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- HCN_channel abstract "Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are intermembrane proteins that serve as nonselective ligand-gated cation channels in the plasma membranes of heart and brain cells. HCN channels are sometimes referred to as “pacemaker channels” because they help to generate rhythmic activity within groups of heart and brain cells. HCN channels are encoded by four genes (HCN1, 2, 3, 4) and are widely expressed throughout the heart and the central nervous system.The current through HCN channels, designated If or Ih, plays a key role in the control of cardiac and neuronal rhythmicity ("pacemaker current"). Expression of single isoforms in heterologous systems such as human embryonic kidney (HEK) cells, Chinese hamster ovary (CHO) cells, and Xenopus oocytes yields homotetrameric channels able to generate ion currents with properties similar to those of the native If/Ih current, but with quantitative differences in the voltage-dependence, activation/deactivation kinetics and sensitivity to the nucleotide cyclic AMP (cAMP): HCN1 channels show the more positive threshold for activation, the fastest activation kinetics, and the lowest sensitivity to cAMP, while HCN4 channels are slowly gating and strongly sensitive to cAMP. HCN2 and HCN3 have intermediate properties.".
- HCN_channel thumbnail PBB_Protein_HCN1_image.jpg?width=300.
- HCN_channel wikiPageID "14972851".
- HCN_channel wikiPageLength "10431".
- HCN_channel wikiPageOutDegree "44".
- HCN_channel wikiPageRevisionID "678197619".
- HCN_channel wikiPageWikiLink Alpha-2A_adrenergic_receptor.
- HCN_channel wikiPageWikiLink Brain.
- HCN_channel wikiPageWikiLink CHO_cell.
- HCN_channel wikiPageWikiLink Cardiac_rhythmicity.
- HCN_channel wikiPageWikiLink Category:Electrophysiology.
- HCN_channel wikiPageWikiLink Category:Integral_membrane_proteins.
- HCN_channel wikiPageWikiLink Category:Ion_channels.
- HCN_channel wikiPageWikiLink Category:Neurochemistry.
- HCN_channel wikiPageWikiLink Cation.
- HCN_channel wikiPageWikiLink Cell_membrane.
- HCN_channel wikiPageWikiLink Central_nervous_system.
- HCN_channel wikiPageWikiLink Chinese_hamster_ovary_cell.
- HCN_channel wikiPageWikiLink Cyclic_adenosine_monophosphate.
- HCN_channel wikiPageWikiLink Cyclic_nucleotide-gated_ion_channel.
- HCN_channel wikiPageWikiLink Dendritic_spine.
- HCN_channel wikiPageWikiLink File:PBB_Protein_HCN1_image.jpg.
- HCN_channel wikiPageWikiLink Functional_selectivity.
- HCN_channel wikiPageWikiLink Funny_current.
- HCN_channel wikiPageWikiLink Gene.
- HCN_channel wikiPageWikiLink Guanfacine.
- HCN_channel wikiPageWikiLink HCN1.
- HCN_channel wikiPageWikiLink HCN2.
- HCN_channel wikiPageWikiLink HCN3.
- HCN_channel wikiPageWikiLink HCN4.
- HCN_channel wikiPageWikiLink HEK_293_cells.
- HCN_channel wikiPageWikiLink HEK_cell.
- HCN_channel wikiPageWikiLink Habenula.
- HCN_channel wikiPageWikiLink Heart.
- HCN_channel wikiPageWikiLink Ion.
- HCN_channel wikiPageWikiLink Ion_channel.
- HCN_channel wikiPageWikiLink Isoform.
- HCN_channel wikiPageWikiLink Ligand-gated_ion_channel.
- HCN_channel wikiPageWikiLink Nicotine.
- HCN_channel wikiPageWikiLink Nonselective.
- HCN_channel wikiPageWikiLink Oocyte.
- HCN_channel wikiPageWikiLink Oocytes.
- HCN_channel wikiPageWikiLink Plasma_membrane.
- HCN_channel wikiPageWikiLink Potassium_channel.
- HCN_channel wikiPageWikiLink Protein.
- HCN_channel wikiPageWikiLink Protein_isoform.
- HCN_channel wikiPageWikiLink Proteins.
- HCN_channel wikiPageWikiLink Schizophrenia.
- HCN_channel wikiPageWikiLink Smoking_cessation.
- HCN_channel wikiPageWikiLink Working_memory.
- HCN_channel wikiPageWikiLink Xenopus.
- HCN_channel wikiPageWikiLinkText "HCN channel".
- HCN_channel wikiPageWikiLinkText "HCN channels".
- HCN_channel wikiPageWikiLinkText "HCN".
- HCN_channel wikiPageWikiLinkText "Hyperpolarization-activated cation channels".
- HCN_channel wikiPageWikiLinkText "cyclic nucleotide-gated ion channels".
- HCN_channel wikiPageWikiLinkText "hyperpolarization-activated cation current".
- HCN_channel hasPhotoCollection HCN_channel.
- HCN_channel wikiPageUsesTemplate Template:Cite_web.
- HCN_channel wikiPageUsesTemplate Template:Ion_channels.
- HCN_channel wikiPageUsesTemplate Template:Reflist.
- HCN_channel wikiPageUsesTemplate Template:SectOR.
- HCN_channel subject Category:Electrophysiology.
- HCN_channel subject Category:Integral_membrane_proteins.
- HCN_channel subject Category:Ion_channels.
- HCN_channel subject Category:Neurochemistry.
- HCN_channel hypernym Proteins.
- HCN_channel type Protein.
- HCN_channel type Biophysic.
- HCN_channel type Channel.
- HCN_channel comment "Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are intermembrane proteins that serve as nonselective ligand-gated cation channels in the plasma membranes of heart and brain cells. HCN channels are sometimes referred to as “pacemaker channels” because they help to generate rhythmic activity within groups of heart and brain cells.".
- HCN_channel label "HCN channel".
- HCN_channel sameAs HCN-Kanal.
- HCN_channel sameAs Protéine-canal_HCN.
- HCN_channel sameAs HCN_통로.
- HCN_channel sameAs m.0410_pw.
- HCN_channel sameAs HCN_канал.
- HCN_channel sameAs Q3459035.
- HCN_channel sameAs Q3459035.
- HCN_channel wasDerivedFrom HCN_channel?oldid=678197619.
- HCN_channel depiction PBB_Protein_HCN1_image.jpg.
- HCN_channel isPrimaryTopicOf HCN_channel.