Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/HBx> ?p ?o }
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- HBx abstract "HBx is a hepatitis B viral protein. It is 154 amino acids long and interferes with transcription, signal transduction, cell cycle progress, protein degradation, apoptosis and chromosomal stability in the host. It forms a heterodimeric complex with its cellular target protein (HBX interacting protein: HBXIP), and this interaction dysregulates centrosome dynamics and mitotic spindle formation. It interacts with DDB1 (Damaged DNA Binding Protein 1) redirecting the ubiquitin ligase activity of the CUL4-DDB1 E3 complexes, which are intimately involved in the intracellular regulation of DNA replication and repair, transcription and signal transduction.Although Protein X is normally absent in the Avihepadnavirus, a vestigial version has been identified in the duck hepatitis virus genome.Although it lacks significant sequence identity with any known vertebrate proteins, it seems likely that it evolved from a DNA glycosylase.Transgenic mice expressing the X protein in liver are more likely than the wild type to develop hepatocellular carcinoma. This is because the X protein promotes cell cycle progression while binding to and inhibiting tumor suppressor protein p53 from performing their role. Experimental observations also suggest that HBx protein increases TERT and telomerase activity, prolonging the lifespan of hepatocytes and contributing to malignant transformation.".
- HBx thumbnail HBV_genome.png?width=300.
- HBx wikiPageID "20938446".
- HBx wikiPageLength "6147".
- HBx wikiPageOutDegree "25".
- HBx wikiPageRevisionID "663269391".
- HBx wikiPageWikiLink Amino_acid.
- HBx wikiPageWikiLink Apoptosis.
- HBx wikiPageWikiLink Avihepadnavirus.
- HBx wikiPageWikiLink CUL4.
- HBx wikiPageWikiLink Category:Hepatitis_B_virus.
- HBx wikiPageWikiLink Category:Viral_proteins.
- HBx wikiPageWikiLink Cell_cycle.
- HBx wikiPageWikiLink Centrosome.
- HBx wikiPageWikiLink DNA.
- HBx wikiPageWikiLink DNA_glycosylase.
- HBx wikiPageWikiLink Damaged_DNA_Binding_Protein_1.
- HBx wikiPageWikiLink Gene_expression.
- HBx wikiPageWikiLink HBX_interacting_protein.
- HBx wikiPageWikiLink Hepatitis_B.
- HBx wikiPageWikiLink Methylation.
- HBx wikiPageWikiLink Methyltransferase.
- HBx wikiPageWikiLink Mitotic_spindle.
- HBx wikiPageWikiLink PRMT1.
- HBx wikiPageWikiLink Spindle_apparatus.
- HBx wikiPageWikiLink Telomerase.
- HBx wikiPageWikiLink Telomerase_reverse_transcriptase.
- HBx wikiPageWikiLink Transcription_(genetics).
- HBx wikiPageWikiLink Ubiquitin_ligase.
- HBx wikiPageWikiLink Viral_protein.
- HBx wikiPageWikiLink File:HBV_genome.png.
- HBx wikiPageWikiLinkText "HBx".
- HBx hasPhotoCollection HBx.
- HBx wikiPageUsesTemplate Template:Reflist.
- HBx wikiPageUsesTemplate Template:Viral_proteins.
- HBx wikiPageUsesTemplate Template:Virus-stub.
- HBx subject Category:Hepatitis_B_virus.
- HBx subject Category:Viral_proteins.
- HBx hypernym Protein.
- HBx type Protein.
- HBx comment "HBx is a hepatitis B viral protein. It is 154 amino acids long and interferes with transcription, signal transduction, cell cycle progress, protein degradation, apoptosis and chromosomal stability in the host. It forms a heterodimeric complex with its cellular target protein (HBX interacting protein: HBXIP), and this interaction dysregulates centrosome dynamics and mitotic spindle formation.".
- HBx label "HBx".
- HBx sameAs m.05b0dj2.
- HBx sameAs Q5629069.
- HBx sameAs Q5629069.
- HBx wasDerivedFrom HBx?oldid=663269391.
- HBx depiction HBV_genome.png.
- HBx isPrimaryTopicOf HBx.