTemplate Template:Proteopedia.
- HMG-CoA_reductase wikiPageUsesTemplate Template:Refbegin.
- HMG-CoA_reductase wikiPageUsesTemplate Template:Refend.
- HMG-CoA_reductase wikiPageUsesTemplate Template:Reflist.
- HMG-CoA_reductase wikiPageUsesTemplate Template:StatinPathway_WP430.
- HMG-CoA_reductase subject Category:EC_1.1.1.
- HMG-CoA_reductase hypernym Enzyme.
- HMG-CoA_reductase type Biomolecule.
- HMG-CoA_reductase type Protein.
- HMG-CoA_reductase type Page.