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- HLA-DM abstract "HLA-DM (human leukocyte antigen DM) is an intracellular protein involved in peptide presentation by MHC class II. It is encoded by the genes HLA-DMA and HLA-DMB.In the endosomes, HLA-DM functions by promoting the dissociation of the CLIP peptide (a place holder peptide) from MHC class II which allows endosomal peptides to bind. Possibly by its preferential binding of the open, peptide-less conformation of MHC class II, HLA-DM then catalyzes peptide exchange, favoring more stable peptide-MHC complexes (which are resistant to DM action). Thus, HLA-DM is thought to play an important role in "editing" the peptide repertoire.HLA-DM is a protein involved in the immune system. It is a molecular chaperone that works in lysosomes and endosomes. HLA-DM plays a role in the proper loading of peptides and presentation of the peptides in macrophages, dendritic cells, B cells, and other antigen presenting cells. The protein is unable to bind peptides itself, so it interacts with major histocompatibility protein II (MHCII) to speed up the molecule’s binding and releasing of peptides. HLA-DM regulates the peptides that bind to MHCII and present the antigen on antigen presenting cells, therefore controlling which antigen(s) the body mounts an immune response to.The genes for HLA-DM are located in the MHCII region of the human chromosome 6. The genes code for the alpha and beta chains that makeup the protein. HLA-DM consists of two polymers and three ligands: BETA-D-MANNOSE (BMA), CHLORIDE ION (CL), and 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE (NDG). The structure of HLA-DM was determined by x-ray diffraction at a resolution of 2.27 Å.The Ramachandran Plot of HLA-DM can be seen here.".
- HLA-DM arm "p".
- HLA-DM band "21.3".
- HLA-DM chromosome "6".
- HLA-DM entrezgene "3108".
- HLA-DM entrezgene "3109".
- HLA-DM hgncid "4934".
- HLA-DM hgncid "4935".
- HLA-DM omim "142855".
- HLA-DM omim "142856".
- HLA-DM refseq "NM_002118".
- HLA-DM refseq "NM_006120".
- HLA-DM symbol "HLA-DMA".
- HLA-DM symbol "HLA-DMB".
- HLA-DM thumbnail 2BC4.pdb1.png?width=300.
- HLA-DM uniprot "P28067".
- HLA-DM uniprot "P28068".
- HLA-DM wikiPageExternalLink HLA-DM.html.
- HLA-DM wikiPageExternalLink explore.do?structureId=2BC4.
- HLA-DM wikiPageExternalLink 2BC4_ram_m_500.pdf.
- HLA-DM wikiPageID "11155831".
- HLA-DM wikiPageLength "4019".
- HLA-DM wikiPageOutDegree "12".
- HLA-DM wikiPageRevisionID "625291318".
- HLA-DM wikiPageWikiLink CLIP_(protein).
- HLA-DM wikiPageWikiLink Category:MHC_Class_II.
- HLA-DM wikiPageWikiLink Davidson_College.
- HLA-DM wikiPageWikiLink HLA-DMA.
- HLA-DM wikiPageWikiLink HLA-DMB.
- HLA-DM wikiPageWikiLink Intracellular.
- HLA-DM wikiPageWikiLink MHC_class_II.
- HLA-DM wikiPageWikiLink X-ray_crystallography.
- HLA-DM wikiPageWikiLinkText "DM".
- HLA-DM wikiPageWikiLinkText "HLA-DM".
- HLA-DM arm "p".
- HLA-DM band "21.3".
- HLA-DM caption "Crystallographic structure of human HLA-DM.".
- HLA-DM chromosome "6".
- HLA-DM entrezgene "3108".
- HLA-DM entrezgene "3109".
- HLA-DM hasPhotoCollection HLA-DM.
- HLA-DM hgncid "4934".
- HLA-DM hgncid "4935".
- HLA-DM name HLA-DMA.
- HLA-DM name HLA-DMB.
- HLA-DM omim "142855".
- HLA-DM omim "142856".
- HLA-DM refseq "NM_002118".
- HLA-DM refseq "NM_006120".
- HLA-DM symbol HLA-DMA.
- HLA-DM symbol HLA-DMB.
- HLA-DM uniprot "P28067".
- HLA-DM uniprot "P28068".
- HLA-DM wikiPageUsesTemplate Template:Doi.
- HLA-DM wikiPageUsesTemplate Template:Immunology-stub.
- HLA-DM wikiPageUsesTemplate Template:Protein.
- HLA-DM wikiPageUsesTemplate Template:Refimprove.
- HLA-DM wikiPageUsesTemplate Template:Reflist.
- HLA-DM wikiPageUsesTemplate Template:Surface_antigens.
- HLA-DM subject Category:MHC_Class_II.
- HLA-DM hypernym Protein.
- HLA-DM type Article.
- HLA-DM type Biomolecule.
- HLA-DM type Protein.
- HLA-DM type Article.
- HLA-DM type Chemical.
- HLA-DM type Glycoprotein.
- HLA-DM type Thing.
- HLA-DM type Q206229.
- HLA-DM type Q8054.
- HLA-DM comment "HLA-DM (human leukocyte antigen DM) is an intracellular protein involved in peptide presentation by MHC class II. It is encoded by the genes HLA-DMA and HLA-DMB.In the endosomes, HLA-DM functions by promoting the dissociation of the CLIP peptide (a place holder peptide) from MHC class II which allows endosomal peptides to bind.".
- HLA-DM label "HLA-DM".
- HLA-DM sameAs m.02r1xww.
- HLA-DM sameAs Q5630135.
- HLA-DM sameAs Q5630135.
- HLA-DM wasDerivedFrom HLA-DM?oldid=625291318.
- HLA-DM depiction 2BC4.pdb1.png.
- HLA-DM isPrimaryTopicOf HLA-DM.
- HLA-DM name "major histocompatibility complex, class II, DM alpha".
- HLA-DM name "major histocompatibility complex, class II, DM beta".